Evidence for biogenic amine receptors in toad sciatic nerves

Sabelli, Hector; Gorosito, M.

doi:10.1016/0028-3908(69)90069-0

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…12 It has been suggested that adrenergic receptors may be present in amphibian peripheral nerve fibers by showing that impulse conduction in these fibers was modulated by various forms of adrenergic agents. 13,14 There is evidence to suggest that ␣ 2adrenergic receptors can be expressed abnormally in mammalian primary sensory neurons in chronic neuropathic states. 15,16 In support of this, it has been found that an expression of mRNA for a subtype of ␣ 2 -adrenergic receptors increases in rat dorsal root ganglion cells after peripheral nerve injury.…”

Section: Fig 3 Effects Of Different Concentrations Of Idazoxan Onmentioning

confidence: 99%

Conduction block by clonidine is not mediated by α2-adrenergic receptors in rat sciatic nerve fibers

Leem

Han²,

Yoon³

et al. 2000

Regional Anesthesia and Pain Medicine

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The results indicated that the mixture of clonidine and yohimbine, in which either drug inhibited impulse conduction, produced conduction block in an additive manner, and that clonidine-induced conduction block was not reversed by coapplication with a specific alpha(2)-adrenergic antagonist idazoxan. These data suggest that clonidine's effects likely depend on mechanisms not mediated by alpha(2)-adrenergic receptors.

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Section: Fig 3 Effects Of Different Concentrations Of Idazoxan Onmentioning

confidence: 99%

Conduction block by clonidine is not mediated by α2-adrenergic receptors in rat sciatic nerve fibers

Leem

Han²,

Yoon³

et al. 2000

Regional Anesthesia and Pain Medicine

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show abstract

“…In fact. the axonal effects of cocaine (Lorente de N6, 1947) and other local anesthetics (Condouris, 1961;Sabelli and Gorosito, 1969) are antagonized by increasing the Na concentration in the medium. However, we found, that in contrast to local anesthetics, the axonal effects of these barbiturates are increased by decreasing' their degree of ionization; this…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Phenobarbital and Pentobarbital on Isolated Nervous Tissue

1975

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Epileptiform after discharges evoked by repetitive electrical stimulation of chronically isolated cortical slabs (cat) were shortened by low doses of phenobarbital but not affected by hypnotic doses of pentobarbital. Both pentobarbital and phenobarbital raised threshold and lowered spike amplitude in isolated sciatic nerves. The action of both drugs was increased by reducing Na in the medium and by decreasing the Ringer's pH. Similar to the action of other general anesthetics, the axonal effect of pentobarbital was enhanced by D2O replacement for H2O in the Ringer's (suggesting that tissue water is involved in pentobarbital action), whereas D2O replacement did not modify the action of phenobarbital or of local anesthetics. These results suggest that the varying in vivo effects of pentobarbital and phenobarbital may be due to a difference in their action upon excitable membranes (rather than to a different regional distribution in brain).

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Possible role of 2-phenylethylamine in the modulation of extrapyramidal function

Sabelli

Mosnaim

Borison

et al. 1976

Drugs and Central Synaptic Transmission

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Evidence for biogenic amine receptors in toad sciatic nerves

Cited by 9 publications

References 16 publications

Conduction block by clonidine is not mediated by α2-adrenergic receptors in rat sciatic nerve fibers

Conduction block by clonidine is not mediated by α2-adrenergic receptors in rat sciatic nerve fibers

Differential Effects of Phenobarbital and Pentobarbital on Isolated Nervous Tissue

Possible role of 2-phenylethylamine in the modulation of extrapyramidal function

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