Evidence for Free Radical Drug Ligands in class A G-protein Coupled Receptors

Gehrckens, Angela S; Horsfield, Andrew P.; Skoulakis, Efthimios M. C.; Turin, Luca

doi:10.1101/2021.08.30.458164

Cited by 2 publications

(3 citation statements)

References 41 publications

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“…More generally, a closer look at receptor mechanisms might offer some insights. Criticism of the vibration assisted tunnelling theory of olfaction often points to the fact that there isn't evidence for electron transfer in olfactory receptors, which are GPCRs 64 . However, a recent, as yet to be reviewed, paper suggests that there is the potential for electron transfer in certain types of GPCRs.…”

Section: The Specific Context Of Sars-cov-2mentioning

confidence: 99%

“…However, a recent, as yet to be reviewed, paper suggests that there is the potential for electron transfer in certain types of GPCRs. Various possibilities for the specific site of this electron transfer are explored in detail in the paper 64 . In the context of SARS-CoV-2, one of these is of particular interest: the disulfide bridge.…”

Section: The Specific Context Of Sars-cov-2mentioning

confidence: 99%

“…In particular it has looked at at how the spike protein vibronic mode might alter electron transfer in certain receptors. What many of these receptors potentially have in common is a disulfide bridge and the potential for redox activity 64,65 . Targeting the disulfide bonds has been shown to modulate host cell invasion 66 .…”

Section: Novel Therapies For Covid-19mentioning

confidence: 99%

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Bad vibrations: Quantum tunnelling in the context of SARS-CoV-2 infection

Adams,

Sinayskiy,

van Grondelle

et al. 2021

Preprint

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The SARS-CoV-2 pandemic has added new urgency to the study of viral mechanisms of infection. But while vaccines offer a measure of protection against this specific outbreak, a new era of pandemics has been predicted. In addition to this, COVID-19 has drawn attention to post-viral syndromes and the healthcare burden they entail.It seems integral that knowledge of viral mechanisms is increased through as wide a research field as possible. To this end we propose that quantum biology might offer essential new insights into the problem, especially with regards to the important first step of virus-host invasion. Research in quantum biology often centres around energy or charge transfer. While this is predominantly in the context of photosynthesis there has also been some suggestion that cellular receptors such as olfactory or neural receptors might employ vibration assisted electron tunnelling to augment the lockand-key mechanism. Quantum tunnelling has also been observed in enzyme function.Enzymes are implicated in the invasion of host cells by the SARS-CoV-2 virus. Receptors such as olfactory receptors also appear to be disrupted by COVID-19. Building on these observations we investigate the evidence that quantum tunnelling might be important in the context of infection with SARS-CoV-2. We illustrate this with a simple model relating the vibronic mode of, for example, a viral spike protein to the likelihood of charge transfer in an idealised receptor. Our results show a distinct parameter regime in which the vibronic mode of the spike protein enhances electron transfer. With this in mind, novel therapeutics to prevent SARS-CoV-2 transmission could potentially be identified by their vibrational spectra.

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Section: The Specific Context Of Sars-cov-2mentioning

confidence: 99%

Section: The Specific Context Of Sars-cov-2mentioning

confidence: 99%

See 1 more Smart Citation

Bad vibrations: Quantum tunnelling in the context of SARS-CoV-2 infection

Adams,

Sinayskiy,

van Grondelle

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Quantum tunnelling in the context of SARS-CoV-2 infection

Adams

Sinayskiy

Grondelle³

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The SARS-CoV-2 pandemic has added new urgency to the study of viral mechanisms of infection. But while vaccines offer a measure of protection against this specific outbreak, a new era of pandemics has been predicted. In addition to this, COVID-19 has drawn attention to post-viral syndromes and the healthcare burden they entail. It seems integral that knowledge of viral mechanisms is increased through as wide a research field as possible. To this end we propose that quantum biology might offer essential new insights into the problem, especially with regards to the important first step of virus-host invasion. Research in quantum biology often centres around energy or charge transfer. While this is predominantly in the context of photosynthesis there has also been some suggestion that cellular receptors such as olfactory or neural receptors might employ vibration assisted electron tunnelling to augment the lock-and-key mechanism. Quantum tunnelling has also been observed in enzyme function. Enzymes are implicated in the invasion of host cells by the SARS-CoV-2 virus. Receptors such as olfactory receptors also appear to be disrupted by COVID-19. Building on these observations we investigate the evidence that quantum tunnelling might be important in the context of infection with SARS-CoV-2. We illustrate this with a simple model relating the vibronic mode of, for example, a viral spike protein to the likelihood of charge transfer in an idealised receptor. Our results show a distinct parameter regime in which the vibronic mode of the spike protein enhances electron transfer. With this in mind, novel therapeutics to prevent SARS-CoV-2 transmission could potentially be identified by their vibrational spectra.

show abstract

Evidence for Free Radical Drug Ligands in class A G-protein Coupled Receptors

Cited by 2 publications

References 41 publications

Bad vibrations: Quantum tunnelling in the context of SARS-CoV-2 infection

Bad vibrations: Quantum tunnelling in the context of SARS-CoV-2 infection

Quantum tunnelling in the context of SARS-CoV-2 infection

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