Evidence for hepato-biliary transport of immunoglobulin in the antarctic teleost fish Trematomus bernacchii

Cytogenetic mapping of immunoglobulin heavy chain genes in Antarctic fish

“…In T. bernacchii, IgM molecules have been extensively studied (Pucci et al 2003;Abelli et al 2005 among others) and both VH and CH genes have been investigated (Coscia et al 2000;Oreste and Coscia 2002;Coscia and Oreste 2003).…”

Immunoglobulin protein and gene transcripts in sea bream (Sparus aurata L.) oocytes

“…2B, C) suggesting an active role of the latter in the uptake of Ig. In addition, these data indicated the occurrence of a transcellular transport of Ig across follicle cells, as described in polarized epithelial cells of mammals [11] and birds [12] but only hypothesised in fish so far [7,13]. Otherwise, the transport to the egg of vitellogenic proteins [14] and exogenous components of the egg envelope [15] did not involve follicle cells.…”

The trenbolone acetate affects the immune system in rainbow trout, Oncorhynchus mykiss

“…Third, both endogenous androgens, testosterone and 11-ketotestosterone (11-KT), modify in vivo and in vitro the: (v) phagocytosis in carp (Watanuki et al, 2002;Yamaguchi and Watanuki, 2001). Finally, it has also been proved that testosterone and 11-KT decrease the: (vi) immunoglobulin concentration in plasma (Hou et al, 1999a) and reduce the transport of this molecule by the polymeric immunoglobulin receptor (pIgR) in mammals (Abelli et al, 2005). In order to verify whether the trenbolone acetate has the same effects on the immune system of rainbow trout, we evaluated the TbA effects on the proportion of: (i) leucocyte populations and on the expression of some genes involved in the development of lymphocytes and granulocytes (RAG-1, RAG-2 and SPI-1) and in the renal cellular proliferation (IL-1B and TGF-B1).…”

“…The immunoglobulins (Ig) are produced by the hepatic plasma B cells, transported across the hepatocytes and released into the bile (Abelli et al, 2005). In vertebrates, this transport is mediated by the polymeric Ig receptor (pIgR).…”