Evidence for antioxidants consumption in the coronary blood of patients with an acute myocardial infarction

Guérin, Patrice; Bigot, Edith; Patrice, Thierry

doi:10.1007/s11239-012-0774-y

Cited by 8 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This could be related to an overconsumption of antioxidants present physiologically in healthy persons during pathological situations—i.e., tumor growth or submission to a risk factor like tobacco. The non-significant SOS increase in withdrawn smokers had been also found in other non-cancer-related studies [40]. One could imagine that smoking induces mobilization of non-spontaneously present antioxidative defense to maintain homeostasis, stopping with smoking arrest but induced metabolic damages persisting.…”

Section: Discussionsupporting

confidence: 63%

Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background: Singlet oxygen (1O2) oxidizes targets through the production of secondary reactive oxygen species (SOS). Cancers induce oxidative stress changing with progression, the resulting antioxidant status differing from one patient to the other. The aim of this study was to determine the oxidative status of patients with resectable Non-Small cell lung cancers (NSCLC) and the potential influence of antioxidants, compared to sera from healthy donors. Materials and Methods: Serum samples from 10 women and 28 men, 19 adenocarcinomas (ADK), 15 patients N1 or M1 were submitted to a photoreaction producing 1O2. Then, samples were supplemented with vitamins (Vit C, Vit E), or glutathione (GSH). Results: Squamous cell carcinomas (SCC) and metastatic SCCs induced a lower SOS rate. While Vit C increased SOS in controls as in patients with metastases, Vit E or the combination of Vit E and C strongly reduced SOS. GSH alone lightly decreased SOS in controls but had no effect in patients either alone or combined with Vit C. Conclusion: In “early” lung cancers, SOS are comparable or lower than for healthy persons. The role of Vitamins varies with gender, cancer type, and metastases. This suggests that an eventual supplementation should be performed on a per-patient basis to evidence any effect.

show abstract

Section: Discussionsupporting

confidence: 63%

Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…6 Recently, Guerin et al reported that oxidants were increased in occluded vessels during AMI, demonstrating that antioxidants were consumed. 7 It was also demonstrated that oxidative stress was an independent predictor for no-reflow phenomenon following pPCI in patients with STEMI. 8 Although relationship between oxidative stress and coronary flow dynamics is well known in patients with coronary slow flow and STEMI following pPCI, 8,20 this relationship has not been not investigated in patients with STEMI with and without SR before pPCI.…”

Section: Discussionmentioning

confidence: 98%

“…12 Moreover, ischemia results in impaired antioxidant defense system in patients with STEMI. 7,24 Therefore, oxidative stress may facilitate thrombus formation leading to total occlusion in IRA and also oxidative stress may be increased as a result of the total occlusion in IRA. The present study also showed that pre-pPCI SR of IRA was associated with neutrophil to lymphocyte ratio, MPV, uric acid, and Killip class 2 to 4 besides oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] Oxidative stress, defined as the impaired balance between oxidant and antioxidant systems, plays a crucial role in the pathogenesis of both atherosclerosis and acute coronary syndromes including STEMI. [6][7][8] Although total antioxidant status (TAS) reflects the total effect of all antioxidants in the plasma and body, 9 total oxidant status (TOS) shows the total effect of all oxidants. 10 Oxidative stress is one of the major contributors to atherosclerotic plaque instability with inflammation process.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction

Börekçi

Gür

Türkoğlu³

et al. 2014

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

In the pathogenesis of atherosclerosis, oxidative stress plays a major role in plaque instability, rupture, and erosion, which subsequently leads to thrombus formation and causes total infarct-related artery (IRA) occlusion. We investigated the relationship between spontaneous reperfusion (SR) of IRA and oxidative stress in patients with anterior ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. A total of 341 consecutive patients with anterior STEMI were prospectively included in the present study. Patients were divided into 2 groups according to their thrombolysis in myocardial infarction (TIMI) flow grade: SR group (66 patients, TIMI flow 3) and non-SR group (275 patients, TIMI flow 0-2). On multivariate logistic regression analysis, oxidative stress index (β = 0.868, 95% confidence interval [CI] = 0.806-0.934, P < .001), neutrophil to lymphocyte ratio, uric acid, mean platelet volume, Killip 2 to 4 class, and initial SYNTAX score were independently associated with SR. Oxidative stress as well as inflammation may play a pivotal role in the pathogenesis of SR in patients with STEMI.

show abstract

“…It may also achieve its effects through an antioxidative mechanism. Oxygen-derived free radicals are believed to participate in ischemic injury to the heart (52)(53)(54). However, while the lignan component of flaxseed (secoisolariciresinol diglucoside [SDG]) has marked antioxidative effects (55,56), SDG is not absorbed from a flaxseedsupplemented diet.…”

Section: Animal Research Demonstrating the Cardioprotective Effects Omentioning

confidence: 99%

The potential for using alpha-linolenic acid as a therapy for cardiovascular disease

Blackwood¹,

Leyva²

2014

Curr Res Cardiol

View full text Add to dashboard Cite

Many natural food products possess a significant source of health benefit beyond normal nutrition. In recent years, a field of study has emerged that focuses on elucidating the beneficial or deleterious effects that specific foods and diets may have on various disease processes. One area of investigation is the role that specific nutrients play in the prevention of chronic cardiovascular disease (CVD) (1). Largescale animal and human trials continue to identify the central importance of how different food sources affect modifiable cardiac risk factors such as diabetes, obesity and inflammation (2,3), diseases that are now reaching epidemic proportions. One example of a diet-based clinical study that has changed foodintake guidelines to benefit cardiovascular health is the Dietary Approaches to Stop Hypertension (DASH) trial (4). The DASH trial compared a typical Western diet with a diet rich in fruits, vegetables, low-fat dairy products and low in saturated fats. After two weeks of intervention, systolic blood pressure decreased significantly by 5.5 mmHg compared with the control Western diet (4,5). This study demonstrates how simple alterations to a typical Western diet may result in a direct, positive net effect on health and the reduction of cardiovascular risk factors. Diet may also have significant implications in both the costs and benefits of long-term human health. As a result, many natural products that contain myriad properties that may directly influence chronic disease processes have been identified. Natural products that have been proven to elicit positive health effects are termed either 'nutraceuticals' or 'functional foods'. As defined by Health Canada, a nutraceutical is "a product isolated or purified from foods that is generally sold in medicinal forms not usually associated with food. A nutraceutical is demonstrated to have a physiological benefit or provide protection against chronic disease", whereas a "functional food is similar in appearance to, or may be, a conventional food, is consumed as part of a usual diet, and is demonstrated to have physiological benefits and/or reduce the risk of chronic disease beyond basic nutritional functions" (6). Several nutraceuticals and functional foods have been shown to improve cardiovascular health (7,8).

show abstract

Evidence for antioxidants consumption in the coronary blood of patients with an acute myocardial infarction

Cited by 8 publications

References 34 publications

Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction

The potential for using alpha-linolenic acid as a therapy for cardiovascular disease

Contact Info

Product

Resources

About