“…Whereas full-length VAR2CSA recombinant proteins are highly immunogenic, the adhesion blocking activity they elicited was strain specific (19,27). Conversely, most single-domain antigens, with the exception of DBL4ε and DBL5ε, have elicited limited adhesion blocking activity (28,29,30,31,32). More recently, larger, multidomain VAR2CSA constructs incorporating the "core" binding region (DBL2 plus flanking regions) was shown to elicit adhesion blocking antibodies that were partially cross-inhibitory on placental isolates (23,33).…”