Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study

Abstract

ABSTRACT. Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/ T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. Although ACE has been reported to be one of the main polymorphisms associated with hypertension, we found no association with ACE's specific genotypes. However, a possible 2167 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 9 (4): 2166-2175 (2010) Gene polymorphisms linked to hypertension in Brazil association with Hp1-1 and MnSOD Val/Ala genotypes suggests that, at least for the Brazilian population, polymorphisms related to oxidative stress should be more deeply investigated.

Genetic polymorphisms influence runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi oil (Caryocar brasiliense Camb.): a before-after study

“…The ACE D allele has been also associated with increased ACE activity [3,133], and an increase in plasma ACE activity may increase blood pressure through increased production of angiotensin II [123]; as a result, the ACE I/D polymorphism has been associated with hypertension [10,81,99,123]. However, this association is controversial and no correlation has been found in other studies [5,32,91,93,146]. In contrast, other studies suggest that ethnicity affects both ACE I/D allele frequency and the relationship between ACE I/D genotype and serum ACE concentration [47].…”

Quantitative Serum Proteomic Analysis of Essential Hypertension Using iTRAQ Technique

“…There was significant recent progress in studies on genomics and metabolomics, which revealed that the onset of EH was closely related to vascular endothelial and kidney dysfunction. However, the vital substances involved in these complicated pathological cases were not clearly demonstrated [ 14 – 16 ]. It is urgent to reveal which or what kind of substances had effects on raising BP.…”

“…These rats were extremely sensitive to ingested salt. Their research showed the deficiency of KNG or kinin production would directly led to the accumulation of sodium in the body followed by hypertension [ 16 ]. In our study, the expression of KNG1 was decreased in EH patients according to proteomics in discovery section and immunoassay in the verification phase.…”

Involvement of haptoglobin in prevention of oxidative stress cause by hemoglobin in preeclampsia

“…In a previous study on hypertension, an association between Hp 2-2 phenotype and higher occurrence of RH was found [19]. A second recent Brazilian study showed that individuals of the Hp 1-1 phenotype had an approximately 3 fold increase in essential hypertension [20]. These conflicting reports may be due to the cross sectional nature of the studies and indicates that additional prospective studies need to be carried out.…”