Evidence for growth-promoting effects of Omega n −3 fatty acids alone and in combination with a specific vitamin and mineral complex in rat neuroblastoma cells

Shrivastava, Ravi; Vincent, Bernard; Gobron, Stéphane; Cucuat, Nathalie; John, Gareth W.

doi:10.1080/10284150500510242

Cited by 6 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment of PC12 cells for 3 days with n-3 PUFA significantly enhances neurite length without affecting the number of neurites (Shrivastava et al , 2005). DHA also induces neurite outgrowth in cells beginning as early as 2 h post-DHA supplementation and throughout differentiation.…”

Section: Effects Of Dha On Synapsesmentioning

confidence: 89%

Effects of Docosahexaenoic Acid on Neurotransmission

Tanaka

Farooqui²,

Siddiqi³

et al. 2012

Biomolecules and Therapeutics

View full text Add to dashboard Cite

Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain and a structural component of neuronal membranes. Changes in DHA content of neuronal membranes lead to functional changes in the activity of receptors and other proteins which might be associated with synaptic function. Accumulating evidence suggests the beneficial effects of dietary DHA supplementation on neurotransmission. This article reviews the beneficial effects of DHA on the brain; uptake, incorporation and release of DHA at synapses, effects of DHA on synapses, effects of DHA on neurotransmitters, DHA metabolites, and changes in DHA with age. Further studies to better understand the metabolome of DHA could result in more effective use of this molecule for treatment of neurodegenerative or neuropsychiatric diseases.

show abstract

Section: Effects Of Dha On Synapsesmentioning

confidence: 89%

Effects of Docosahexaenoic Acid on Neurotransmission

Tanaka

Farooqui²,

Siddiqi³

et al. 2012

Biomolecules and Therapeutics

View full text Add to dashboard Cite

show abstract

“…DHA supplementation increased neurite outgrowth and neurite branching in embryonic hippocampal cultures from rats [118] and mice [119], and in neuronal cultures derived from mouse embryonic stem cells [120]. A combination of omega-3 PUFAs and multiple vitamins and minerals was more effective in promoting neurite outgrowth in neuroblastoma cells (measured as average neurite length and the number of neurites per cell) compared with either omega-3 PUFAs or vitamins plus minerals alone [121]. Enrichment of cell culture medium with a combination of vitamins B 1 , B 6 , and B 12 increased neurite outgrowth from dorsal root ganglia [122].…”

Section: Stimulating Synapse Formationmentioning

confidence: 98%

Targeting Synaptic Dysfunction in Alzheimer's Disease by Administering a Specific Nutrient Combination

Wijk

Broersen

Wilde

et al. 2013

JAD

107

101

View full text Add to dashboard Cite

Synapse loss and synaptic dysfunction are pathological processes already involved in the early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal membranes, and the neuronal and synaptic losses observed in AD have been linked to the degeneration and altered composition and structure of these membranes. Consequently, synapse loss and membrane-related pathology provide viable targets for intervention in AD. The specific nutrient combination Fortasyn Connect (FC) is designed to ameliorate synapse loss and synaptic dysfunction in AD by addressing distinct nutritional needs believed to be present in these patients. This nutrient combination comprises uridine, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium, and is present in Souvenaid, a medical food intended for use in early AD. It has been hypothesized that FC counteracts synaptic loss and reduces membrane-related pathology in AD by providing nutritional precursors and cofactors that act together to support neuronal membrane formation and function. Preclinical studies formed the basis of this hypothesis which is being validated in a broad clinical study program investigating the potential of this nutrient combination in AD. Memory dysfunction is one key early manifestation in AD and is associated with synapse loss. The clinical studies to date show that the FC-containing medical food improves memory function and preserves functional brain network organization in mild AD compared with controls, supporting the hypothesis that this intervention counteracts synaptic dysfunction. This review provides a comprehensive overview of basic scientific studies that led to the creation of FC and of its effects in various preclinical models.

show abstract

“…Antioxidants reduce ROS-induced damage and stabilize membranes, suppressing synaptic loss. In vitro studies with PUFAs combined with a vitamin and mineral complex, or supplementation with a vitamin-B complex (B 1 , B 6 , and B 12 ) have been shown to increase neurite formation [46,47]. Administration of multiple nutrients (including DHA, choline, uridine, and Bvitamins) promotes receptor-mediated (e.g., P 2 Y and syntaxin) synthesis of synaptic membranes and neurite outgrowth [48].…”

Section: Synaptic Lossmentioning

confidence: 99%

Can Nutrients Prevent or Delay Onset of Alzheimer's Disease?

Kamphuis

Scheltens

2010

JAD

View full text Add to dashboard Cite

Age-related changes in nutritional status can play an important role in brain functioning. Specific nutrient deficiencies in the elderly, including omega-3 fatty acids, B-vitamins, and antioxidants among others, may exacerbate pathological processes in the brain. Consequently, the potential of nutritional intervention to prevent or delay cognitive impairment and the development of Alzheimer's disease (AD) is a topic of growing scientific interest. This review summarizes epidemiological studies linking specific nutritional deficiencies to mild cognitive impairment (MCI), as well as completed and ongoing nutritional studies in prevention of MCI and AD. Processes that underlie AD pathogenesis include: membrane/synaptic degeneration, abnormal protein processing (amyloid-beta, tau), vascular risk factors (hypertension, hypercholesterolemia), inflammation, and oxidative stress. Consideration of mechanistic evidence to date suggests that several nutritional components can effectively counteract these processes, e.g., by promoting membrane formation and synaptogenesis, enhancing memory/behavior, improving endothelial function, and cerebrovascular health. The literature reinforces the need for early intervention in AD and suggests that multi-nutritional intervention, targeting multiple aspects of the neurodegenerative process during the earliest possible phase in the development of the disease, is likely to have the greatest therapeutic potential.

show abstract

Evidence for growth-promoting effects of Omega n −3 fatty acids alone and in combination with a specific vitamin and mineral complex in rat neuroblastoma cells

Cited by 6 publications

References 26 publications

Effects of Docosahexaenoic Acid on Neurotransmission

Effects of Docosahexaenoic Acid on Neurotransmission

Targeting Synaptic Dysfunction in Alzheimer's Disease by Administering a Specific Nutrient Combination

Can Nutrients Prevent or Delay Onset of Alzheimer's Disease?

Contact Info

Product

Resources

About