Evidence for adrenergic neurons in a memory access pathway

Cohen, Ricki L.; Hamburg, Martin D.

doi:10.1016/0091-3057(75)90066-0

Cited by 19 publications

(6 citation statements)

References 17 publications

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“…It is well established that ␤-adrenergic activation is involved in the consolidation and retrieval of contextual fear memories (Cohen and Hamburg 1975) and spatial memories that were driven by emotional and nonemotional processes (Sara 1985;Decker et al 1990;Przybyslawski et al 1999;Cahill et al 2000;Liao et al 2002). Furthermore, activation of dopaminergic D1 receptors has been reported to be required for memory consolidation in a spatial reference memory task (Liao et al 2002), when dopamine function was blocked within the medial prefrontal cortex (PFC) (Levin 1988;Seamans et al 1998;Kozlov et al 2001; DeOliveira and Nakamura-Palacios 2003), the nucleus accumbens (Ferretti et al 2005), or the septum (Simon et al 1986).…”

Section: The Role Of ␤-Adrenergic and Dopaminergic Activation In Memomentioning

confidence: 99%

Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval

Korz

Frey²

2007

Learn. Mem.

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Recently it was shown that holeboard training can reinforce, i.e., transform early-LTP into late-LTP in the dentate gyrus during the initial formation of a long-term spatial reference memory in rats. The consolidation of LTP as well as of the reference memory was dependent on protein synthesis. We have now investigated the transmitter systems involved in this reinforcement and found that LTP-consolidation and memory retrieval were dependent on ␤-adrenergic, dopaminergic, and mineralocorticoid receptor (MR) activation, whereas glucocorticoid receptors (GRs) were not involved. Blockade of the ␤-adrenergic signaling pathway significantly increased the number of reference memory errors compared with MR and dopamine receptor inhibition. In addition, ␤-adrenergic blockade impaired the working memory. Therefore, we suggest that ␤-adrenergic receptor activation is the main signaling system required for the retrieval of spatial memory. In addition, other modulatory interactions such as dopaminergic as well as MR systems are involved. This result points to specific roles of different modulatory systems during the retrieval of specific components of spatial memory. The data provide evidence for similar integrative interactions between different signaling systems during cellular memory processes.

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Section: The Role Of ␤-Adrenergic and Dopaminergic Activation In Memomentioning

confidence: 99%

Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval

Korz

Frey²

2007

Learn. Mem.

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“…In particular, scopolamine impairs the retention of a passive avoidance response when administered before the acquisition trial (Bohdanecky and Jarvik 1967). The same behavioural deficit is produced by inhibiting noradrenergic transmission with the beta blocker propranolol (Cohen and Hamburg 1975). We now report that BC-PS can antagonize scopolamine but not propranolol-induced anterograde amnesia in rats in a stepthrough type of passive avoidance test.…”

mentioning

confidence: 67%

Reversal of scopolamine-induced amnesia by phosphatidylserine in rats

1986

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Scopolamine (2 mg/kg IP) and propranolol (55 mg/kg IP), given before a single learning trial, reduce retention of a passive avoidance response in rats. Phosphatidylserine, 30-60 mg/kg IP, antagonizes the amnesic effect of scopolamine but not that of propranolol. The retention of the passive avoidance response is not affected by phosphatidylserine given alone. The results indicate that this phospholipid selectively counteracts the action of scopolamine on passive avoidance acquisition, probably via a cholinergic mechanism.

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“…In a passive-avoidance task, both DDC (Hamburg and Cohen, 1973) and propranolol (Cohen and Hamburg, 1975) disrupted retention test performance regardless of the training-retest interval. These results stand in contrast to those observed following administration of ACh agonists using an identical paradigm (Hamburg and Fulton, 1972).…”

Section: Antiadrenergic Agentsmentioning

confidence: 90%

“…The memory disruptive property of posttrial DCI has been replicated by Merlo and Izquierdo (1971). Interestingly, propranolol, also a f3-adrenergic blocking agent, has been reported to disrupt memory for a passive-avoidance response (Cohen and Hamburg, 1975), but produced memory facilitation when administered shortly following training in a shuttle-box avoidance task (Merlo and Izquierdo, 1971). The procedure of administering reserpine together with CA and serotonin precursors shortly following training has more recently been used in a study using an inhibitory (passive) avoidance task (Rake, 1973).…”

Section: Antiadrenergic Agentsmentioning

confidence: 99%