Evidence for antioxidant nutrients‐induced pigmentation in skin: Results of a clinical trial

Postaire, E.; Jungmann, H; Bejot, Marie; Heinrich, Ulrike; Tronnier, H

doi:10.1080/15216549700203481

Cited by 19 publications

(22 citation statements)

References 11 publications

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“…Side effects: NR Postaire et al 1997 [36] The role of antioxidant nutrient intakes on pigmentation of the skin without any UV exposure. Supplement 1 (B13/L2): 2 capsules containing 5mg natural totopherol, 30mg ascorbic acid, 13mg β-carotene and 2mg lycopene.…”

Section: N Between Groupsmentioning

confidence: 99%

“…Thirteen studies had two intervention arms (control/intervention) [25][26][27][29][30][31][32][33][34][35][36][37][38], two had one arm [29] , one had three [39] and one had six intervention arms [28]. The majority of studies (15 out of 17) evaluated the effect of various dietary supplements with several active…”

Section: Effectiveness Of Dietary Interventions On Appearancementioning

confidence: 99%

“…Polyphenols [27,39], Omega 3 fatty acids [27,32,39], carotenoids [21], [32,36], [27,37] , vitamins E [27,36,37,39] and C [36] [27,37], Lactobacillus (La1) probiotics [29], green tea polyphenols [25,30,33], squalene [31], red ginseng [26] , and flavanol cocoa [34], whilst only one measured the effect derived from whole foods [28] which used foods high in beta-carotene.…”

Section: Effectiveness Of Dietary Interventions On Appearancementioning

confidence: 99%

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Can dietary intake influence perception of and measured appearance? A Systematic Review

et al. 2015

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Appearance-based interventions have had some success in reducing smoking and sun exposure. Appearance may also motivate dietary behavior change if it was established that dietary improvement had a positive impact on appearance. The aims of this review are to evaluate the current evidence examining the relationship between dietary intake and appearance and to determine the effectiveness of dietary interventions on perceived or actual appearance. An electronic search of English language studies up to August 2012 was conducted using Cochrane, MEDLINE, Embase, CINAHL, Web of Science, SCOPUS and PsycINFO databases. Studies that included participants aged ≥ 18 years, that observed or altered dietary intake from actual food or dietary supplement use and assessed appearancerelated outcomes were considered eligible. Data from 27 studies were extracted and assessed for quality using standardized tools. Nineteen studies were assessed as being of "positive" and four of "neutral" quality. All observational studies (n=4741 participants) indicated that there was a significant association between various aspects of dietary intake and skin coloration and skin aging. The majority (16 studies, 769 participants) evaluated the effect of dietary supplements on skin appearance amongst females. Only one study examined the effect of actual food intake on appearance. Significant improvements in at least one actual or perceived appearance-related outcome (facial wrinkling, skin elasticity, roughness and skin color) following dietary intervention were shown as a result of supplementation. Further studies are needed in representative populations that examine actual food intake on appearance, using validated tools in a well-designed high quality RCTs.

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Section: N Between Groupsmentioning

confidence: 99%

Section: Effectiveness Of Dietary Interventions On Appearancementioning

confidence: 99%

Section: Effectiveness Of Dietary Interventions On Appearancementioning

confidence: 99%

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Can dietary intake influence perception of and measured appearance? A Systematic Review

et al. 2015

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“…Both extracts were tested in different concentrations at a ratio of 5:1 for TE and PE in combination with vitamin E and vitamin C (COMB). Concentrations of vitamins E (35 ÌM ) and C (100 ÌM ) and the extracts were based on the in vitro and in vivo experiments reported by others [5,10]. The effects were studied during one and repeated passages (short-and long-term incubations).…”

Section: Cell Culturementioning

confidence: 99%

“…Dietary carotenoids have been reported to be partly responsible for the skin colour [4]. There are also indications that some dietary supplements with vitamins E and C and the carotenoids ß-carotene and lycopene can induce melanin pigmentation of the skin [5].…”

Section: Introductionmentioning

confidence: 99%

The Combined Effects of Extracts Containing Carotenoids and Vitamins E and C on Growth and Pigmentation of Cultured Human Melanocytes

Smit¹,

Vic̀anová

Cramers³

et al. 2004

Skin Pharmacol Physiol

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In the present study, we investigated the effects of tomato extract (TE) containing lycopene and palm fruit extract (PE) rich in carotenoids on the growth and pigmentation of melanocyte cultures of Caucasian origin. The extracts were tested at different concentrations and in combination with vitamins E and C. Melanocytes with basic and increased (tyrosine-induced) pigmentation were treated in short-term and long-term experiments. Prevention of UVA-induced DNA damage was studied by using the comet assay. Melanocytes with stimulated melanin production showed reduced growth. Incubation of the cells with TE/PE (20/4 µg/ml) in combination with 35 µM vitamin E and 100 µM vitamin C (COMB 20/4) reduced this growth inhibition, especially in the long-term cultures. Increased production of melanin pigment was obtained when the cells were treated with 2.5 × and 10 × higher concentrations of the TE/PE and the same concentration of vitamins E and C (COMB 50/10 and 200/40). Reduced DNA damage was found after UVA irradiation in cells preincubated with COMB 50/10. The results indicate that the presence of carotenoids from TE and PE in combination with vitamins E and C may influence growth and pigmentation in melanocyte monocultures. Depending on the concentration of the carotenoid mixtures, their presence may provide some protection against the melanogenic intermediates and/or exogenous DNA damage.

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Quercetin Inhibits α‐MSH‐stimulated Melanogenesis in B16F10 Melanoma Cells

Yang

Son

Lee

et al. 2011

Phytotherapy Research

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Quercetin is known to inhibit tyrosinase activity and melanin production in melanocytes. However, several reports suggest that quercetin has different and opposite effects on melanogenesis. This study examined the precise effects of quercetin on melanogenesis using cell-free assay systems and melanocytes. Quercetin inhibited the monophenolase and diphenolase activities of tyrosinase, and melanin synthesis in cell-free assay systems. Quercetin induced mild stimulation of the tyrosinase activity and dihydroxyphenylalaminechrome tautomerase (TRP-2) expression but only at low concentrations (<20 μm) in B16F10 melanoma cells. In contrast, the addition of 50 μm quercetin to the cells led to a significant decrease in the activity and synthesis of tyrosinase, as well as a decrease in the expression of tyrosinase-related protein-1 and TRP-2 proteins, regardless of the presence or absence of α-melanocyte stimulating hormone (α-MSH). Quercetin also reduced the intracellular cAMP and the phosphorylated protein kinase A levels in α-MSH-stimulated B16F10 cells. Moreover, quercetin (20 μm) diminished the expression and activity of tyrosinase, and melanin content in cultured normal human epidermal melanocytes. These effects were not related to its cytotoxic action. Although the in vivo effects of quercetin are still unclear, these results suggest that quercetin could play important roles in controlling melanogenesis.

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Evidence for antioxidant nutrients‐induced pigmentation in skin: Results of a clinical trial

Cited by 19 publications

References 11 publications

Can dietary intake influence perception of and measured appearance? A Systematic Review

Can dietary intake influence perception of and measured appearance? A Systematic Review

The Combined Effects of Extracts Containing Carotenoids and Vitamins E and C on Growth and Pigmentation of Cultured Human Melanocytes

Quercetin Inhibits α‐MSH‐stimulated Melanogenesis in B16F10 Melanoma Cells

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