Evidence for functional estrogen receptors α and β in human adipose cells: regional specificities and regulation by estrogens

Dieudonné, Marie‐Noëlle; Leneveu, Marie-Christine; Giudicelli, Yves; Pecquery, René

doi:10.1152/ajpcell.00321.2003

Cited by 168 publications

(156 citation statements)

References 51 publications

(48 reference statements)

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…7 ER mRNAs are expressed in mature human adipocytes where the ERa mRNA predominates. 8 ERa mRNA levels do not differ in adipocytes from different anatomical origins (intraabdominal or subcutaneous) or according to gender in non-obese individuals. 8 Women usually increase their body weight after menopause when oestrogen levels naturally decrease.…”

Section: Introductionmentioning

confidence: 85%

Oestrogen receptor α gene expression levels are reduced in obese compared to normal weight females

et al. 2007

View full text Add to dashboard Cite

Objective: To determine whether oestrogen receptor (ER)a messenger RNA (mRNA) levels or single nucleotide polymorphisms (SNPs) are associated with obesity in Swedish women. Design: ERa mRNA expression levels were measured by real-time qPCR in subcutaneous adipose tissue from non-obese (N ¼ 16, BMI o30) and obese (N ¼ 17, BMI X30) women. In addition, ERa mRNA expression levels were determined in isolated adipocytes. ERa promoter usage was characterized by 5 0 RACE and by real-time qPCR in subcutaneous adipose tissue from the same non-obese and obese women. Two ERa SNPs were scored in 509 non-obese and 489 obese females. Results: ERa mRNA expression levels were lower in obese compared to non-obese women in both subcutaneous adipose tissue and in adipocytes. We show that two ERa promoters are differentially utilized in obese and non-obese individuals. We did not find any significant association between obesity and the ERa SNPs or haplotypes assayed. Conclusion: The reduced ERa mRNA levels observed in adipose tissue from obese compared to non-obese women support a role for oestrogen signaling via ERa, in control of body weight. Mechanistic studies of the role of ERa in adipocytes and how its expression is regulated in relation to fat mass should be performed. The latter studies should focus on the two promoters that are used differently in obese and non-obese individuals.

show abstract

Section: Introductionmentioning

confidence: 85%

Oestrogen receptor α gene expression levels are reduced in obese compared to normal weight females

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Potential gene targets of E2 can be estimated by the expression and distribution of its receptors. Studies investigating the expression patterns of ER-a and ER-b showed that they are expressed in rat and human preadipocytes, mature adipocytes, and other cell types present in adipose tissue, including macrophages (Price and O'Brien 1993;Crandall et al 1998;Dieudonne et al 2004). Various studies have shown that E2 regulates adipocyte differentiation; however, the results are contradictory.…”

Section: Steroid Hormonesmentioning

confidence: 99%

Adipogenesis

Sarjeant

Stephens

2012

Cold Spring Harbor Perspectives in Biology

264

236

View full text Add to dashboard Cite

SUMMARYAdipose tissue is an important site for lipid storage, energy homeostasis, and whole-body insulin sensitivity. It is important to understand the mechanisms involved in adipose tissue development and function, which can be regulated by the endocrine actions of various peptide and steroid hormones. Recent studies have revealed that white and brown adipocytes can be derived from distinct precursor cells. This review will focus on transcriptional control of adipogenesis and its regulation by several endocrine hormones. The general functions and cellular origins of adipose tissue and how the modulation of adipocyte development pertains to metabolic disease states will also be considered.

show abstract

“…Several lines of recent evidence suggest a potential role for ER-α in the determination of BMI. ER-α may play a critical role in adipose tissue development, metabolism, deposi tion [10,11] and energy metabolism [12] . The estrogen antagonist acting on ER-α can prevent diet-and ovariectomy-induced obesity, mainly by decreasing fat deposition [13] .…”

Section: Introductionmentioning

confidence: 99%

Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women

Xiao

Luo

et al. 2010

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: To investigate whether estrogen receptor α (ER-α) PvuII and osteocalcin (also known as bone Gla protein, or BGP) HindIII genetic polymorphisms and their potential interactions are associated with body mass index (BMI) variation. Methods: Data on BMI and ER-α PvuII and BGP HindIII genotypes were obtained from 328 healthy premenopausal Chinese women in east China. The study subjects were unrelated, at least 21 years old (mean age of 33.2±5.9 years), and had an average BMI of 21.58±2.59. All subjects were genotyped at the ER-α PvuII and BGP HindIII loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: The BGP HindIII genotypes were significantly associated with BMI (P=0.003). Carriers of the HH and Hh genotypes had approximately 2.73% and 1.27% higher BMI than those of the hh genotype, respectively. In contrast, the ER-α PvuII polymorphism was not significantly associated with BMI (P=0.454). In addition, there was no evidence of potential interactions between the ER-α and BGP genes in our subjects (P≥0.013). Conclusion:The HindIII polymorphism of the BGP gene, but not the PvuII polymorphism of the ER-α gene or their potential interaction, was associated with BMI in premenopausal Chinese women.

show abstract

Evidence for functional estrogen receptors α and β in human adipose cells: regional specificities and regulation by estrogens

Cited by 168 publications

References 51 publications

Oestrogen receptor α gene expression levels are reduced in obese compared to normal weight females

Oestrogen receptor α gene expression levels are reduced in obese compared to normal weight females

Adipogenesis

Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women

Contact Info

Product

Resources

About