Evidence for increased motor cortical facilitation and decreased inhibition in atypical depression

Veronezi, Beatriz P.; Moffa, Adriano H.; Carvalho, André F.; Galhardoni, Ricardo; Simis, Marcel; Benseñor, Isabela M.; Lotufo, Paulo A.; Machado‐Vieira, Rodrigo; Daskalakis, Zafiris J.; Brunoni, André R.

doi:10.1111/acps.12565

Cited by 21 publications

(13 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The articles reviewed here provide neurophysiological evidence for altered cortical excitability (Maeda et al., 2000; Fitzgerald et al., 2004; Levinson et al., 2010; Spampinato et al., 2013; Concerto et al., 2013; Croarkin et al., 2013; Veronezi et al., 2016) and synaptic plasticity (Chroni et al., 2008; Bajwa et al., 2008; Spampinato et al., 2013; Croarkin et al., 2013; Player et al., 2013; Kuhn et al., 2016) in MDD. These data confirm the findings of previous investigations that have used different approaches (Debener et al., 2000; Normann et al., 2007; Teyler and Cavus, 2007; Salustri et al., 2007; Nissen et al., 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Studies that used rMT in depression (Abarbanel et al., 1996; Lefaucheur et al., 2008; Bajwa et al., 2008; Navarro et al., 2009) revealed that in these individuals, there is a global reduction in cortical excitability in the frontal cortex (Maeda et al., 2000; Fitzgerald et al., 2004; Levinson et al., 2010; Spampinato et al., 2013; Concerto et al., 2013; Croarkin et al., 2013; Veronezi et al., 2016), an interhemispheric imbalance between the prefrontal and motor cortices that manifested as reduced excitability in the left hemisphere (Maeda et al., 2000; Fitzgerald et al., 2004; Levinson et al., 2010; Spampinato et al., 2013; Concerto et al., 2013) or increased excitability in the right hemisphere (Bajbouj et al., 2006). In one study that investigated interhemispheric asymmetry in the prefrontal and motor cortices, 1 Hz (inhibitory) rTMS was applied to the left M1, and the results showed that the rTMS reduced cortical excitability in the ipsilateral side but did not induce any change (i.e., an increase in excitability) in the right hemisphere (Bajwa et al., 2008).…”

Section: Tms In Depressionmentioning

confidence: 99%

See 1 more Smart Citation

Cortical Plasticity in Depression

et al. 2017

View full text Add to dashboard Cite

Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression. Moreover, a degree of cognitive impairment is frequently observed throughout the clinical spectrum of mood disorders, and the relationship between depression and cognition is often bidirectional. However, most evidence for dysfunctional neural plasticity in depression has been indirect. Transcranial magnetic stimulation has emerged as a noninvasive tool for investigating several parameters of cortical excitability with the aim of exploring the functions of different neurotransmission pathways and for probing in vivo plasticity in both healthy humans and those with pathological conditions. In particular, depressed patients exhibit a significant interhemispheric difference in motor cortex excitability, an imbalanced inhibitory or excitatory intracortical neurochemical circuitry, reduced postexercise facilitation, and an impaired long-term potentiation-like response to paired-associative transcranial magnetic stimulation, and these symptoms may indicate disrupted plasticity. Research aimed at disentangling the mechanism by which neuroplasticity plays a role in the pathological processes that lead to depression and evaluating the effects of modulating neuroplasticity are needed for the field to facilitate more powerful translational research studies and identify novel therapeutic targets.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Tms In Depressionmentioning

confidence: 99%

Cortical Plasticity in Depression

et al. 2017

View full text Add to dashboard Cite

show abstract

“…For instance, in a study involving 60 patients with major depressive disorder and 21 controls, patients presented decreased cortical silent period values as a measure of cortical inhibition compared to controls. In addition, atypical depression presented a distinct cortical excitability pattern characterized by decreased cortical inhibition and increased cortical facilitation compared to other depression subtypes [281]. In fact, a meta-analysis investigating motor cortical excitability in psychiatric disorders showed that inhibitory deficits are a ubiquitous finding across major psychiatric disorders and enhancement of intracortical facilitation is specific to obsessive-compulsive disorder [282].…”

Section: Other Effects Of Motor Areas Modulationmentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

View full text Add to dashboard Cite

Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.

show abstract

“…Since LDAEP has been proposed as a biomarker of serotonin activity, the results suggest a relatively deficient serotonergic activity in patients with AD, which may be connected with their mood reactivity. 63 Recently, Veronezi et al, 64 using the transcranial magnetic stimulation method, found increased motor cortical facilitation and decreased inhibition in AD compared with other depression subtypes. This was related to gamma-aminobutyric acid A-receptor and glutamatergic activity in the motor cortex.…”

Section: Neurobiology and Neuropsychology Of Admentioning

confidence: 99%

Atypical depression: current perspectives

Łojko¹,

Rybakowski²

2017

NDT

View full text Add to dashboard Cite

The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with atypical feature is present for both diagnostic groups, that is, depressive disorders and bipolar and related disorders. This specifier includes mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity. Prevalence rates of AD are variable, depending on the criteria, methodology, and settings. The results of epidemiological studies using DSM criteria suggest that 15%–29% of depressed patients have AD, and the results of clinical studies point to a prevalence of 18%–36%. A relationship of AD with bipolar depression, seasonal depression, and obesity has also been postulated. Pathogenic research has been mostly focused on distinguishing AD from melancholic depression. The differences have been found in biochemical studies in the areas of hypothalamic–pituitary–adrenal axis, inflammatory markers, and the leptin system, although the results obtained are frequently controversial. A number of findings concerning such differences have also been obtained using neuroimaging and neurophysiological and neuropsychological methods. An initial concept of AD as a preferentially monoamine oxidase inhibitor-responsive depression, although confirmed in some further studies, is of limited use nowadays. Currently, despite numerous drug trials, there are no comprehensive treatment guidelines for AD. We finalize the article by describing the future research perspectives for the definition, neurobiology, and treatment. A better specification of diagnostic criteria and description of clinical picture, a genome-wide association study of AD, and establishing updated treatment recommendations for this clinical phenomenon should be the priorities for the coming years.

show abstract

Evidence for increased motor cortical facilitation and decreased inhibition in atypical depression

Abstract: Different MDD subtypes may demonstrate different neurophysiology in relation to GABAA and glutamatergic activity. TMS as an investigational tool might be useful to distinguish between different MDD subtypes.

Cited by 21 publications

References 48 publications

Cortical Plasticity in Depression

Cortical Plasticity in Depression

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Atypical depression: current perspectives

Contact Info

Product

Resources

About