Evidence for a Relationship between VEGF and BMI Independent of Insulin Sensitivity by Glucose Clamp Procedure in a Homogenous Group Healthy Young Men

Loebig, Michaela; Klement, Johanna; Schmoller, André; Betz, Simone; Heuck, Nicole; Schweiger, Ulrich; Peters, Achim; Schultes, Bernd; Oltmanns, Kerstin M.

doi:10.1371/journal.pone.0012610

Cited by 81 publications

(71 citation statements)

References 33 publications

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“…Adipose tissue is considered to be an endocrine organ and releases hormones, enzymes and cytokines, including VEGF and IL-6 [14,15]. In 2010, Loebig et al observed a positive correlation between BMI and serum VEGF level [15]. A similar result was obtained by Doupis et al Their research showed increased VEGF level in the serum of non-obese patients with diabetes, and in obese patients with diabetes.…”

Section: Discussionmentioning

confidence: 69%

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VEGF-A i PDGF-BB — czynniki angiogenne a stopień zaawansowania zespołu stopy cukrzycowej

Drela¹,

Kulwas²,

Jundziłł³

et al. 2014

Endokrynologia Polska

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Introduction: In patients with diabetic foot syndrome (DFS), an inadequate angiogenic response is observed. The aim of this study was to evaluate the concentrations of VEGF-A, PDGF-BB, sVEGF-R2 and sVEGF-R1 in patients with diabetes-complicated diabetic foot syndrome and analyse them using selected clinical data. Material and methods: Forty seven diabetic patients, 25 women mean age 63 and 20 men mean age 60.5, with diabetic foot syndrome (DFS) were enrolled in the experimental group. To evaluate angiogenesis factors depending on Wagner grade, the subjects were divided into three subgroups: I -patients with 0 Wagner grade (n = 14); II -patients with 1,2,3 Wagner grades (n = 15); and III -patients with 4,5 Wagner grades (n = 18). The control group consisted of 20 healthy volunteers. The material for research was blood. In this study, a strong positive correlation between VEGF-A and PDGF-BB was observed (R = 0.66; p = 0.000001). Conclusions: Our study revealed that proangiogenic factor levels were increased in DFS. This is associated with lower limb ischaemia and hypoxic conditions. The stage of diabetic foot syndrome advancement influenced VEGF-A and PDGF-BB concentrations.

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Section: Discussionmentioning

confidence: 69%

“…most patients were overweight or obese. Adipose tissue is considered to be an endocrine organ and releases hormones, enzymes and cytokines, including VEGF and IL-6 [14,15]. In 2010, Loebig et al observed a positive correlation between BMI and serum VEGF level [15].…”

Section: Discussionmentioning

confidence: 99%

VEGF-A i PDGF-BB — czynniki angiogenne a stopień zaawansowania zespołu stopy cukrzycowej

Drela¹,

Kulwas²,

Jundziłł³

et al. 2014

Endokrynologia Polska

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“…In their study, Wada et al (2011) obtained similar findings to those in the SAPHIR study. Likewise, Loebig et al (2010), when examining the phenomenon of insulin resistance, observed a positive correlation between VEGF-A levels and BMI values, but only considered the parameters of hormonal balance without taking account of the presence of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia

Wieczór

Gadomska

et al. 2016

J. Zhejiang Univ. Sci. B

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Objective: Being overweight or obese comprises a significant risk factor for atherosclerosis. Fat tissue also generates factors stimulating angiogenesis, the process by which new blood vessels form. The purpose of this paper is to assess concentrations of the vascular endothelial growth factor A (VEGF-A) and its soluble type-1 and type-2 receptors (sVEGFR-1 and sVEGFR-2) in plasma of patients with peripheral arterial disease (PAD) depending on the level of nutrition according to body mass index (BMI). Methods: The study group included patients suffering from symptomatic PAD (n=46) in Fontaine classes IIa-IV without any history of neoplastic disease and who have a normal BMI (n=15), are overweight (n=21) or are obese (n=10). The control group (n=30) consisted of healthy non-smoking volunteers who were neither overweight nor obese. Venous blood plasma samples were collected from both groups at rest in the morning to determine plasma concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 using the enzymelinked immunosorbent assay (ELISA) method. Results: The group of patients with PAD co-existent with being overweight or obese tended to have higher mean concentration levels of VEGF-A and sVEGFR-2 when compared with patients suffering from PAD with normal BMI. A statistically significant positive correlation was obtained between BMI and average plasma concentrations of sVEGFR-2 (R=0.37, P=0.0103). However, no significant correlation was noticed between BMI and VEGF-A or sVEGFR-1 concentrations. Conclusions: A positive correlation determined between the level of antiangiogenic factor and BMI value may be indicative of the linearly growing prevalence of some antiangiogenic factors in patients with metabolic disorders, which may be one of numerous factors contributing to incomplete efficiency of collateral circulation development in patients with PAD.

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“…Bioavailable IGF-I is increased by hyperinsulinemia in obese individuals as a consequence of insulin induced decreases in IGF binding proteins [52]. Notably, VEGF is also induced by elevated insulin and IGF-I levels associated with obesity [55] and aggressive cancers [56,57].…”

Section: Insulin and Insulin Like Growth Factorsmentioning

confidence: 99%

Signalling Pathways Implicated in Obesity Associated Cancers

Drew¹

2014

TOOBESJ

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Abstract:Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of an increasing number of human cancers. The predicted economic burden is causing significant concern. This has prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of metabolic processes and associated signalling pathways are associated with the development of obesity. These include a number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals. Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more effective combinatorial and multi-targeted cancer therapies in the future.

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Evidence for a Relationship between VEGF and BMI Independent of Insulin Sensitivity by Glucose Clamp Procedure in a Homogenous Group Healthy Young Men

Cited by 81 publications

References 33 publications

VEGF-A i PDGF-BB — czynniki angiogenne a stopień zaawansowania zespołu stopy cukrzycowej

VEGF-A i PDGF-BB — czynniki angiogenne a stopień zaawansowania zespołu stopy cukrzycowej

Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia

Signalling Pathways Implicated in Obesity Associated Cancers

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