Evidence for clinical interventions targeting the gut microbiome in cardiometabolic disease

Ghosh, Tarini Shankar; Valdes, Ana Maria

doi:10.1136/bmj-2023-075180

Cited by 8 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of culture‐independent methods allowed the rigorous identification of the complete repertoire of microbes present in a particular sample, and this technological improvement led to the realization that the human gut microbiome displayed altered composition and function in a wide range of pathophysiologies and syndromes (reviewed in Lynch & Pedersen, 2016 ). Examples of non‐communicable diseases in which an altered microbiome has been implicated include inflammatory bowel disease (Lavelle & Sokol, 2020 ), irritable bowel syndrome (Jeffery et al., 2020 ), type 2 diabetes (Pedersen et al., 2016 ), obesity (Cani & Van Hul, 2023 ), liver disease (Adolph et al., 2018 ), cardiometabolic disease (Ghosh & Valdes, 2023 ) and colon cancer (Marchesi et al., 2011 ). Mechanisms by which the microbiome may exert these disease‐promoting effects can be assigned to a number of broad categories that include effects on homeostatic control of metabolic, immune or neurological functions (reviewed in ref.…”

Section: The Microbiome As a Modulator Of Non‐communicable Disease Riskmentioning

confidence: 99%

Ageing, microbes and health

O'Toole

2024

Microbial Biotechnology

View full text Add to dashboard Cite

The human gut microbiome is a modifier of the risk for many non‐communicable diseases throughout the lifespan. In ageing, the effect of the microbiome appears to be more pronounced because of the lower physiological reserve. Microbial metabolites and other bioactive products act upon some of the key physiological processes involved in the Hallmarks of Ageing. Dietary interventions that delay age‐related change in the microbiome have also led to delayed onset of ageing‐related health loss, and improved levels of cognitive function, inflammatory status and frailty. Cross‐sectional analysis of thousands of gut microbiome datasets from around the world has identified key taxa that are depleted during accelerated health loss, and other taxa that become more abundant, but these signatures differ in some geographical regions. The key challenges for research in this area are to experimentally prove that particular species or strains directly contribute to health‐related ageing outcomes, and to develop practical ways of retaining or re‐administering them on a population basis. The promotion of a health‐associated gut microbiome in ageing mirrors the challenge of maintaining planetary microbial ecosystems in the face of anthropogenic effects and climate change. Lessons learned from acting at the individual level can inform microbiome‐targeting strategies for achieving Sustainable Development Goals at a global level.

show abstract

Section: The Microbiome As a Modulator Of Non‐communicable Disease Riskmentioning

confidence: 99%

Ageing, microbes and health

O'Toole

2024

Microbial Biotechnology

View full text Add to dashboard Cite

show abstract

“…Additionally, the significance of ongoing clinical trials in elucidating the interplay between baseline microbiome composition and intervention efficacy is underscored. 39 These trials pave the way for tailored approaches to T2DM management, leveraging insights into individual gut microbiota dynamics.…”

Section: Clinical Evidence For Gut Microbiota Modulation In T2dmmentioning

confidence: 99%

Modulating gut microbiota in the management of type 2 diabetes mellitus: a narrative review

Tousif,

Akhtar

2024

Int J Res Med Sci

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) represents a significant global health burden, necessitating innovative therapeutic approaches. Recent research has increasingly recognized the role of gut microbiota modulation in T2DM management, offering promising avenues for intervention. This systematic review synthesizes current literature investigating the impact of modulating gut microbiota on T2DM management. A comprehensive search of databases yielded studies examining various strategies, including probiotics, prebiotics, dietary interventions, and facal microbiota transplantation. Analysis of these interventions revealed their potential to improve glycemic control, insulin sensitivity, and inflammation markers in individuals with T2DM. Mechanistic insights elucidate how gut microbiota modulation influences metabolic pathways, immune function, and gut barrier integrity, thereby contributing to T2DM pathophysiology. Furthermore, studies highlight the interplay between gut microbiota composition and host factors such as diet, lifestyle, and genetics, underscoring the complexity of this relationship. Modulating gut microbiota presents a promising therapeutic approach in T2DM management, with potential benefits in glycemic control and metabolic health. However, further research is warranted to optimize intervention strategies, elucidate mechanistic pathways, and explore long-term effects. The aim of this review was to underscores the importance of considering gut microbiota modulation as a complementary approach in the multifaceted management of T2DM.

show abstract

“… 8 And despite the depth of basic research establishing the effect of microbial metabolites on human health, Valdes and Ghosh highlight that we still have little evidence from clinical trials examining the effect of manipulating the gut microbiome on disease specific outcomes. 9 …”

Section: Acting On Imperfect Evidencementioning

confidence: 99%

Challenges of obesity and type 2 diabetes require more attention to food environment

Ladher,

Hinton,

Veitch

2023

BMJ

View full text Add to dashboard Cite

show abstract

Evidence for clinical interventions targeting the gut microbiome in cardiometabolic disease

Abstract: Tarini Shankar Ghosh and Ana Maria Valdes evaluate the evidence for clinical effects of microbiome altering interventions on cardiometabolic traits

Cited by 8 publications

References 25 publications

Ageing, microbes and health

Ageing, microbes and health

Modulating gut microbiota in the management of type 2 diabetes mellitus: a narrative review

Challenges of obesity and type 2 diabetes require more attention to food environment

Contact Info

Product

Resources

About