Evidence for activation of Amh gene expression by steroidogenic factor 1

Takada, Shuji; Wada, Toyoji; Kaneda, Ruri; Choi, Young Lim; Yamashita, Yuichi; Mano, Hiroyuki

doi:10.1016/j.mod.2006.04.004

Cited by 13 publications

(6 citation statements)

References 35 publications

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“…Direct regulation of AMH production via Clock gene expression is also considered possible given the fact that Steroidogenic Factor 1 (SF-1) binding sites (a downstream CCG gene) have been identified within the 5' region of the amh gene in both mammals [90] and fish [91]. SF-1 ( nr5a1 ) is the closest nuclear orphan receptor family member to the LRH-1 gene ( nr5a2 ) [92].…”

Section: Resultsmentioning

confidence: 99%

Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling

et al. 2010

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BackgroundClock family genes encode transcription factors that regulate clock-controlled genes and thus regulate many physiological mechanisms/processes in a circadian fashion. Clock1 duplicates and copies of Clock3 and NPAS2-like genes were partially characterized (genomic sequencing) and mapped using family-based indels/SNPs in rainbow trout (RT)(Oncorhynchus mykiss), Arctic charr (AC)(Salvelinus alpinus), and Atlantic salmon (AS)(Salmo salar) mapping panels.ResultsClock1 duplicates mapped to linkage groups RT-8/-24, AC-16/-13 and AS-2/-18. Clock3/NPAS2-like genes mapped to RT-9/-20, AC-20/-43, and AS-5. Most of these linkage group regions containing the Clock gene duplicates were derived from the most recent 4R whole genome duplication event specific to the salmonids. These linkage groups contain quantitative trait loci (QTL) for life history and growth traits (i.e., reproduction and cell cycling). Comparative synteny analyses with other model teleost species reveal a high degree of conservation for genes in these chromosomal regions suggesting that functionally related or co-regulated genes are clustered in syntenic blocks. For example, anti-müllerian hormone (amh), regulating sexual maturation, and ornithine decarboxylase antizymes (oaz1 and oaz2), regulating cell cycling, are contained within these syntenic blocks.ConclusionsSynteny analyses indicate that regions homologous to major life-history QTL regions in salmonids contain many candidate genes that are likely to influence reproduction and cell cycling. The order of these genes is highly conserved across the vertebrate species examined, and as such, these genes may make up a functional cluster of genes that are likely co-regulated. CLOCK, as a transcription factor, is found within this block and therefore has the potential to cis-regulate the processes influenced by these genes. Additionally, clock-controlled genes (CCGs) are located in other life-history QTL regions within salmonids suggesting that at least in part, trans-regulation of these QTL regions may also occur via Clock expression.

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Section: Resultsmentioning

confidence: 99%

Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling

et al. 2010

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“…This is prior to the onset of histological differentiation and prior to the onset of SOX9 expression in males (day 6.0; stage 29; Oreal et al, 1998). Recent evidence suggests that SF1 may be at least partly responsible to activating AMH gene expression in avian embryos (Takada et al, 2006). While AMH expression appears similar in both sexes at the very early stages, it becomes stronger in male chicken embryos by stage 28 (day 5.5-6) ( Fig.…”

Section: When Are Sex-determining Genes Operating?mentioning

confidence: 88%

Avian sex determination: what, when and where?

Smith

Roeszler

Hudson

et al. 2007

Cytogenet Genome Res

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Sex is determined genetically in all birds, but the underlying mechanism remains unknown. All species have a ZZ/ZW sex chromosome system characterised by female (ZW) heterogamety, but the chromosomes themselves can be heteromorphic (in most birds) or homomorphic (in the flightless ratites). Sex in birds might be determined by the dosage of a Z-linked gene (two in males, one in females) or by a dominant ovary-determining gene carried on the W sex chromosome, or both. Sex chromosome aneuploidy has not been conclusively documented in birds to differentiate between these possibilities. By definition, the sex chromosomes of birds must carry one or more sex-determining genes. In this review of avian sex determination, we ask what, when and where? What is the nature of the avian sex determinant? When should it be expressed in the developing embryo, and where is it expressed? The last two questions arise due to evidence suggesting that sex-determining genes in birds might be operating prior to overt sexual differentiation of the gonads into testes or ovaries, and in tissues other than the urogenital system.

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“…Ad4bp/sf-1 was initially identified as a key regulator for steroid hormone biosynthesis [Bakke et al, 2001]. It is involved in the differentiation/development of testis and ovary by regulating the transcription of amh in males and cyp19a1 in females [Yoshiura et al, 2003;Takada et al, 2006;Wang et al, 2007]. In catfish its expression was also seen in indifferent gonads during early development.…”

Section: Discussionmentioning

confidence: 99%

Dimorphic Expression of Various Transcription Factor and Steroidogenic Enzyme Genes during Gonadal Ontogeny in the Air-Breathing Catfish, <i>Clarias gariepinus</i>

Kavarthapu

Senthilkumaran

Sudhakumari

et al. 2011

Sex Dev

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In the present study the expression of 13 genes known to be involved in sex differentiation and steroidogenesis in catfish was analyzed during gonadal ontogeny by quantitative real-time RT-PCR. Dmrt1 and sox9a showed exclusive expression in male gonads while ovarian aromatase (cyp19a1) and foxl2 were abundant in differentiating female gonads. Most of the genes related to steroidogenesis were expressed only after gonadal differentiation. However, genes coding for 3β-hydroxysteroid dehydrogenase (3β-hsd), 17α-hydroxylase/C17–20 lyase type 1 (cyp17) and steroidogenic acute regulatory protein (star) were barely detectable during gonadal differentiation. Ovarian aromatase, cyp19a1, which is responsible for estradiol-17β biosynthesis in females, was expressed very early in the undifferentiated gonads of catfish, around 30–40 days post hatch (dph). The steroidogenic enzyme, 11β-hydroxylase (cyp11b1) required for the production of 11-ketotestosterone (11-KT) was expressed only after differentiation of testis. These results suggest that estradiol-17β has a critical role in ovarian differentiation, while the role of 11-KT in testicular differentiation is doubtful. In conclusion, dimorphic expression of dmrt1 and sox9a in gonads during early development is required for testicular differentiation, and sex-specific expression of cyp19a1 and foxl2 in females plays a critical role in ovarian development. Our study reveals that the critical period of gonadal differentiation in catfish starts around 30–40 dph when sex-specific genes showed differential expression.

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Evidence for activation of Amh gene expression by steroidogenic factor 1

Cited by 13 publications

References 35 publications

Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling

Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling

Avian sex determination: what, when and where?

Dimorphic Expression of Various Transcription Factor and Steroidogenic Enzyme Genes during Gonadal Ontogeny in the Air-Breathing Catfish, <i>Clarias gariepinus</i>

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