Evidence for an Hla-Dr4-Associated Immune-Response Gene for Mycobacterium Tuberculosis

Ottenhoff, TomH.M; Tôrres, Pedro; Aguas, JoseTerencio De Las; Fernández, Ramón Fuentes; Eden, Willem van; Vries, RenéR.P. de; Stanford, J. L.

doi:10.1016/s0140-6736(86)90004-8

Cited by 94 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, genetic factors implicated in the response to mycobacterial vaccination have been identified in association studies within single racial groups. Nonresponse to vaccination was associated with not possessing the HLA-D3 histocompatibility antigen in 86 Caucasoid leprosy patients (p = 0.0005) [36], while HLA-DR4 was associated with high responsiveness in 74 healthy Caucasoid individuals (p = 0.005) [37]. Thus, in addition to previous contact with environmental mycobacteria, genetic factors are apparently another reason for variation in the response to mycobacterial vaccination [38, 39].…”

Section: Population Differences In the Response To Vaccinationmentioning

confidence: 99%

Genetic Variation in the Response to Vaccination

Kimman¹,

Vandebriel

Hoebee

2007

Public Health Genomics

View full text Add to dashboard Cite

Vaccines are the most powerful means to prevent and diminish the burden of infectious disease. However, there are limitations to their use: vaccines are not yet available for all infectious diseases (including human immunodeficiency virus and respiratory syncytial virus), they sometimes lack efficacy, the response to vaccination is limited by maternal antibodies in very young infants, and the response to vaccination is variable or may even be absent in some individuals. This review focuses on genetic factors that determine the variable response to vaccination. The highly polymorphic human leukocyte antigen system, which is involved in antigen presentation, has been researched most in this aspect, and clearly affects the response to vaccination. Other, but less polymorphic pathways involved are the Toll-like receptor pathway, which is involved in antigen recognition and stimulation of the immune system, and the cytokine immunoregulatory network. The heritability, or the proportion of total variance that is due to additive genetic factors, appears to be particularly large for vaccine-induced antibody responses in young infants compared with cell-mediated responses and antibody responses in older, immunologically more mature individuals. Both antibody and cell-mediated responses are not only affected by loci within, but also strongly by loci outside the human leukocyte antigen system. Because most genes that are important in influencing immune responses to vaccination are still unknown, clearly more work is required. A better understanding of the factors that determine an effective response to vaccination may lead to the identification of specific genes and pathways as targets for the development of novel more uniformly effective vaccines.

show abstract

Section: Population Differences In the Response To Vaccinationmentioning

confidence: 99%

Genetic Variation in the Response to Vaccination

Kimman¹,

Vandebriel

Hoebee

2007

Public Health Genomics

View full text Add to dashboard Cite

show abstract

“…Patients with rheumatoid arthritis respond relatively poorly to the common mycobacterial (group i) antigen, as do patients with leprosy or tuberculosis [3]. Skin-testing of 86 leprosy patients with four types of mycobacteria demonstrated that HLA-DR4 (a risk factor for rheumatoid arthritis) was associated with high responsiveness to antigens specific for M. tuberculosis [40]. Skin-testing of patients with rheumatoid arthritis also showed an increased responsiveness to tuberculin in those patients with the HLA-DR4 haplotype [3].…”

Section: Rheumatoid Arthritis and Tuberculosismentioning

confidence: 99%

The role of IgG glycoforms in the pathogenesis of rheumatoid arthritis

Rademacher

Parekh

Dwek

et al. 1988

Springer Semin Immunopathol

102

View full text Add to dashboard Cite

“…lectins), oligo-and polysaccharides and others [4], and the composition and amounts are influenced by the host tree [5] and the manufacturing process. Furthermore, the response to these antigens may differ from one individual to another and may be controlled by genetic factors, as shown, for instance, for common bacterial antigens [6].Recently, we showed that patients treated with an aqueous extract from mistletoe grown on apple trees (Helixor Mali) developed antibodies to mistletoe lectin-1 (ML-1) [7]. A proliferative response of lymphocytes from these patients to this extract was also detected in vitro, especially when the cytotoxic reaction of lectins was abolished by the addition of anti-ML-1 antibodies [8].…”

mentioning

confidence: 99%

Non-lectin component in a fermented extract from Viscum album L. grown on pines induces proliferation of lymphocytes from healthy and allergic individuals in vitro

Stein

Berg

1994

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Mistletoe preparations have been shown to express immunomodulatory properties. In order to evaluate the stimulatory potency of different mistletoe extracts, peripheral blood mononuclear cells (PBMC) from healthy and allergic/atopic individuals were exposed to aqueous or fermented extracts derived from Viscum album L. grown on apple trees (Mali-extracts) or on pines (Pini-extracts). None of them had received any mistletoe treatment. Iscador Pini was the only extract which strongly induced proliferation of PBMC in contrast to the other five preparations. On testing these extracts by Western blotting with anti-mistletoe lectin-1 (ML-1) antibody positive sera from mistletoe-treated patients, it became evident that Iscador Pini was almost devoid of lectins. The stimulatory potency of Iscador Pini for PBMC from three different groups was examined: PBMC from 35 normal controls (Group I), 23 patients with drug-induced adverse effects (Group II) and 16 individuals with allergic manifestations (Group III). Cells were exposed in 7-day cultures to the extract at concentrations between 1 and 10,000 micrograms/ml. PBMC from 63% of Group III individuals showed strong stimulation (SI varying from 6 to 97) in contrast to only 9% from Group I and 22% from Group II individuals. Anti-ML-1 antibodies were detected in 5% and anti-IP antibodies in 11% of subjects in the three groups. They were either of the IgA or IgM type but not of the IgG type. Our findings strongly imply that a non-lectin associated antigen from Iscador Pini is able to activate PBMC from healthy and allergic/atopic individuals, thereby demonstrating sensitization to probably highly conserved plant antigens.

show abstract

Evidence for an Hla-Dr4-Associated Immune-Response Gene for Mycobacterium Tuberculosis

Cited by 94 publications

References 27 publications

Genetic Variation in the Response to Vaccination

Genetic Variation in the Response to Vaccination

The role of IgG glycoforms in the pathogenesis of rheumatoid arthritis

Non-lectin component in a fermented extract from Viscum album L. grown on pines induces proliferation of lymphocytes from healthy and allergic individuals in vitro

Contact Info

Product

Resources

About