Evidence for Deficit in Tasks of Ventral, but not Dorsal, Prefrontal Executive Function as an Endophenotypic Marker for Bipolar Disorder

Frangou, Sophia; Haldane, Morgan; Roddy, Darren; Kumari, Veena

doi:10.1016/j.biopsych.2005.05.020

Cited by 118 publications

(90 citation statements)

References 13 publications

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“…Although current literature does not view such biases as primary endophenotypic markers of BD, both healthy pediatric BD offspring (Gotlib et al 2005) and adult siblings of BD patients exhibit affective processing biases toward negative stimuli in tasks of impulse control (Clark et al 2005;Klimes-Dougan et al 2006;Maziade et al 2009;Brand et al 2012). Similar to patients with BD, at-risk individuals display deficits in sustained attention and executive functioning (Zalla et al 2004;Frangou et al 2005;Klimes-Dougan et al 2006;Trivedi et al 2008;Kulkarni et al 2010;Diwadkar et al 2011) which suggests that cognitive deficits and affective processing biases could be interrelated, and may constitute markers of vulnerability to BD.…”

Section: Introductionmentioning

confidence: 99%

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Bauer

Frazier

Meyer

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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Background: Bipolar disorder (BD) is characterized by biased processing of emotional information. However, little research in this area has been conducted in youth with BD and at-risk individuals. The goal of this study was to determine whether children with BD displayed comparable or more severe manifestations of this bias relative to offspring of parents with BD. Materials and methods: The sample (n = 57 children and adolescents) included 18 individuals with BD (age: 13.63 -2.99; 8 females), 16 offspring of parents with BD (age: 11.83 -2.96; 9 females) and 23 healthy controls (HC) (age: 12.789 -3.087; 8 females). All participants performed the Affective Go/No-Go (AGN) and the Rapid Visual Processing (RVP) tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results: Relative to HC, individuals with BD responded faster to correct trials and committed an elevated number of commission errors across all affective conditions of the AGN task. By contrast, BD offspring showed intact performance accuracy but quicker response times than HC. Post-hoc analyses revealed that this behavioral pattern was observed in BD offspring with mental health problems but not in healthy BD offspring. Overall, mean reaction times and total number of errors in the RVP task were comparable across groups. Conclusions: In line with previous findings, subjects with BD encountered difficulties in processing affective information. The tendency toward faster but accurate responses to affective stimuli observed in BD offspring may be a marker of attentional bias toward affective information and constitute a vulnerability marker for mood disorder.

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Section: Introductionmentioning

confidence: 99%

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Bauer

Frazier

Meyer

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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“…As in other psychiatric disorders known for their influences and genetic bases, the inheritance pattern of bipolar disorder likely involves a complex interaction of several genes. Researchers have proposed possible chromosomal differences on chromosomes 2,4,5,6,8,9,10,12,13,14,15,18,21,22, and the X chromosome in people with bipolar disorder. Therefore, there are several candidate genes for the development of pathology.…”

Section: Genetic Vulnerability and Risk Factorsmentioning

confidence: 99%

“…The prefrontal areas are significant in cognitive function, especially executive functions, which may explain behavioral and neuropsychological changes (10) . Another specific difference observed in subjects affected by BD could be described by way of resonances, showing significant loss of asymmetry of the left/right caudate nucleus and in the right anterior frontal region.…”

Section: Neuroscience Of Bipolar Mood Disordermentioning

confidence: 99%

“…In three analyses of the endophenotype of bipolar disorder with patients, unaffected first-degree relatives (fathers, mothers, brothers, twins, and children), and control targets, the endophenotype markers were shown through neuropsychological measures (10,33) . However, a meta-analysis claims that these findings should be interpreted with caution, as it is very likely that the confusion of factors such as medication, chronicity, and affective symptoms below the threshold are also contributing to the observed results (34) .…”

Section: Neuropsychology Of Bipolar Disordermentioning

confidence: 99%

“…In this sense, they would present both as a feature of clinical manifestations and a feature of neurodevelopment, meaning that they would be present even before the emergence of BD (32) . In the period of euthymia, cognitive impairments are also observed in sustained attention (37) , declarative memory (35) , verbal memory (31) , the recognition of facial expressions (32) , the capacity for learning (35) , difficulties in recovery (32) , and the organization of information (10) . The scientific literature indicates significant differences in several cognitive domains between bipolar patients and controls and unaffected first-degree relatives.…”

Section: Neuropsychology Of Bipolar Disordermentioning

confidence: 99%

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Model endophenotype for bipolar disorder: Qualitative Analysis, etiological factors, and research areas

Tavares

Neves

Malloy-Diniz

2014

Rev. esc. enferm. USP

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Modelo de endofenótipo do transtorno Bipolar: análise qualitativa, fatores etiológicos e âMBitos de investigação aBordados Modelo endofenotipo de trastorno Bipolar: análisis cualitativo, factores etiológicos y las áreas para las cuales la investigación 1 professor of psychology, school of education, federal university of goiás and doctoral student of the post graduate program in neurosciences at the federal university of Minas gerais, Belo Horizonte, Brazil. AbSTrAcTThe aim of this study is to present an updated view of the writings on the endophenotype model for bipolar disorder using analytical methodologies. A review and analysis of networks was performed through descriptors and keywords that characterize the composition of the endophenotype model as a model of health. Information was collected from between 1992 and 2014, and the main thematic areas covered in the articles were identified. We discuss the results and question their cohesion, emphasizing the need to strengthen and identify the points of connection between etiological factors and characteristics that make up the model of endophenotypes for bipolar disorder. DeScripTOrSEndophenotypes Bipolar disorders Health models Analysis qualitative reSuMeN El objetivo de este trabajo es presentar una visión actualizada de los escritos del modelo endofenotipo para el trastorno bipolar, el uso de las metodologías analíticas. Se realizó una revisión de este tipo de literatura y un análisis de las redes a través de descriptores y palabras clave que caracterizan la composición del modelo endofenotipo como modelo de salud. El momento de la recolección de la información se produjo entre los años 1992-2014, la identificación de las principales áreas temáticas incluidas en los artículos. Se discuten los resultados para la consolidación del modelo de endofenotipos, cuestionando la cohesión y haciendo hincapié en la necesidad de fortalecer e identificar los puntos de conexión entre los factores etiológicos y característi-cas que conforman el modelo de endofenotipos para el trastorno bipolar. DeScripTOreS

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Bipolar Disorder

Blader,

Roybal,

Sauder

et al. 2017

Child and Adolescent Psychopathology, Third Edition

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Evidence for Deficit in Tasks of Ventral, but not Dorsal, Prefrontal Executive Function as an Endophenotypic Marker for Bipolar Disorder

Cited by 118 publications

References 13 publications

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Model endophenotype for bipolar disorder: Qualitative Analysis, etiological factors, and research areas

Bipolar Disorder

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