Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia

Geiss, Andrea; Rohleder, Nicolas; Anton, Fernand

doi:10.1016/j.psyneuen.2011.07.021

Cited by 57 publications

(54 citation statements)

References 74 publications

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“…However, our findings of serum IL-6 agrees with the report of Kim et al [26] who found no significant difference in serum IL-6 in FMS patients and control groups, on the other hand it differs from other studies revealing the high level of IL-6 in patients with FMS than in control group [27,28]. One of the study reported the higher level of IL-6 and TNF-a in the serum of FMS patients compared to control group [29].…”

Section: Discussionsupporting

confidence: 83%

Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

et al. 2012

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The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-a were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-a levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-a in patients with FMS, although TNF-a levels are found raised in patients with FMS.

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Section: Discussionsupporting

confidence: 83%

Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

et al. 2012

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“…Nevertheless, a limitation of our study may be that we measured cortisol and ACTH only once. This is because another study assessing the feedback sensitivity of the HPA axis in FM patients by conducting low-dose dexamethason suppression tests revealed normal feedback sensitivity in FM patients [20]. In any case, elevated circulating cortisol levels together with the increased systemic levels of NA denote a higher stress response in patients with FM, probably due to dysregulation of the inflammatory and stress feedback mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory/Stress Feedback Dysregulation in Women with Fibromyalgia

Bote

Garcı́a

Hinchado

et al. 2012

Neuroimmunomodulation

107

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Objective: Although one of the current hypotheses of the aetiology of fibromyalgia (FM) syndrome involves inflammatory and neuroendocrine disorders, its biophysiology still remains unclear. The purpose of the present investigation was to study the systemic inflammatory and stress responses, as well as the innate response mediated by monocytes and neutrophils in FM patients. Methods: Twenty-five women diagnosed with primary FM and 20 age-matched healthy women (control group) were enrolled in the study. Circulating ‘neuroendocrine-stress’ biomarkers (CRH, ACTH, cortisol, NA, eHsp72, serotonin and IGF-1) were evaluated by ELISA. Serum IL-8 and CRP concentrations were also determined by ELISA, and inflammatory cytokine release by monocytes [IL-1β, TNFα, IL-6, IL-10, IL-18, monocyte chemotactic protein-1 (MCP-1) and RANTES] was evaluated by the Luminex BioPlex system. The phagocytic process of neutrophils (chemotaxis, phagocytosis and microbicide capacity) was also evaluated. Results: FM patients showed an inflammatory state accompanied by an altered stress response. This is mainly manifested by high circulating levels of IL-8 and CRP (in 100% of the FM group), high circulating levels of cortisol, and increased systemic levels of NA and eHsp72. There is also increased release of inflammatory cytokines (IL-1β, TNFα, IL-6, IL-10, IL-18 and MCP-1) by monocytes, and enhanced activation of the functional capacity of neutrophils (chemotactic, phagocytic and fungicidal activities). Conclusion: An inflammatory/stress feedback dysregulation underlies FM. Whether dysregulation of the stress response is the cause of the inflammatory dysregulation or vice versa is also discussed.

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“…Salivary free cortisol output may be similar or higher in FMS patients compared to healthy subjects [333,340,341], while the cortisol awakening response (i.e., the rise in cortisol concentrations in the first hour after awakening) can be normal or diminished [340,342,343]. Total and free cortisol concentrations may be dissociated in FMS patients.…”

Section: Stress the Hpa Axis And The Autonomic Nervous Systemmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

225

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia

Cited by 57 publications

References 74 publications

Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

Inflammatory/Stress Feedback Dysregulation in Women with Fibromyalgia

Fibromyalgia: A Critical and Comprehensive Review

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