Evidence for a Similar Cytokine Pattern Expressed in Allergic Contact and Atopic Dermatitis

Interaction of keratinocytes with infiltrating lymphocytes in allergic eczematous skin diseases

“…Some studies point to the fact that not only in atopic dermatitis but also in ACD there is a switch from a more Th2-like initial expression pattern to a more Th1-like pattern in later phases (M.M. Neis, B. Peters, A. Dreuw et al, unpublished data) [16]. The kinetics and quantity of mediator expression, however, are different in ACD and atopic dermatitis.…”

The Sequence of Stimuli Determines the Amount of IL-12 Produced by Human Monocytes

“…Evidence is accumulating for a compartmentalization of type 2-like cytokine production in acute eczematous reactions irrespective of the underlying skin disease or the nature of the allergen (i.e. environmental protein or haptenized protein) provokating cutaneous eczema in humans [9]. As CD40L+ T cells are present in early eczematous skin lesions shown by immunohistochemical staining we provide evidence for a possible mechanism responsible for a Th2-like cytokine milieu in early eczematous skin lesions.…”