Evidence for highly specific interactions between Δ8- and Δ9-tetrahydrocannabinol and hydrocortisone in the rodent tyrosine aminotransferase system

Wrenn, Jacqueline M.; Friedman, Marvin A.

doi:10.1016/s0041-008x(78)80016-7

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Several studies have shown that both biochemical and behavioral effects of A9-THC are altered by administration of CS [33] or by a variety of stressful conditions [7. 23].…”

Section: Discussionmentioning

confidence: 99%

Adrenalectomy Reverses the Effects of Delta-9-THC on Mouse Brain 5-Hydroxytryptamine Turnover

Johnson¹,

Dewey²,

Bloom³

1981

Pharmacology

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Acute administration of certain cannabinoids, including Δ⁹-tetrahydrocannabinol (Δ⁹-THC), resulted in elevated levels of plasma corticosterone in mice. The rank order potency of these cannabinoids is the same as others have reported using behavioral tests. The maximally effective dose of Δ⁹-THC (30 mg/kg) in this test also increased the amount of ³H-tryptophan found in the brains of mice given an intravenous injection of ³H-tryptophan 10 min prior to decapitation. This effect was associated with an increase in the amount of ³H-5-hydroxytryptamine synthesized during the pulse period. Adrenalectomy was found to inhibit these effects of Δ⁹-THC. The possibility that corticosterone may mediate the effects of Δ⁹-THC on tryptophan disposition and metabolism is discussed.

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“…Several studies have shown that both biochemical and behavioral effects of A9-THC are altered by administration of CS [33] or by a variety of stressful conditions [7. 23].…”

Section: Discussionmentioning

confidence: 99%

Adrenalectomy Reverses the Effects of Delta-9-THC on Mouse Brain 5-Hydroxytryptamine Turnover

Johnson¹,

Dewey²,

Bloom³

1981

Pharmacology

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“…In an early assessment of tolerance to Δ 8 -THC, after chronic administration and mice sacrifice, the livers demonstrated significant increases in tyrosine aminotransferase activity with acute administration; however, little-to-no increased activity was noted after 8 and 12 weeks of chronic administration of Δ 8 -THC [ 169 ]. Additionally, the Birmingham School of Medicine has reported recently a notable surge in the frequency of emergency department admissions, both in their own hospital and in several others, attributed to the utilization of Δ 8 -THC [ 170 ].…”

Section: Pharmacology Of δ 8 -Thcmentioning

confidence: 99%

Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol

Abdel-Kader,

Radwan,

Metwaly

et al. 2024

Molecules

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Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has moved and flourished in the Western nations in more recent centuries. C. sativa is the source of psychoactive cannabinoids that are consumed as recreational drugs worldwide. The C21 aromatic hydrocarbons are restricted in their natural occurrence to cannabis (with a few exceptions). Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive component in cannabis, with many pharmacological effects and various approved medical applications. However, a wide range of side effects are associated with the use of Δ9-THC, limiting its medical use. In 1966, another psychoactive cannabinoid, Delta-8-tetrahydrocannabinol (Δ8-THC) was isolated from marijuana grown in Maryland but in very low yield. Δ8-THC is gaining increased popularity due to its better stability and easier synthetic manufacturing procedures compared to Δ9-THC. The passing of the U.S. Farm Bill in 2018 led to an increase in the sale of Δ8-THC in the United States. The marketed products contain Δ8-THC from synthetic sources. In this review, methods of extraction, purification, and structure elucidation of Δ8-THC will be presented. The issue of whether Δ8-THC is a natural compound or an artifact will be discussed, and the different strategies for its chemical synthesis will be presented. Δ8-THC of synthetic origin is expected to contain some impurities due to residual amounts of starting materials and reagents, as well as side products of the reactions. The various methods of analysis and detection of impurities present in the marketed products will be discussed. The pharmacological effects of Δ8-THC, including its interaction with CB1 and CB2 cannabinoid receptors in comparison with Δ9-THC, will be reviewed.

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“…In an early assessment of tolerance to ∆ 8 -THC, after chronic administration and mice sacrifice, the livers demonstrated significant increases in tyrosine aminotransferase activity with acute administration; however, little-to-no increased activity was noted after 8 and 12 weeks of chronic administration of ∆ 8 -THC [169]. Additionally, the Birmingham School of Medicine has reported recently a notable surge in the frequency of emergency department admissions, both in their own hospital and in several others, attributed to the utilization of ∆ 8 -THC [170].…”

Section: Toxicity Of ∆ 8 -Thcmentioning

confidence: 99%

Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol

Abdel-Kader,

Radwan,

Metwaly

et al. 2024

Preprint

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Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern part of the hemisphere, its use has moved and flourished in the Western Nations in more recent centuries. C. sativa is the source of psychoactive cannabinoids that are consumed as recreational drugs worldwide. The C21 aromatic hydrocarbons are restricted in their natural occurrence to cannabis (with a few exceptions). Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive component in cannabis with many pharmacological effects and various approved medical applications. However, a wide range of side effects are associated with the use of Δ9-THC, limiting its medical use. In 1966, another psychoactive cannabinoid, Delta-8-tetrahydrocannabinol (Δ8-THC) was isolated from marijuana grown in Maryland but in very low yield. Δ8-THC is gaining increased popularity due to its better stability and easier synthetic manufacturing procedures compared to Δ9-THC. Passing the U.S. Farm Bill in 2018 led to an increase in the sale of Δ8-THC in the United States. The marketed products contain Δ8-THC from synthetic sources. In this review, methods of extraction, purification, and structure elucidation of Δ8-THC will be presented. The issue of whether Δ8-THC is a natural compound or an artifact will be discussed, and the different strategies for its chemical synthesis will be presented. Δ8-THC of synthetic origin is expected to contain some impurities due to residual amounts of starting materials and reagents as well as side products of the reactions. The various methods of analysis and detection of impurities present in the marketed products will be discussed. The pharmacological effects of Δ8-THC, including its interaction with CB1 and CB2 cannabinoid receptors in comparison with Δ9-THC, will be reviewed.

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Evidence for highly specific interactions between Δ8- and Δ9-tetrahydrocannabinol and hydrocortisone in the rodent tyrosine aminotransferase system

Cited by 6 publications

References 8 publications

Adrenalectomy Reverses the Effects of Delta-9-THC on Mouse Brain 5-Hydroxytryptamine Turnover

Adrenalectomy Reverses the Effects of Delta-9-THC on Mouse Brain 5-Hydroxytryptamine Turnover

Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol

Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol

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