Evidence for histamine-induced auto-anti-idiotypic antibody immunoregulation in vivo

Szewczuk, Myron R.; Campbell, Rita J.; Smith, James W.

doi:10.1016/0008-8749(81)90060-5

Cited by 9 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The discrep ancy between our results and those of Szewczuk et al [8] is probably due to a difference in the strain of mice used. We used C3H/HeN mice whereas Szewczuk et al [8] used FI (LAF1(C57L/J x A/HeJ)) mice. In ad dition, they indicated that histamine did not cause the induction of Ts.…”

Section: Discussioncontrasting

confidence: 99%

“…In ad dition, they indicated that histamine did not cause the induction of Ts. In the experiment for antibody pro duction with mice injected with T cells from donors injected with histamine 1 day before the cell transfer, our results were similar to those of Szewczuk et al [8]. Our results showed that the time interval between his tamine injection and cell transfer required 3 days for the induction of suppressor T cells, and that fraction ated T cells should be used as donor cells.…”

Section: Discussionsupporting

confidence: 89%

“…Szewczuk et al [8] reported that histamine injec tion prior to the stimulation of antigen induced the production of auto-anti-idiotipic antibodies in mice, and that these antibodies suppressed the secretion of the antigen-specific antibody from plasma cells. Our results indicated that antibody production decreased more in histamine-injected mice after immunization than in those which were injected with histamine prior to immunization.…”

Section: Discussionmentioning

confidence: 99%

“…Szewczuk et al [8] examined the suppressive effect of histamine on antibody production of antigen-im munized mice. They showed that anti-idiotypic anti bodies were produced by histamine in mice and pro posed that the suppression of antibody production is operating by the idiotype network system.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Suppressive Effect of Histamine on Anti-DNP Antibody Production in Mice

Okitsu‐Negishi

Furusawa²,

Yoshino³

et al. 1988

Int Arch Allergy Immunol

View full text Add to dashboard Cite

To clarify the effect of histamine on antibody production, histamine was injected intravenously into DNP-KLH immunized C3H/HeN female mice. The number of anti-DNP plaque-forming splenic cells decreased in immunized and histamine-injected mice. Decreased PFC responses similarly occurred in recipient mice into which Lyt-2.1 T cells obtained from histamine-injected mice were transferred before immunization. The effect of histamine is not due to inhibition on plaque formation. The results indicated that histamine induced the augmentation of suppressor T cell (Ts) function and caused the decrease of antibody production in histamine-injected mice. The maximum activity of Ts in recipient mice was obtained from mice injected with histamine 3 days before the cell transfer. The suppressive activity of histamine was not antigen specific because Ts was induced in histamine-injected, nonimmunized mice. The treatment of histamine type 2 (H2) agonist showed decreased PFC responses in the mouse as well as histamine did. When mice were treated with an H2 antagonist followed by histamine, antibody production was not reduced. The above results indicated that histamine seemed to regulate antibody production through H2 receptors on lymphocyte membranes.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Suppressive Effect of Histamine on Anti-DNP Antibody Production in Mice

Okitsu‐Negishi

Furusawa²,

Yoshino³

et al. 1988

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…In a number of experimental systems in vitro, the activity of lymphoid cells was shown to be affected by treatment with histamine or histamine H2-receptor agonists/antagonists. These systems include antigen-or mitogen-induced lymphtocyte proliferation (Strannegard & Strannegard, 1977;Wang & Zweiman, 1978;Brostoff etal., 1980;Hebert et al, 1980;Ogden & Hill, 1980;Suzuki & Huchet, 1981), lymphocyte-mediated cytotoxicity in different systems (Plaut et al, 1975;Schwartz et al, 1980;1981), production of migration inhibition factor (Rocklin, 1976), and antibody production (Lima & Rocklin, 1981;Szewczuk, et al, 1981). Strannegard & Strannegard (1977) also showed that lymphocytes from atopic individuals are more sensitive to inhibition of PHA-induced thymidine incorporation by histamine than cells from normal individuals.…”

Section: Introductionmentioning

confidence: 99%

Changes in bronchial anaphylactic reactivity induced in guinea‐pigs by long‐term treatment with histamine H₂‐agents

