Evidence for an Important Role of Prostaglandins E2 and F2 in the Regulation of Zinc Transport in the Rat

Song, Min-Ae; Adham, Nabeel F.

doi:10.1093/jn/109.12.2152

Cited by 51 publications

(25 citation statements)

References 9 publications

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“…It is not known whether the heterozygous condition might have mild impairment of zinc absorption, but the defective allele is believed rare and seems unlikely to contribute significantly to widespread marginal zinc deficiency or to a disorder as common as ADHD. A potentially more common cause of poor absorption could be a defect in the production of prostaglandins E 2 and F 2 , which are necessary for zinc absorption (Song and Adham 1980). Yet another factor could be zinc-wasting metabolism, possibly precipitated by food additives or other ingested or environmental chemicals (Ward et al 1990).…”

Section: Zinc and Brain Functionmentioning

confidence: 99%

“…Zinc levels could just be markers for some other cause of ADHD, including poor general nutrition, rather than having a direct causative role. For example, they could be markers of essential fatty-acid deficiency or imbalance because series 2 prostaglandins, derived from polyunsaturated fatty acids, are believed to be necessary for zinc absorption (Song and Adham 1980). They could even be markers of general malnutrition Wesnes et al (2003) reported that a whole-grain cereal breakfast prevented the deterioration of schoolchild attention and memory over the morning that was found in nobreakfast and glucose-drink conditions.…”

Section: Cautions and Limitationsmentioning

confidence: 99%

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Zinc in Attention-Deficit/Hyperactivity Disorder

Arnold

DiSilvestro

2005

Journal of Child and Adolescent Psychopharmacology

128

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Objective:The aim of this study was to review the published evidence for a role of zinc nutrition in attentiondeficit/hyperactivity disorder (ADHD). Method:A computer literature search was supplemented by the authors' knowledge. Results:Numerous controlled studies report cross-sectional evidence of lower zinc tissue levels (serum, red cells, hair, urine, nails) in children who have ADHD, compared to normal controls and population norms. A few studies show correlations of zinc level with either clinical severity or a change thereof in response to stimulant or chemical challenge. Two placebo-controlled trials-one of zinc monotherapy, the other of zinc supplementation of methylphenidate-reported significant benefit. However, diagnostic procedures and sample representativeness were often not clear, and most such reports have come from countries and cultures with different diets and/or socioeconomic realities than are found in the United States (only one American sample in nine published reports). In particular, both positive clinical trials of zinc supplementation came from the Mid-East (Turkey and Iran), an area with suspected endemic zinc deficiency. The largest of these trials used zinc doses above the recommended upper tolerable limit and had a 2 in 3 dropout rate. Conclusion:It is not clear how well the accumulating evidence for a possible role of zinc in ADHD applies to middle-class American children. However, the evidence appears strong enough to warrant further controlled study in well-diagnosed samples representative of the socioeconomic spectrum. Hypothesistesting clinical trials are needed of this potential treatment that, if found effective, might become a relatively safe, cheap substitute for, or adjunct to, current treatments in some patients. At present, it should remain an investigational treatment.

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Section: Zinc and Brain Functionmentioning

confidence: 99%

Section: Cautions and Limitationsmentioning

confidence: 99%

Zinc in Attention-Deficit/Hyperactivity Disorder

Arnold

DiSilvestro

2005

Journal of Child and Adolescent Psychopharmacology

128

View full text Add to dashboard Cite

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“…Beside due to the Zn consumption, Zn absorption is also because of nabati oils content in PCF as resource of the unsaturated fatty acids used as prostaglandin PgE 2 syntesis precursor to increase Zn absorption (Hartati, 1998 and2008a). Song and Adham (1979) stressed that PgE 2 was able to increase Zn absorption up to 54 %. Hartati et al (2012a) has also suggested that Cu suplementation in form of organic compound Zn-Cu isoleusinate with hight biologis value was able to increase Cu absorption at post rumen and the increase up to 120 % compared to basal diets without suplementation…”

Section: Resultsmentioning

confidence: 99%

The Effects of Substitution of Corn Meal from the Concentrate of Plus-Complete Feed with Fermented Cocoa Pod on Growth of the Young Male Bali Cattle

Hartati¹,

Lestari²,

Saleh³

2017

J Applied Chem. Sci.

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Abstract:The study aimed to evaluate the effects of substitution of corn meal from concentrate of plus-complete feed (PCF) with fermented cocoa pod (FCP) on growth of the young male Bali Cattle. Fifteen young male Bali Cattles were randomly assigned into five groups for the substitutions of corn meal from the PCF by FCP treatments i.e 0, 25, 50, 75 and 100 % which each group was replicated by three subgroups. The pods were fermented with yeast Aspergillus niger that had been activated by combinations of sugar, urea, NPK fertilizers, and various levels of ZnSO 4 and Zn-Cu isoleusinate. The best FCP, that produced NH 3 and VFA in in vitro experiment, was used in the study. The results showed that substitutions of corn meal from the PCF by 100% FCP decreased signifikantly (P<0.01) Zn and Cu status, energy and N retention, and body weight gain of the young male Bali Cattles. However, the substitutions of corn meal with 0 %, 25% and 50% FCPs, those values did not decrease significant. Despite of corn meal substitutions of PCF by FCP did not decrease significantly plasma glucose and protein consumption, but substitution by FCP between of 0 % and 25 % did not decrease significantly protein consumption. In conclusion: the substitution of corn meal from the PCF by the FCP at the level up to 50% can be applied without disturbance the growth of the young male Bali Cattle.

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“…PGs have been shown to control zinc homeostasis [30,97]. Treatment of patients with anti-inflammatory dosages of aspirin for 13 weeks resulted in a gradual diminution of erythrocyte zinc levels (P. Dore-Duffy, unpublished observations).…”

Section: Prostaglandins and Msmentioning

confidence: 99%