Evidence for interactions between homocysteine and genistein: insights into stroke risk and potential treatment

Banecka-Majkutewicz, Zyta; Kadziński, Leszek; Grabowski, Michał; Bloch, Sylwia; Kaźmierkiewicz, Rajmund; Jakóbkiewicz‐Banecka, Joanna; Gabig-Cimińska, Magdalena; Węgrzyn, Grzegorz; Węgrzyn, Alicja; Banecki, Bogdan

doi:10.1007/s11011-017-0078-1

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…The supplementation with genistein (5, 7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) reduced plasma Hcy levels significantly. For this reason, genistein is considered as a potential substance for the prevention and treatment of CVDs and reduction of cardiovascular mortality [213]. Further, epigallocatechin-3-gallate (EGCG) prevents Hcy-induced apoptosis in endothelial cells by upregulation of SIRT1/AMPK and Akt/eNOS cell signaling.…”

Section: Nutritional Recommendations To Prevent Hhcy and Associated Pathologiesmentioning

confidence: 99%

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

et al. 2021

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Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic and epigenetic regulation mechanisms. Consequently, impaired Hcy metabolism leading to elevated concentrations of Hcy in the blood plasma (hyperhomocysteinemia) is linked to the overproduction of free radicals, induced oxidative stress, mitochondrial impairments, systemic inflammation and increased risks of eye disorders, coronary artery diseases, atherosclerosis, myocardial infarction, ischemic stroke, thrombotic events, cancer development and progression, osteoporosis, neurodegenerative disorders, pregnancy complications, delayed healing processes, and poor COVID-19 outcomes, among others. This review focuses on the homocysteine metabolism impairments relevant for various pathological conditions. Innovative strategies in the framework of 3P medicine consider Hcy metabolic pathways as the specific target for in vitro diagnostics, predictive medical approaches, cost-effective preventive measures, and optimized treatments tailored to the individualized patient profiles in primary, secondary, and tertiary care.

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Section: Nutritional Recommendations To Prevent Hhcy and Associated Pathologiesmentioning

confidence: 99%

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

et al. 2021

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“…Moderate hyperhomocysteinemia is associated with a 4-fold increase in the risk of ischemic diseases in children [ 19 ]. In adults, elevated HCys levels in the acute phase of ischemic stroke was suggested to be a risk factor for mortality [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Lipids and Selected Aminothiols in Epileptic Children—A Pilot Case-Control Study

2022

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Background: Standard treatment of epileptic seizures involves the use of antiepileptic drugs (AEDs). Both AEDs themselves and treatment duration may influence the levels of biochemical parameters, e.g., lipids or homocysteine (HCys), that may increase the risk of cardiovascular diseases. The aim of the present study was to compare the levels of lipid parameters, as well as the concentrations of selected aminothiols (i.e., HCys, cysteine, and glutathione) between epileptic children treated with multiple AEDs and children without epilepsy. Methods: In the study, 21 children with epilepsy treated with two or more AEDs for at least 6 months (8 girls and 13 boys, mean age 7.03 ± 4.51) and 23 children without epilepsy (7 girls and 16 boys, mean age 7.54 ± 3.90) were prospectively analyzed. Lipid parameters, i.e., total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL), and levels of selected aminothiols were determined in the blood serum. Results: No differences in the mean levels of lipid parameters and in the mean values of lipid ratios (TC/HDL, TG/HDL, LDL/HDL) were observed between the total groups as well as in the sex subgroups. HCys and cysteine levels did not differ between the patients and controls. We observed significantly lower levels of glutathione in children with epilepsy than in children without epilepsy (1.49 ± 0.35 µmol/L vs. 2.39 ± 1.17 µmol/L, respectively) (p < 0.001). Glutathione level was also lower in boys with epilepsy than in boys without epilepsy (p = 0.007). Similarly, epileptic girls had statistically decreased levels of glutathione when compared to girls without epilepsy (p = 0.006). Conclusions: A lower level of glutathione is observed in pediatric patients with epilepsy treated with two or more AEDs for at least 6 months. This indicates the oxidative stress of the patients treated with AEDs, which in turn may affect their well-being, and in the case of chronic occurrence resulting from long-term treatment, also on the function of the liver and the condition of the cardiovascular system.

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“…Banecka-Majkutewicz et al introduced genistein as a promising agent in treating stroke patients chiefly in case of dealing with hyperhomocysteinemia. 64 A systematic experiment by Yang et al yielded a remarkable neuroprotective effect of nanoformation (OEA-SPC NPs), which is a combination of N-oleoylethanolamin (OEA) and a carrier named soybean phosphatidylcholine (SPC). According to their study, the MCAO mice treated with that substance represented satisfying results as they showed decreased neurological dysfunction.…”

Section: Animal Studiesmentioning

confidence: 99%

Pharmacotherapeutic potential of soy isoflavones in neurological disorders

Mokhtari¹,

Qolipour²,

Yousefi³

et al. 2022

NeuroAsia

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In specific populations, soy products have been a part of their diet for many centuries. Soybeans are known to be beneficial mostly because of being rich sources of isoflavones. Various studies showed that Soy isoflavones such as daidzein and genistein have positive effects on gastrointestinal health, cancer prevention, and health promotion in postmenopausal women. In recent years, many studies focused on the neuroprotective effects of soy isoflavones in animal models and humans. This review includes the latest literature on the effects of soy isoflavones in various neurological disorders. In conclusion, soy isoflavones have neuroprotective, anti-inflammatory, and anti-oxidant effects and can be used to prevent stroke, improve memory and cognitive function, reduction of Parkinson’s disease symptoms, and also as a therapeutic agent in multiple sclerosis.

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Evidence for interactions between homocysteine and genistein: insights into stroke risk and potential treatment

Abstract: Elevated plasma homocysteine (2-amino-

Cited by 8 publications

References 28 publications

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

Serum Levels of Lipids and Selected Aminothiols in Epileptic Children—A Pilot Case-Control Study

Pharmacotherapeutic potential of soy isoflavones in neurological disorders

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