Evidence for calcium-sensing receptor mediated stanniocalcin secretion in fish

Radman, Dennis P.; McCudden, Christopher R.; James, Kathi; Nemeth, Edward M; Wagner, Graham F.

doi:10.1016/s0303-7207(01)00643-8

Cited by 55 publications

(46 citation statements)

References 30 publications

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“…These general patterns of distribution are mirrored specifically, and further extended, in fishes. CaR is detected in the kidney (including the endocrine corpuscles of Stannius) and urinary bladder, alimentary tract, and gills of several species (sea bream; winter flounder, Pseudopleruonectes americanus; Atlantic salmon, Salmo salar; rainbow trout, Oncorhynchus mykiss; and dogfish shark), and in the secretory shark rectal gland (13,14,17,18). In the brain of fishes, CaR is localized in several regions, including the pituitary gland and olfactory tissues (13,14), and in the European flounder (Platichthys flesus), "CaR protein" has been localized to Dahlgren cells of the caudal neurosecretory system (16).…”

Section: Resultsmentioning

confidence: 99%

“…Renal and urinary blad-der effects of caudal neurosecretory system-derived hormones may be expected in fishes, because the caudal vein, which receives these hormonal secretions, delivers blood to these iontransporting tissues (52). Although these data from Dahlgren cells are circumstantial, there is more direct evidence from the rainbow trout where both extracellular Ca 2ϩ and the calcimimetic NPS R-467 stimulated the release of the teleost hypocalcemic hormone stanniocalcin from the corpuscles of Stannius, and reduced radiocalcium uptake across the gills (17,53).…”

Section: Resultsmentioning

confidence: 99%

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cDNA Cloning and Functional Expression of a Ca2+-sensing Receptor with Truncated C-terminal Tail from the Mozambique Tilapia (Oreochromis mossambicus)

Loretz¹,

Pollina

Hyodo

et al. 2004

Journal of Biological Chemistry

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The complete cDNA sequence of the tilapia extracellular Ca 2؉ -sensing receptor (CaR) was determined. The transcript length of tilapia CaR (tCaR) is 3.4 kbp and encodes a 940-amino acid, 7-transmembrane domain protein that is consistent in its structural features with known mammalian and piscine CaRs. The tCaR extracellular domain includes a characteristic hydrophobic segment, conserved cysteine residues that are implicated in receptor dimerization (Cys 129 and Cys 131 ) and in coupling to the transmembrane domain (nine conserved cysteine residues), and conserved serine residues (Ser 147 and The roles for ionic calcium (Ca 2ϩ ) in physiological functions are many and varied and essential for survival. Ca 2ϩ -dependent cellular processes include hormone secretion (stimulussecretion coupling), excitability and cell motility (excitationcontraction coupling), and neurotransmission (Ca 2ϩ -based action potentials). This critical involvement of Ca 2ϩ in these and other cellular functions is unique among ions. Ca 2ϩ is simultaneously a controlled variable in physiological systems, an extracellular messenger in multicellular organisms, and an intracellular mediator in a variety of effector cells.Unicellular organisms acquire Ca 2ϩ from the external environment; they have little control over the composition of the surrounding medium and thus had to evolve plasma membrane-bound and other cellular mechanisms to realize cellular Ca 2ϩ homeostasis eventually permitting some degree of habitat survival and selection. In multicellular organisms, active regulation by integumentary tissues of the composition of an "extracellular fluid," which bathes all cells, assures a constant internal milieu and contributes to normal Ca 2ϩ -dependent cell functions. In terrestrial vertebrates, Ca 2ϩ homeostasis depends upon appropriate dietary intake, renal output, and osseous storage and mobilization of Ca 2ϩ . These processes are well known and are regulated by parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D acting on kidney, intestine, and bone. Activation of the Ca 2ϩ -sensing receptor (CaR) 1 by its natural ligand, extracellular Ca 2ϩ , alters parathyroid hormone and calcitonin secretion and inhibits renal 1-hydroxylase to retard the synthesis of 1,25-dihydroxyvitamin D (1, 2). Ca 2ϩ balance is achieved through regulated calciotropic hormone secretion in response to the extracellular Ca 2ϩ concentration ([Ca 2ϩ ] o ); the secreted hormones, in turn, control the activity of Ca 2ϩ -transporting tissues to bring about alterations in [Ca 2ϩ ] o . Interestingly, in fishes, the calcium homeostatic process involves ion-transporting tissues not represented in other vertebrate classes (viz., the mitochondria-rich "chloride cells" of the gills and skin) and a different panel of hormones (prolactin and somatolactin from the pituitary, and stanniocalcin from the piscine corpuscles of Stannius (3)). Opportunities for cutaneous

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

cDNA Cloning and Functional Expression of a Ca2+-sensing Receptor with Truncated C-terminal Tail from the Mozambique Tilapia (Oreochromis mossambicus)

Loretz¹,

Pollina

Hyodo

et al. 2004

Journal of Biological Chemistry

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“…Therefore, the changes in ECaC mRNA expression observed in this study could reflect sensing of ambient and/or internal Ca 2ϩ . The presence of a Ca 2ϩ -sensing receptor (CaR) has been demonstrated in the trout gill (34), and thus it is conceivable that CaR is involved in the sensing of low ambient Ca 2ϩ levels and the initiation of events leading to increased transcription of ECaC. Furthermore, it is well established that increased levels of internal Ca 2ϩ can be sensed and can lead to downstream effects to reduce branchial Ca 2ϩ uptake (19).…”

Section: Low Environmental Camentioning

confidence: 99%

Hormonal and environmental regulation of epithelial calcium channel in gill of rainbow trout (Oncorhynchus mykiss)

Shahsavarani

Perry

2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…It has recently been shown that the Ca 2+ -stimulated STC secretion is mediated by a Ca 2+ ion-sensing receptor (Radman et al 2002). In addition to triggering STC secretion, elevated extracellular Ca 2+ increases STC mRNA in cultured CS cells (Wagner & Jaworski 1994) Wagner 1995).…”

Section: Regulation Of Stc1 Mrna Expressionmentioning

confidence: 99%

Mammalian stanniocalcins and cancer.

Chang

Jellinek²,

Reddel

2003

Endocrine-Related Cancer

145

129

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Stanniocalcin (STC) is a glycoprotein hormone that is secreted by the corpuscle of Stannius, an endocrine gland of bony fish, and is involved in calcium and phosphate homeostasis. The related mammalian proteins, STC1 and STC2, are expressed in a wide variety of tissues. The ovaries have the highest level of STC1, and this increases during pregnancy and lactation. STC1 is present in breast ductal epithelium, and its expression is induced by BRCA1, a tumor suppressor gene that has an important role in breast and ovarian cancer. The expression of STC2 is induced by estrogen, and there is a positive correlation between the level of expression of estrogen receptor and expression of both STC1 and STC2 in breast cancer. This article reviews the data currently available regarding the mammalian STCs, and discusses the roles they may play in normal physiology and in breast and other cancers.

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Evidence for calcium-sensing receptor mediated stanniocalcin secretion in fish

Cited by 55 publications

References 30 publications

cDNA Cloning and Functional Expression of a Ca2+-sensing Receptor with Truncated C-terminal Tail from the Mozambique Tilapia (Oreochromis mossambicus)

cDNA Cloning and Functional Expression of a Ca2+-sensing Receptor with Truncated C-terminal Tail from the Mozambique Tilapia (Oreochromis mossambicus)

Hormonal and environmental regulation of epithelial calcium channel in gill of rainbow trout (Oncorhynchus mykiss)

Mammalian stanniocalcins and cancer.

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