Evidence for an Interaction Between Age at First Drink and Genetic Influences on DSM‐IV Alcohol Dependence Symptoms

Agrawal, Arpana; Sartor, Carolyn E.; Lynskey, Michael; Grant, Julia D.; Pergadia, Michele L.; Grucza, Richard A.; Bucholz, Kathleen K.; Nelson, Elliot C.; Madden, Pamela A. F.; Martin, Nicholas G.; Heath, Andrew C.

doi:10.1111/j.1530-0277.2009.01044.x

Cited by 73 publications

(58 citation statements)

References 61 publications

(69 reference statements)

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“…29 Earlier age of drinking onset is independently associated with increased risk of binge drinking 30 and alcohol dependence, 31 the latter observed in studies controlling for genetics. 32,33 Earlier drinking onset is also associated with onset of dependence at a younger age, 34 and among adults, injuring oneself or others after drinking in motor vehicle crashes and other ways. 35 A national survey of pediatricians and practitioners nearly a decade ago 36 indicated that most do not screen adolescent patients for alcohol use, often citing lack of confidence in their alcohol management skills.…”

Section: Resultsmentioning

confidence: 99%

Physician Advice to Adolescents About Drinking and Other Health Behaviors

et al. 2013

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WHAT'S KNOWN ON THIS SUBJECT: Evidence regarding effectively screening and counseling adolescents about unhealthy alcohol use is accumulating. Young adults aged 18 to 24, those most at risk for excess alcohol consumption, are often not asked or counseled by physicians about unhealthy alcohol use. WHAT THIS STUDY ADDS:In 2010 among US 10th graders (age 16), 36% drank, 28% binged, and 23% were drunk in the past month; although 82% saw a doctor, 54% were asked about drinking but only 17% were advised to reduce or stop drinking. abstract BACKGROUND: This report assessed the proportion of US 10th graders (average age, 16) who saw a physician in the past year and were asked and given advice about their drinking. We hypothesized that advice would vary by whether students were asked about drinking and their drinking, bingeing, and drunkenness frequency. METHODS:A nationally representative sample of 10th graders in 2010 (N = 2519) were asked their past 30-day frequency of drinking, bingeing, and intoxication and whether, during their last medical examination, their drinking was explored and they received advice about alcohol' s risks and reducing or stopping.

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Section: Resultsmentioning

confidence: 99%

Physician Advice to Adolescents About Drinking and Other Health Behaviors

et al. 2013

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“…Insights into the mechanisms that are responsible for negative spirals in development that could lead to problem behaviours are of great importance. It has been suggested that an early onset of substance use increases the odds of developing an addictive disorder (Agrawal et al 2009;Hingson et al 2006). In addition, having an anxiety or depressive disorder in adolescence increases the odds of having such a disorder in adulthood (Pine et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Prospective Relationships Between Sleep Problems and Substance Use, Internalizing and Externalizing Problems

Pieters

Burk

Vorst

et al. 2014

J Youth Adolescence

100

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While research has shown that sleep problems and substance use are reciprocally associated in adults, much less is known about this association in early adolescence. The main aim of the current longitudinal study was to explore bidirectional relationships between sleep problems, substance use, internalizing and externalizing problems in young adolescents. A prospective design was used incorporating two waves (approximately 1 year interval). A total of 555 young adolescents (290 females, M age = 13.96) participated in this study. All participants completed self-report measures in classrooms during regular school hours (questionnaires about sleep quality and sleep hygiene were used to measure sleep problems). The results indicated that sleep problems predicted changes in substance use, internalizing and externalizing problems over time, but problem behaviours did not predict changes in sleep problems, adjusted for gender, age and puberty. One exception was that alcohol use negatively predicted changes in sleep problems. This study suggests that sleep problems are important precursors of substance use, internalizing and externalizing problems in adolescence.

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“…Rather than being a fatal weakness, the replication of those relations using a variety of terms suggests a robust association, which has been found in cross-sectional surveys [4][5][6], in some [7][8][9][10][11] but not all [12] longitudinal studies and studies that control for genetics [13], such as studies of identical twins [14].…”

Section: The Usefulness Of 'Age At First Drink' As a Concept In Alcohmentioning

confidence: 99%

The usefulness of ‘age at first drink’ as a concept in alcohol research and prevention

2016

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Evidence for an Interaction Between Age at First Drink and Genetic Influences on DSM‐IV Alcohol Dependence Symptoms

Cited by 73 publications

References 61 publications

Physician Advice to Adolescents About Drinking and Other Health Behaviors

Physician Advice to Adolescents About Drinking and Other Health Behaviors

Prospective Relationships Between Sleep Problems and Substance Use, Internalizing and Externalizing Problems

The usefulness of ‘age at first drink’ as a concept in alcohol research and prevention

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