Andersson¹,

Bergstrand²

1984

British J Pharmacology

View full text Add to dashboard Cite

Guinea‐pigs were sensitized to ovalbumin (OA) by immunization regimens chosen to cause antigen‐induced bronchial anaphylactic responses mediated mainly either by IgE‐like antibodies or by IgG1‐like antibodies. Treatment of the IgE‐producing animals for three weeks with the histamine H2‐receptor antagonist cimetidine (1 mg kg−1 i.p. once a day) or with the H2‐agonist dimaprit (0.1, 1.0, or 10 mg kg−1 i.p. once a day) led to a significantly reduced bronchial response capacity compared with that of the saline‐treated controls challenged intravenously with antigen one week after the end of treatment. The changes were biphasic and not strictly dose‐dependent. In contrast, acute treatment of immunized animals with a single dose of cimetidine (10 or 30 mg kg−1 i.v.) or dimaprit (1 or 10 mg kg−1 i.v.) 2 min before challenge with OA did not significantly affect the bronchial anaphylactic response. However, long‐term treatment with cimetidine (10 mg kg−1) or the dimaprit analogue, S‐[4‐(N, N‐dimethylamino)‐butyl] isothiourea (SKF Compound 91488) (1 mg kg−1), which is reported not to activate H2‐receptors, had no effect on the response capacity. Treatment with cimetidine (1 mg kg−1) or dimaprit (1 mg kg−1) did not influence the response capacity to antigen challenge in IgG1‐ type animals. Dimaprit (1 mg kg−1) did not affect the responsiveness to intravenous provocation with histamine in ‘IgE‐type’ animals. Antigen‐induced release of histamine from chopped lung tissue in vitro was not significantly affected in ‘IgE‐type’ animals treated with cimetidine (1 mg kg−1) or dimaprit (1 mg kg−1). Treatment of immunized animals with cimetidine or dimaprit one week before and one week after a booster injection of antigen also led to reduced response capacity compared with that of saline‐treated controls. However, the serum levels of IgE‐like homocytotropic antibodies of these animals were not reduced; on the contrary, those of IgG1‐antibody were increased in dimaprit‐treated animals. These data show that intermittent treatment with histamine H2‐agents reduces reagin‐mediated anaphylactic response capacity in vivo in actively sensitized guinea‐pigs by an as yet undefined mode of action.

show abstract

Histamine-induced inhibition of lymphocyte proliferation and lysosomal enzyme release from polymorphs may not be mediated via H1- or H2-receptors

Vickers¹,

Milliner²,

Martin³

et al. 1982

Agents and Actions

View full text Add to dashboard Cite

Histamine, selective histamine H1- and H2-receptor agonists, and chemical analogues of these compounds lacking activity at histamine receptors, were tested as inhibitors of phytohaemagglutinin-induced human lymphocyte proliferation and zymosan-induced release of lysosomal enzymes from human polymorphs. No correlation was found between their inhibitory potency in these systems and their relative activity at histamine H1- or H2-receptors.

show abstract

Evidence for histamine-induced auto-anti-idiotypic antibody immunoregulation in vivo

Cited by 9 publications

References 23 publications

The Suppressive Effect of Histamine on Anti-DNP Antibody Production in Mice

The Suppressive Effect of Histamine on Anti-DNP Antibody Production in Mice

Changes in bronchial anaphylactic reactivity induced in guinea‐pigs by long‐term treatment with histamine H₂‐agents

Histamine-induced inhibition of lymphocyte proliferation and lysosomal enzyme release from polymorphs may not be mediated via H1- or H2-receptors

Contact Info

Product

Resources

About

Evidence for histamine-induced auto-anti-idiotypic antibody immunoregulation in vivo

Cited by 9 publications

References 23 publications

The Suppressive Effect of Histamine on Anti-DNP Antibody Production in Mice

The Suppressive Effect of Histamine on Anti-DNP Antibody Production in Mice

Changes in bronchial anaphylactic reactivity induced in guinea‐pigs by long‐term treatment with histamine H2‐agents

Histamine-induced inhibition of lymphocyte proliferation and lysosomal enzyme release from polymorphs may not be mediated via H1- or H2-receptors

Contact Info

Product

Resources

About

Changes in bronchial anaphylactic reactivity induced in guinea‐pigs by long‐term treatment with histamine H₂‐agents