Evidence for genistein mediated cytotoxicity and apoptosis in rat brain

Choi, Eun Jeong; Lee, Byung Ho

doi:10.1016/j.lfs.2004.01.010

Cited by 59 publications

(31 citation statements)

References 35 publications

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“…Many have reported that isoflavones significantly inhibit breast cancer cell growth in vitro (6)(7)(8), and that this growth inhibition stimulates the signal transduction pathway leading to apoptosis. Moreover, our previous studies support the theory that isoflavones, including genistein and daidzein, exhibit anticancer activity against breast cancer both in vivo (9,10) and in vitro (11,12).…”

Section: Introductionsupporting

confidence: 81%

Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells

Choi

Kim

2013

Molecular Medicine Reports

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Abstract. In this study, we investigated the antiproliferative activity of the isoflavones daidzein and genistein in three breast cancer cell lines with different patterns of estrogen receptor (ER) and c-erbB-2 protein expression (ERα-positive MCF-7 cells, c-erbB-2-positive SK-BR-3 cells and ERα/c-erbB-2-positive ZR-75-1). After treatment at various concentrations (1-200 µM for 72 h), the effect of daidzein and genistein on the proliferation of different cell types varied; these effects were found to be associated with ERα and c-erbB-2 expression. Daidzein and genistein exhibited biphasic effects (stimulatory or inhibitory) on proliferation and ERα expression in MCF-7 cells. Although 1 µM daidzein significantly stimulated cell growth, ERα expression was unaffected. However, genistein showed marked increases in proliferation and ERα expression after exposure to <10 µM genistein. Notably, the inhibition of cell proliferation by 200 µM genistein was greater compared to that by daidzein at the same concentration. Daidzein and genistein significantly inhibited proliferation of SK-BR-3 and ZR-75-1 cells in a dose-dependent manner. In addition, ERα and c-erbB-2 expression was reduced by daidzein and genistein in both SK-BR-3 and ZR-75-1 cells in a dose-dependent manner. However, the effect of genistein was greater compared to that of daidzein. In conclusion, the isoflavones daidzein and genistein showed anti-breast cancer activity, which was associated with expression of the ERα and c-erbB-2 receptors.

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Section: Introductionsupporting

confidence: 81%

Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells

Choi

Kim

2013

Molecular Medicine Reports

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“…139,140 However, genistein has also been shown to induce apoptosis through additional factors such as caspase-3 activation (an end-effector of apoptosis) and reduction in mitochondrial membrane potential. [141][142][143] These latter actions of genistein would be detrimental to cardiac health. Given these conflicting properties of soy isoflavones, it is difficult to predict which bioactive activity of isoflavones will predominate in the context of CVD in both humans and laboratory rodents.…”

Section: Phytoestrogensmentioning

confidence: 99%

The Effects of Biological Sex and Diet on the Development of Heart Failure

Konhilas

Leinwand

2007

Circulation

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“…It is generally synthesized in cells as an inactive zymogene (32 kDa) and requires proteolytic activation. After the activation, it is cleaved at the carboxyl sides of two specific aspartic acid residues to form two mature subunits, p18 (18 kDa) and p12 (12 kDa) [19]. Caspase-3 activation is essential for certain processes associated with the dismantling of the cell and the formation of apoptotic bodies [20].…”

Section: Daidzeinmentioning

confidence: 99%

The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

et al. 2007

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Abstract:The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.

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Evidence for genistein mediated cytotoxicity and apoptosis in rat brain

Cited by 59 publications

References 35 publications

Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells

Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells

The Effects of Biological Sex and Diet on the Development of Heart Failure

The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

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