Evidence for alternative exhaled elimination profiles of disinfection by‐products and potential markers of airway responses to swimming in a chlorinated pool environment

Heaney, Liam M.; Kang, Shuo; Turner, Matthew A.; Lindley, Martin R.; Thomas, C. L. Paul

doi:10.1111/ina.12630

Cited by 4 publications

(2 citation statements)

References 48 publications

(100 reference statements)

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“…Exhaled breath VOCs were collected using a previously described portable breath collection unit [17]. Two litres of breath were sampled and VOCs retained onto an adsorbent bed packed into thermal desorption tubes (Markes International, Llantrisant, UK).…”

Section: Exhaled Breath Sampling and Analysismentioning

confidence: 99%

“…Samples were analysed for VOC content by thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) using a Unity TD Unit (Markes International, Llantrisant, UK) coupled to Varian 3800 GC and Varian 4000 ion trap MS instrument (now Agilent Technologies, Stockport, UK). Detailed information on the analytical protocol can be found elsewhere [17,18].…”

Section: Exhaled Breath Sampling and Analysismentioning

confidence: 99%

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The Impact of a Graded Maximal Exercise Protocol on Exhaled Volatile Organic Compounds: A Pilot Study

et al. 2022

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Exhaled volatile organic compounds (VOCs) are of interest due to their minimally invasive sampling procedure. Previous studies have investigated the impact of exercise, with evidence suggesting that breath VOCs reflect exercise-induced metabolic activity. However, these studies have yet to investigate the impact of maximal exercise to exhaustion on breath VOCs, which was the main aim of this study. Two-litre breath samples were collected onto thermal desorption tubes using a portable breath collection unit. Samples were collected pre-exercise, and at 10 and 60 min following a maximal exercise test (VO2MAX). Breath VOCs were analysed by thermal desorption-gas chromatography-mass spectrometry using a non-targeted approach. Data showed a tendency for reduced isoprene in samples at 10 min post-exercise, with a return to baseline by 60 min. However, inter-individual variation meant differences between baseline and 10 min could not be confirmed, although the 10 and 60 min timepoints were different (p = 0.041). In addition, baseline samples showed a tendency for both acetone and isoprene to be reduced in those with higher absolute VO2MAX scores (mL(O2)/min), although with restricted statistical power. Baseline samples could not differentiate between relative VO2MAX scores (mL(O2)/kg/min). In conclusion, these data support that isoprene levels are dynamic in response to exercise.

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Section: Exhaled Breath Sampling and Analysismentioning

confidence: 99%

Section: Exhaled Breath Sampling and Analysismentioning

confidence: 99%

The Impact of a Graded Maximal Exercise Protocol on Exhaled Volatile Organic Compounds: A Pilot Study

et al. 2022

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Hybridization of carboxymethyl chitosan with bimetallic MOFs to construct renewable metal ion “warehouses” with rapid sterilization and long-term antibacterial effects

Zhang²,

Zhang³

et al. 2023

Carbohydrate Polymers

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A literature survey of all volatiles from healthy human breath and bodily fluids: the human volatilome

et al. 2021

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This paper comprises an updated version of the 2014 review which reported 1846 volatile organic compounds (VOCs) identified from healthy humans. In total over 900 additional VOCs have been reported since the 2014 review and the VOCs from semen have been added. The numbers of VOCs found in breath and the other bodily fluids are: blood 379, breath 1488, faeces 443, milk 290, saliva 549, semen 196, skin 623 and urine 444. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been included in a single table with the source reference(s) for each VOC, an update on our 2014 paper. VOCs have also been grouped into tables according to their chemical class or functionality to permit easy comparison. Careful use of the database is needed, as a number of the identified VOCs only have level 2—putative assignment, and only a small fraction of the reported VOCs have been validated by standards. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces and breath. However, the lack of compounds from matrices such a semen and milk compared to breath for example could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from milk and semen compared to a large number for breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. by collecting skin sebum (with dissolved VOCs and semi VOCs) onto glass beads or cotton pads and then heating to a high temperature to desorb VOCs. All compounds have been included as reported (unless there was a clear discrepancy between name and chemical structure), but there may be some mistaken assignations arising from the original publications, particularly for isomers. It is the authors’ intention that this work will not only be a useful database of VOCs listed in the literature but will stimulate further study of VOCs from healthy individuals; for example more work is required to confirm the identification of these VOCs adhering to the principles outlined in the metabolomics standards initiative. Establishing a list of volatiles emanating from healthy individuals and increased understanding of VOC metabolic pathways is an important step for differentiating between diseases using VOCs.

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Evidence for alternative exhaled elimination profiles of disinfection by‐products and potential markers of airway responses to swimming in a chlorinated pool environment

Cited by 4 publications

References 48 publications

The Impact of a Graded Maximal Exercise Protocol on Exhaled Volatile Organic Compounds: A Pilot Study

The Impact of a Graded Maximal Exercise Protocol on Exhaled Volatile Organic Compounds: A Pilot Study

Hybridization of carboxymethyl chitosan with bimetallic MOFs to construct renewable metal ion “warehouses” with rapid sterilization and long-term antibacterial effects

A literature survey of all volatiles from healthy human breath and bodily fluids: the human volatilome

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