Evidence for Amelioration of Steroid-Mediated Immunosuppression by Ascorbic Acid

Pardue, S. L.; Thaxton, J. P.

doi:10.3382/ps.0631262

Cited by 57 publications

(17 citation statements)

References 29 publications

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“…Although poultry are able to synthesize vitamin C and they do not need an exogenous source of vitamin C, it has been documented that particular environmental stressors can alter ascorbic acid utilization or synthesis in avian species (Pardue and Thaxton, 1984). It has been also reported that ascorbic acid synthesis is inadequate under stress conditions such as low or high environmental temperatures, humidity, high productive rate, and parasite infestation (McDowell, 1989;Cheng et al, 1990).…”

Section: Introductionmentioning

confidence: 98%

Effects of Dietary Chromium Picolinate and Ascorbic Acid Supplementation on Egg Production, Egg Quality and Some Serum Metabolites of Laying Hens Reared under a Low Ambient Temperature (6 °C)

Şahin

Onderci

Şahin

et al. 2002

Archiv für Tierernaehrung

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This experiment was conducted to evaluate the effects of chromium (chromium picolinate, Cr Pic) and vitamin C (L-ascorbic acid) supplementation on egg production and egg quality in laying hens (Hy-Line) kept at 18 degrees C (at thermo-neutral zone) or 6 degrees C (cold stress) in temperature-controlled rooms. One hundred and fifty laying hens (32 week-old) were divided into 5 groups, 30 hens per group. The laying hens kept at 6 degrees C temperature were fed either a basal diet (low temperature-basal diet, LTB group) or the basal diet supplemented with either 400 micrograms of Cr per kg diet (Cr group), 250 mg of L-ascorbic acid per kg diet (Vit C group) or 400 micrograms of Cr plus 250 mg of L-ascorbic acid per kg diet (Vit C + Cr group) while hens kept at 18 degrees C fed a basal diet (thermo-neutral-basal diet, TNB group). Performance and egg quality were significantly reduced in LTB group compared with TNB group. Supplemental chromium and vitamin C significantly increased live weight change, egg production, and improved feed efficiency in cold-stressed hens compared with group fed the basal diet at 6 degrees C brought up to the values of the group reared under thermoneutral conditions (18 degrees C). Egg production and egg weight were also greater in each supplemental group compared with the LTB group. Separately or as a combination, supplemental chromium and vitamin C increased serum insulin but decreased corticosterone, glucose and cholesterol concentrations. Results of the present study show that supplementing vitamin C and chromium, particularly as a combination, improved the performance of cold-stressed hens. Such a combination of supplement can offer a potential protective management practice in preventing cold stress-related losses in performance of laying hens.

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Section: Introductionmentioning

confidence: 98%

Effects of Dietary Chromium Picolinate and Ascorbic Acid Supplementation on Egg Production, Egg Quality and Some Serum Metabolites of Laying Hens Reared under a Low Ambient Temperature (6 °C)

Şahin

Onderci

Şahin

et al. 2002

Archiv für Tierernaehrung

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“…Corticosterone concentration in the heat and no AA treatment was found to be significantly higher than in the other three treatments if the level of significance was tested at the .10 level of probability. Pardue and Thaxton (1984) reported that AA ameliorated the immune suppression in broiler chicks. However, these authors used only two dietary levels of AA (0 and 1000 ppm) and exogenous cortisol injections.…”

Section: Corticosterone Assaymentioning

confidence: 99%

Performance and Humoral Immune Response in Heat-Stressed Broilers Fed an Ascorbic Acid Supplemented Diet

Tuekam

Miles

Butcher

1994

Journal of Applied Animal Research

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“…Vitamin C supplementation was expected to decrease corticosterone concentration as vitamin C inhibits glucocorticoid synthesis (Pardue et al, 1985). Vitamin C is also known to increase the use of corticosteroids released during stress (Pardue and Thaxton, 1984), thus playing an important role in responding to stress. Vitamin C and chromium have been shown to alleviate the negative eects of stress such as cold stress-related depression in poultry performance (McDowell, 1989; Sahin et al, 2001a).…”

Section: Discussionmentioning

confidence: 99%

Optimal dietary concentrations of vitamin C and chromium for alleviating the effect of low ambient temperature on serum insulin, corticosterone, and some blood metabolites in laying hens

Şahin

Onderci

2002

J Trace Elements Exper Med

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This experiment was conducted to evaluate the effects of vitamin C (L-ascorbic acid) and chromium (chromium picolinate, CrPic) on serum insulin, corticosterone, and some metabolites in laying hens (Hy-Line) reared under a low ambient temperature (6.2°C). One hundred eighty laying hens (32 weeks old) were divided into six groups, with 30 hens per group. The experiment was designed in a 2´3 factorial arrangement using two levels of vitamin C (125 and 250 mg/kg of diet) and three levels of CrPic (200, 400, or 800 lg/kg of diet). The highest values for insulin, total protein, and albumin (P = 0.001) and the lowest values for corticosterone, glucose, triglyceride, and cholesterol (P = 0.001) were obtained when 250 mg of vitamin C was included with either 400 or 800 lg Cr per kg of diet. Interaction between vitamin C and chromium was detected for only insulin (P = 0.03). Serum activities of SGOT and SGPT were not in¯uenced by dietary vitamin C or chromium (P > 0.45); however, serum activity of AP increased (P = 0.001). Increasing both dietary vitamin C and chromium caused an increase in serum concentrations of Ca, P, and K (P = 0.001) but a decrease in serum concentrations of Na (P = 0.001). The results of the present study suggest that dietary supplements of vitamin C and chromium alter serum hormone and metabolite status of laying hens and that supplementing a combination of vitamin C (250 mg/kg of diet) and chromium (400 or 800 lg Cr/kg of diet) can positively inuence the performance of laying hens reared under low ambient temperature.

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Evidence for Amelioration of Steroid-Mediated Immunosuppression by Ascorbic Acid

Cited by 57 publications

References 29 publications

Effects of Dietary Chromium Picolinate and Ascorbic Acid Supplementation on Egg Production, Egg Quality and Some Serum Metabolites of Laying Hens Reared under a Low Ambient Temperature (6 °C)

Effects of Dietary Chromium Picolinate and Ascorbic Acid Supplementation on Egg Production, Egg Quality and Some Serum Metabolites of Laying Hens Reared under a Low Ambient Temperature (6 °C)

Performance and Humoral Immune Response in Heat-Stressed Broilers Fed an Ascorbic Acid Supplemented Diet

Optimal dietary concentrations of vitamin C and chromium for alleviating the effect of low ambient temperature on serum insulin, corticosterone, and some blood metabolites in laying hens

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