Evidence for Follicle Wall Involvement in Ovulation and Progesterone Production by Frog (Rana pipiens) Follicles in vitro

Schuetz, Allen W.; Lessman, Charles A.

doi:10.1111/j.1432-0436.1982.tb01229.x

Cited by 44 publications

(16 citation statements)

References 27 publications

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“…However, the efficacy of surface epithelial removal was not confirmed (and numbers of ovulatory ovarian rupture points were reduced by scraping). Ovulation in frogs in vitro (Schuetz and Lessman, 1982) and sheep in vivo (Colgin and Murdoch, 1997) is blocked by surgical removal of the ovarian surface epithelium. Merely handling the surface of ovaries (which disrupts the surface epithelium) inhibits ovulation in pigs (Hall et al, 1993).…”

Section: Roles Of the Ovarian Surface Epithelium In Ovulation And Carmentioning

confidence: 99%

Roles of the ovarian surface epithelium in ovulation and carcinogenesis

Murdoch¹,

McDonnel²

2002

Reproduction

149

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The mammalian ovary is covered by a singular layer of epithelial cells. The rather unassuming character of the ovarian surface epithelium has generally inclined reproductive physiologists to question its functional significance. However, recent experimental evidence indicates that the ovarian epithelium is an obligate component of the ovulatory process. That most ovarian cancers arise by transformation of a surface epithelial cell affected by ovulation has been a point of theory for three decades. The objectives of this overview are to consider the morphology and developmental biology of the ovarian surface epithelium and to delineate its apparent roles in ovulation and pathogenesis. Anatomy and embryonic origin of the ovarian surface epitheliumOvarian surface epithelial cells vary in type from simple squamous to cuboidal to low pseudostratified columnar. The surface epithelium is supported over the ovarian cortical interstitium (tunica albuginea) by a basement membrane ( Fig. 1) and is held together laterally by desmosomes and gap or tight junctional complexes. Surface cells are continuous at the hilum with the mesothelium of the ovarian ligament (mesovarium) and peritoneum. Preferential outgrowth of a preovulatory follicle brings it into close apposition with the ovarian surface. In most mammals, the entire surface of the ovary, other than those regions disrupted by ovulation, is covered by epithelial cells. However, in equids, the ovarian epithelium (and ovulation) is restricted to a discrete area of depression known as the fossa, and the remainder of the ovary is encased by serosa-containing elastic bands of connective tissue (Walt et al., 1979). Ovarian surface epithelial cells have a mesodermal derivation shared with the epithelia of the urogenital system and adrenal cortex. Mesoderm segregates during embryonic development into pluripotent mesenchyme and coelomic epithelium (peritoneal mesothelium). Mullerian mesothelium is the precursor of oviductal, endometrial, and cervical epithelia. Ovarian surface epithelium differentiates after invagination of the coelomic mesothelium over the gonadal ridges (Byskov, 1986). In species with an ovulation fossa, the cortex (with modified epithelium) migrates into the medullary portion of the ovary during the postnatal period (Walt et al., 1979). Early investigators assumed that ova were derived from the ovarian surface; hence, the misnomer 'germinal' epithelium. Role of the ovarian surface epithelium in the mechanism of ovulatory follicular ruptureThe contention that ovarian surface epithelial cells participate actively in the biomechanics of gonadotrophin-induced Although ovarian mechanisms of ovulation have been a subject of investigation for more than a century, essential regulatory pathways remain uncertain. A role for the ovarian surface epithelium in ovulation has recently been demonstrated. Ovarian surface epithelial cells in close contact with the apical wall of preovulatory ovine follicles secrete a urokinasetype plasminogen activator in response to surge conc...

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Section: Roles Of the Ovarian Surface Epithelium In Ovulation And Carmentioning

confidence: 99%

Roles of the ovarian surface epithelium in ovulation and carcinogenesis

Murdoch¹,

McDonnel²

2002

Reproduction

149

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“…Indeed, at experimental level, the ovarian surface epithelium (OSE) has been found to play an important role: inhibition of ovulation by surgical ablation of surface epithelium in frog in vitro [11], and in sheep in vivo [12], along with proliferative ovarian epithelial activity located at the point of ovulatory trauma in rabbit [13]. Another argument in favour of this ovarian postulate is the high incidence of peritoneal carcinomatosis of ovarian origin in battery hens (repeated ovulation every 28 hours with a 30 to 40% spontaneous rate of peritoneal carcinosis at the age of 4 years) [14].…”

Section: High-grade Serous Ovarian Cancermentioning

confidence: 99%

Early Preinvasive Lesions in Ovarian Cancer

Chêne

Lamblin

Bail-Carval

et al. 2014

BioMed Research International

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Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development of new screening strategies. We discuss here the early natural history of ovarian cancer and its origins.

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“…L'ovulation est inhibé e par l'ablation chirurgicale de l'é pithé lium de surface ovarien chez les grenouilles in vitro [38], et chez les moutons in vivo [39]. La simple manipulation de la surface ovarienne (source de microtraumatisme de l'é pithé lium en raison de sa grande fragilité ) empêche l'ovulation chez les cochons [40].…”

Section: Arguments Expe´rimentauxunclassified