Evidence for Cholesterol Hyperabsorbers and Hyperproducers Based on Comparative Low-Density Lipoprotein Reductions Achieved by Ezetimibe Versus Statins

Senaratne, Janek; Griffiths, Jo; MacDonald, Karen; Senaratne, M. P. J.

doi:10.1097/hcr.0b013e31825d29ee

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Moreover, studies which monitored plasma cholesterol levels have shown that individuals vary significantly in their responses to dietary cholesterol [44], [45], possibly due to intrinsic differences in cholesterol absorption [46] and have resulted in normolipidemic individuals being classified as either hypo or hyper responsders [47], [48]. Similarly, it has recently been suggested that certain individuals are hyperproducers of cholesterol while others are hyperabsorbers [49]. These findings endorse the view that regulation of whole-body lipid metabolism is underpinned by a variety of extrinsic and intrinsic factors acting simultaneously.…”

Section: Lipid Metabolism and Healthy Agingmentioning

confidence: 99%

Computationally Modeling Lipid Metabolism and Aging: A Mini-review

Auley

Mooney

2015

Computational and Structural Biotechnology Journal

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One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increase in the global population of older people. Aging western populations have resulted in a rise in the prevalence of age-related pathologies. Of these diseases, cardiovascular disease is the most common underlying condition in older people. The dysregulation of lipid metabolism due to aging impinges significantly on cardiovascular health. However, the multifaceted nature of lipid metabolism and the complexities of its interaction with aging make it challenging to understand by conventional means. To address this challenge computational modeling, a key component of the systems biology paradigm is being used to study the dynamics of lipid metabolism. This mini-review briefly outlines the key regulators of lipid metabolism, their dysregulation, and how computational modeling is being used to gain an increased insight into this system.

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Section: Lipid Metabolism and Healthy Agingmentioning

confidence: 99%

Computationally Modeling Lipid Metabolism and Aging: A Mini-review

Auley

Mooney

2015

Computational and Structural Biotechnology Journal

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“…People also differ in terms of the intensity of cholesterol synthesis (Lecerf and Lorgeril, 2011). Some people may be hyperabsorbers of cholesterol while others may be hyperproducers (Senaratne et al, 2012).…”

Section: Dietary Cholesterolmentioning

confidence: 99%

Exclusion of Dietary Cholesterol from The Specific Food Restrictions: A Review in Indonesia

Zulkarnain¹

2018

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Hypercholesterolemia, the presence of high levels of cholesterol in the blood, is one of the major risk factor for cardiovascular disease (CVD). One of the key recommendation in the Dietary Guidelines for Americans 2010, is to consume less than 300 mg of dietary cholesterol per day. The same amount is also adopted in Indonesia (BPOM, 2016) until today. However, in the latest Dietary Guidelines for Americans 2015-2020, dietary cholesterol is no longer included in the list of specific foods that should be limited. The added sugars, sodium, saturated fats and trans fats remain on the list of food components that should be reduced. Generally, foods that are higher in dietary cholesterol are also higher in saturated fats. But there are also some foods that are higher in cholesterol but not in saturated fats. According to the latest recommendation, this kind of foods can be consumed without any specific restriction. In this review, some of clinical studies related to the association between dietary cholesterol and blood cholesterol levels are selected. The findings from those studies will be summarized to consider whether the same recommendation should be implemented in other countries, especially in Indonesia.

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Effectiveness of a combination of ezetimibe and statins in patients with acute coronary syndrome and multiple comorbidities: A 6-year population-based cohort study

Wang

et al. 2017

International Journal of Cardiology

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Evidence for Cholesterol Hyperabsorbers and Hyperproducers Based on Comparative Low-Density Lipoprotein Reductions Achieved by Ezetimibe Versus Statins

Cited by 4 publications

References 6 publications

Computationally Modeling Lipid Metabolism and Aging: A Mini-review

Computationally Modeling Lipid Metabolism and Aging: A Mini-review

Exclusion of Dietary Cholesterol from The Specific Food Restrictions: A Review in Indonesia

Effectiveness of a combination of ezetimibe and statins in patients with acute coronary syndrome and multiple comorbidities: A 6-year population-based cohort study

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