Evidence for frequent focal and diffuse acute axonal injury in human bacterial meningitis

Gerber, Joachim; Rc, Seitz; Bunkowski, Stephanie; Brück, Wolfgang; Nau, R.

doi:10.5414/npp28033

Cited by 22 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surprisingly, axonal damage in the present series of HIV‐infected cases did not appear to play a prominent role in the pathophysiological process: it was much milder than the injury found in acute or subacute CNS infections such as bacterial meningitis, fungal meningoencephalitis and septic encephalitis [17,22,34,35]. Although demyelinating leukoencephalopathy is a typical feature of HIV encephalopathy [36], axonal injury in the present HIV‐infected cases was not more severe than in control cases.…”

Section: Discussioncontrasting

confidence: 56%

“…As in bacterial meningitis [34], septic encephalitis [17] and fungal meningoencephalitis [22], the brains of autopsy cases with HIV encephalopathy showed an increased proliferation rate of progenitor cells in the hippocampal dentate granule cell layer and subgranular zone. As in fungal meningoencephalitis, but unlike in bacterial meningitis and septic‐metastatic encephalitis, the differentiation of young progenitor cells into neurons was not significantly increased.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

HIV encephalopathy: glial activation and hippocampal neuronal apoptosis, but limited neural repair

Tauber

Staszewski²,

Prinz³

et al. 2015

HIV Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

HIV encephalopathy: glial activation and hippocampal neuronal apoptosis, but limited neural repair

Tauber

Staszewski²,

Prinz³

et al. 2015

HIV Medicine

View full text Add to dashboard Cite

show abstract

“…Three control cases of this study without brain pathology at routine autopsy also displayed mild axonal injury. Minor axonal affection was also observed in four human autopsy cases of the control group in a study investigating neuropathological alterations after bacterial meningitis [17]. One can speculate whether this is a phenomenon of age as old age seems to increase the susceptibility to neuronal damage in general [22].…”

Section: Discussionmentioning

confidence: 77%

Septic metastatic encephalitis: coexistence of brain damage and repair

Tauber

Bunkowski

Brück

et al. 2011

Neuropathology Appl Neurobio

Self Cite

View full text Add to dashboard Cite

show abstract

“…Neuronal cell damage is evident in the hippocampal formation, the neocortex, the basal ganglia, and the brain stem of victims of bacterial meningitis [3,4]. Additionally, axonal injury in the white matter has been reported in animal meningitis models and in human bacterial meningitis [5,6]. …”

Section: Introductionmentioning

confidence: 99%

Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis

Liebetanz

Gerber²,

Schiffner

et al. 2012

J Neuroinflammation

View full text Add to dashboard Cite

Physical exercise has been shown to increase neurogenesis, to decrease neuronal injury and to improve memory in animal models of stroke and head trauma. Therefore, we investigated the effect of voluntary wheel running on survival, neuronal damage and cell proliferation in a mouse model of pneumococcal meningitis. Mice were housed in cages equipped with voluntary running wheels or in standard cages before induction of bacterial meningitis by a subarachnoid injection of a Streptococcus pneumoniae type 3 strain. 24 hours later antibiotic treatment was initiated with ceftriaxone (100 mg/kg twice daily). Experiments were terminated either 30 hours or 4 days (short-term) or 7 weeks (long-term) after infection, and the survival time, inflammatory cytokines and corticosterone levels, neurogenesis in the dentate gyrus of the hippocampal formation and the cognitive function were evaluated in surviving mice. Survival time was significantly increased in running mice compared to control animals (p = 0.0087 in short-term and p = 0.016 in long-term experiments, log-rank test). At the end of the long-term experiment, mortality was lower in trained than in sedentary animals (p = 0.031, Fisher’s Exact test). Hippocampal neurogenesis – assessed by the density of doublecortin-, TUC-4- and BrdU + NeuN-colabeled cells - was significantly increased in running mice in comparison to the sedentary group after meningitis. However, Morris water maze performance of both groups 6 weeks after bacterial meningitis did not reveal differences in learning ability. In conclusion, physical exercise prior to infection increased survival in a mouse model of bacterial meningitis and stimulated neurogenesis in the dentate gyrus of the hippocampal formation.

show abstract

Evidence for frequent focal and diffuse acute axonal injury in human bacterial meningitis

Cited by 22 publications

References 0 publications

HIV encephalopathy: glial activation and hippocampal neuronal apoptosis, but limited neural repair

HIV encephalopathy: glial activation and hippocampal neuronal apoptosis, but limited neural repair

Septic metastatic encephalitis: coexistence of brain damage and repair

Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis

Contact Info

Product

Resources

About