Evidence for a role of heme oxygenase-1 in the control of cardiac function in zebrafish (<i>Danio rerio</i>) larvae exposed to hypoxia

Tzaneva, Velislava; Perry, Steve F.

doi:10.1242/jeb.136853

Cited by 16 publications

(18 citation statements)

References 76 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HO‐1 increased expression is associated with cardiac protection . In the developing zebrafish heart, the enzyme is located on presumptive pacemaker cells, and this suggested a role on setting heart rate . Recently, HO‐2 was detected in the heart of the blunt snout bream M. amblycephala , where the enzyme is present in 2 isoforms, HO‐2a and HO‐2b, generated by gene duplication.…”

Section: Co As a Cardiac Gasotransmittermentioning

confidence: 96%

“…In larval and adult rainbow trout, in vivo exposure to CO is accompanied by a positive chronotropic response . A similar response was found in both larval trout and HO‐1‐expressing zebrafish larvae exposed to hypoxia . As in mammals, this effect has been correlated with a modulation of the sympathetic nervous activity by the HO‐1/CO system (for references, see ref.…”

Section: Co As a Cardiac Gasotransmittermentioning

confidence: 97%

“…Recent studies have extended to poikilotherms the role of CO as an endogenous physiological regulator. Teleost fish express both HO‐1 and HO‐2 and thus are able to endogenously generate CO. CO‐forming enzymes were detected in cyprinid species, such as C. auratus , Cyprinus carpio , Danio rerio and Megalobrama amblycephala , and in the European sea bream Dicentrarchus labrax L . Contrary to teleost, few data document the presence of CO‐forming enzymes in amphibians…”

Section: Comentioning

confidence: 99%

“…As in mammals, this effect has been correlated with a modulation of the sympathetic nervous activity by the HO‐1/CO system (for references, see ref. ). In contrast, zebrafish larvae lacking HO‐1 exhibited a significant higher heart rate under normoxia, but not hypoxia.…”

Section: Co As a Cardiac Gasotransmittermentioning

confidence: 99%

“…In contrast, zebrafish larvae lacking HO‐1 exhibited a significant higher heart rate under normoxia, but not hypoxia. This effect, rescued by exogenous CORM‐derived CO, was insensitive to adrenaline, suggesting that under normoxia the cardiac effects of endogenous CO are independent from the autonomic regulation . The finding that in zebrafish larvae gasotransmitters are involved in cardiac function modulation also in relation to oxygen availability should be regarded with interest for exploring mechanisms able to improve mammalian myocardium resistance to oxygen deprivation (ie during ischaemia).…”

Section: Co As a Cardiac Gasotransmittermentioning

confidence: 99%

See 4 more Smart Citations

NO, CO and H₂S: What about gasotransmitters in fish and amphibian heart?

et al. 2018

View full text Add to dashboard Cite

The gasotransmitters nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H S), long considered only toxicant, are produced in vivo during the catabolism of common biological molecules and are crucial for a large variety of physiological processes. Mounting evidence is emerging that in poikilotherm vertebrates, as in mammals, they modulate the basal performance of the heart and the response to stress challenges. In this review, we will focus on teleost fish and amphibians to highlight the evolutionary importance in vertebrates of the cardiac control elicited by NO, CO and H S, and the conservation of the intracellular cascades they activate. Although many gaps are still present due to discontinuous information, we will use examples obtained by studies from our and other laboratories to illustrate the complexity of the mechanisms that, by involving gasotransmitters, allow beat-to-beat, short-, medium- and long-term cardiac homoeostasis. By presenting the latest data, we will also provide a framework in which the peculiar morpho-functional arrangement of the teleost and amphibian heart can be considered as a reference tool to decipher cardiac regulatory networks which are difficult to explore using more conventional vertebrates, such as mammals.

show abstract

Section: Co As a Cardiac Gasotransmittermentioning

confidence: 96%

Section: Co As a Cardiac Gasotransmittermentioning

confidence: 97%