Evidence for an early free radical-mediated reperfusion injury in frostbite☆

Manson, Paul N.; Jesudass, Richard R.; Marzella, Louis; Bulkley, Gregory B.; Im, Michael J.; Narayan, Kailash

doi:10.1016/0891-5849(91)90015-u

Cited by 53 publications

(20 citation statements)

References 18 publications

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“…By peroxidation of the lipids in the endothelial membrane, the vessel wall integrity was destroyed. 37 All these can be the possible mechanisms underlying the tissue damage induced by the alternate cold and heat treatment. The current study has found freezing and heating have a synergistic effect in damaging tumor vasculature and result in better therapeutic outcome.…”

Section: Discussionmentioning

confidence: 99%

Study on Tumor Microvasculature Damage Induced by Alternate Cooling and Heating

et al. 2008

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Tumor vasculature damage induced by various thermal treatments has been studied in vivo via laser confocal microscopy. Murine mammary carcinoma 4T1 was implanted in the nude mice dorsal skin fold window chamber. The implanted tumor was treated by alternate cooling and heating. Results showed that the treatment was much more effective as compared with that of cooling or heating alone, especially in damaging the tumor vasculature. In general, tumor vascular response to thermal stimuli was heterogeneous. All the treatments of hyperthermia at 42 degrees C (for 1 h), alternate cooling at 1 degrees C and heating at 42 degrees C (for 1/2 h each) and that of -10 degrees C/42 degrees C (for 1/2 h each) enhanced liposome extravasation. Pre-cooling tumor at 1 degrees C preserved most of the vascular integrity but partially inhibited the effect of post-hyperthermia at 42 degrees C. On the other hand, cooling at -10 degrees C for 1/2 h before heating at 42 degrees C caused severe vessel damage. Histo-pathological analyses further confirmed the effect as rare tumor vessel recurrence and large necrotic tumor tissue areas shown on the 7th day after the treatment.

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Section: Discussionmentioning

confidence: 99%

Study on Tumor Microvasculature Damage Induced by Alternate Cooling and Heating

et al. 2008

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“…Needless to say, rewarming procedures could further aggravate the situation, given the potential for reperfusion injury. 24 However, the extent to which these could occur with the (improper) use of cold caps, the approach to effectively managing resultant injury, and whether cold cap use should then continue during subsequent chemotherapy cycles remain unanswered. In addition, the potential for developing permanent alopecia and scarring, and the resultant cosmetic disfigurement can be a huge concern.…”

Section: Discussionmentioning

confidence: 99%

Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia

Belum

Silva

Laloni

et al. 2016

Breast Cancer Res Treat

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INTRODUCTION The use of scalp cooling for the prevention of chemotherapy-induced alopecia (CIA) is increasing. Cold caps are placed onto the hair-bearing areas of the scalp for varying time periods before, during, and after cytotoxic chemotherapy cycles. Although not yet reported, improper application procedures could result in undesirable adverse events (AEs). At present, there are no evidence-based scalp cooling protocols, and there is no regulatory oversight of their use. OBJECTIVE To report the occurrence of cold thermal injury (frostbite) on the scalp, following the use of cold caps for the prevention of CIA. MATERIALS AND METHODS We identified four patients who developed cold thermal injuries on the scalp following the application of cold caps. Medical records were analyzed to retrieve the demographic, clinical, and histologic characteristics. RESULTS The cold thermal injuries in our patients were grade 1/2 in severity and improved with topical interventions, although mild persistent alopecia ensued in 3 patients. The true incidence of such injuries in this setting however, remains unknown. CONCLUSIONS Cold thermal cold injuries are likely an infrequent and preventable AE that may result from improper device application procedures during scalp cooling. Although these untoward events are usually mild to moderate in severity, the potential occurrence of long-term sequelae (e.g. permanent alopecia, scarring) are not known. Future prospective studies are needed to further elucidate the risk and standardized delivery methods, and patient/clinical education.

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“…Both the severity of cold and duration of exposure are important for determining the magnitude of tissue damage (Manson et al 1991). The rewarming of cold or frozen tissue exacerbates the cellular injury that has already occurred to some extent during cooling of the tissue due to volume expansion and ice formation.…”

Section: Classification Of Cold Injuriesmentioning

confidence: 99%

The role of free radicals in cold injuries

Bhaumik¹,

Srivastava

Selvamurthy

et al. 1995

Int J Biometeorol

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Cold injury is a tissue trauma produced by exposure to freezing temperatures and even brief exposure to a severely cold and windy environment. Rewarming of frozen tissue is associated with blood reperfusion and the simultaneous generation of free oxygen radicals. In this review is discussed the current understanding of the mechanism of action of free oxygen radicals as related to cold injury during rewarming. Decreased energy stores during ischaemia lead to the accumulation of adenine nucleotides and liberation of free fatty acids due to the breakdown of lipid membranes. On rewarming, free fatty acids are metabolized via cyclo-oxygenase and adenine nucleotides are metabolized via the xanthine oxidase pathway. These may be the source of free oxygen radicals. Leukocytes may also play a major role in the pathogenesis of cold injury. Oxygen radical scavengers, such as superoxide dismutase and catalase, may help to reduce the cold induced injury but their action is limited due to the inability readily to cross the plasma membrane. Lipid soluble antioxidants are likely to be more effective scavengers because of their presence in membranes where peroxidative reactions can be arrested.

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Evidence for an early free radical-mediated reperfusion injury in frostbite☆

Cited by 53 publications

References 18 publications

Study on Tumor Microvasculature Damage Induced by Alternate Cooling and Heating

Study on Tumor Microvasculature Damage Induced by Alternate Cooling and Heating

Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia

The role of free radicals in cold injuries

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