Evidence for a primary cortical origin of a middle latency auditory evoked potential in cats

Kaga, Kimitaka; Hink, Robert F.; Shinoda, Yoshikazu; Suzuki, Jun–ichi

doi:10.1016/0013-4694(80)90153-4

Cited by 150 publications

(32 citation statements)

References 24 publications

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“…Using MLAEP to judge improvement in the wakeful level is useful, since the appearance of each component depends upon the normal function of the brain stem (Kaga et al 1980). The auditory cortex of the superior temporal gyrus was suggested as the generator source of Pa, based on many clinical reports of missing or abnormal Pa components in subjects with temporal lobe lesions (Graham et al 1980;Kraus et al 1982;Ozdamar et al 1982;Rosati et al 1982;Ozdamar and Kraus 1983), and on topographical mapping (Lee et al 1984) and parametric studies (Erwin and Buchwald 1986a, b).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acupuncture Stimulation on the Middle Latency Auditory Evoked Potential.

Liao¹,

Nakanishi²,

Nishikawa

1993

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

The Effect of Acupuncture Stimulation on the Middle Latency Auditory Evoked Potential.

Liao¹,

Nakanishi²,

Nishikawa

1993

Tohoku J. Exp. Med.

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“…N 0 and P 0 are likely exclusively the result of subcortical sources. The scalp potential field configuration observed for N a [Deiber et al, 1988] suggested a deep generator, possibly located at the midbrain or thalamus level, which would not produce a magnetic compo- Picton et al [1974Picton et al [ , 2000 Ponton et al [2000] (human, Vx latency) Di [1990, 1991] Miyazato et al [1995, 1999] Simpson and Knight [1993a (rat, Vx, ACx) Kraus et al [1985Kraus et al [ , 1988 (guinea pig, Vx, ACx) Kaga et al [1980] Buchwald et al [ ] Reese et al [1995a (cat, Vx, ACx) Steinschneider et al [1995] (monkey, depth CSD) Liégeois et al [1991Liégeois et al [ , 1994Liégeois et al [ , 1999 (human, epidural) Howard et al [1996Howard et al [ , 2000 nent due to a radial orientation. According to Deiber et al, the potential field for P a is different from that for N a , suggesting that distinct generators are responsible for these two components.…”

Section: Middle Latency Responsementioning

confidence: 99%

The Neurophysiology of Auditory Perception: From Single Units to Evoked Potentials

Eggermont

Ponton²

2002

Audiol Neurotol

172

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Evoked electric potential and magnetic field studies have the immense benefit that they can be conducted in awake, behaving humans and can be directly correlated with aspects of perception. As such, they are powerful objective indicators of perceptual properties. However, given a set of evoked potential and/or evoked field waveforms and their source locations, obtained for an exhaustive set of stimuli and stimulus contrasts, is it possible to determine blindly, i.e. predict, what the stimuli or stimulus contrasts were? If this can be done with some success, then a useful amount of information resides in scalp-recorded activity for, e.g., the study of auditory speech processing. In this review, we compare neural representations based on single-unit and evoked response activity for vowels and consonant-vowel phonemes with distinctions in formant glides and voice onset time. We conclude that temporal aspects of evoked responses can track some of the dominant response features present in single-unit activity. However, N₁ morphology does not reliably predict phonetic identification of stimuli varying in voice onset time, and the reported appearance of a double-peak onset response in aggregate recordings from the auditory cortex does not indicate a cortical correlate of the perception of voicelessness. This suggests that temporal aspects of single-unit population activity are likely not inclusive enough for representation of categorical perception boundaries. In contrast to population activity based on single-unit recording, the ability to accurately localize the sources of scalp-evoked activity is one of the bottlenecks in obtaining an accessible neurophysiological substrate of perception. Attaining this is one of the requisites to arrive at the prospect of blind determination of stimuli on the basis of evoked responses. At the current sophistication level of recording and analysis, evoked responses remain in the realm of extremely sensitive objective indicators of stimulus change or stimulus differences. As such, they are signs of perceptual activity, but not comprehensive representations thereof.

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“…Other evidence for a cortical origin of MLRs (especially wave Pa) involving primary auditory and/or association cortex stems largely from intracranial recordings in humans (7,(25)(26)(27)(28)(29) and studies in patients with temporal lobe lesions (30)(31)(32). Studies in the cat implicate the auditory cortex as a generator site for the analogue of wave Pa (33). Although the issue of the generator(s) of middle latency components remains unresolved (e.g., see 12), most evidence favors primary and association auditory cortex involvement, particularly for wave Pa. Given the sensitivity of cortex, particularly frontal cortex, to anoxia and the fact that many of the daytime symptoms of apneics could be reflective of cortical impairment and are similar to the effects of acute impairment of cerebral oxygenation, one might predict that middle and/or long latency evoked responses would be affected either acutely during oxygen deprivation or chronically as a result of repeated insults by the high frequency of apneas and extremes of oxygen desaturation observed in cases of severe apnea, such as in our subjects.…”

Section: Discussionmentioning

confidence: 99%

Middle Latency Auditory Evoked Potentials Sleep Apneics During Waking and as a Function of Arterial Oxygen Saturation During Apneas

Mosko

Knipher

Sassin

et al. 1984

Sleep

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Summary: In adults with obstructive sleep apnea middle latency auditory evoked responses were recorded as a function of apnea-related arterial oxygen desaturation both before sleep onset and during nocturnal sleep. In waking, wave Pa latency was normal in five of six subjects, and Pa amplitude was normal in all. During sleep apneas, wave Pa remained stable even during intervals of severe oxygen desaturation (e.g., 45-90% and 50-84% saturation in two subjects). Furthermore, wave Pa recorded immediately on awakening in the morning was unaltered compared with the response recorded just prior to sleep onset, despite a high frequency of nocturnal apneas in all subjects. These data indicate that repetitive nocturnal oxygen desaturation associated with severe obstructive sleep apnea syndrome has neither immediate nor cumulative measurable effects on the functioning of neurons that sub serve the middle latency evoked response. These findings are discussed in relation to a possible cortical contribution to the middle latency response. Key Words: Evoked potentials-Sleep apnea-Middle latency auditory evoked potentials.. InPatients with sleep apnea syndrome exhibit a variable constellation of physiological, behavioral, and psychological manifestations (see 1, for review). These may include hypnagogic hallucinations, enuresis, nightmares, abnormal motor activity during sleep, and morning awakening with headache and/or confusional states with memory impairment and spatial and temporal disorientation. Daytime functioning can be further compromised by incapacitating sleepiness, excessive fatigability, dizziness, impaired concentration, automatic behaviors (often with retrograde amnesia), personality changes (irritability, anxiety, depression), impotence, and diminished libido. This spectrum of clinical findings raises the possibility that brain function may be compromised by the repeated episodes of oxygen deprivation that accompany sleep apneas, and/or that apneas are a manifestation of central nervous system (eNS) dysfunction. Transient apnea-related decreases in arterial oxygen

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Evidence for a primary cortical origin of a middle latency auditory evoked potential in cats

Cited by 150 publications

References 24 publications

The Effect of Acupuncture Stimulation on the Middle Latency Auditory Evoked Potential.

The Effect of Acupuncture Stimulation on the Middle Latency Auditory Evoked Potential.

The Neurophysiology of Auditory Perception: From Single Units to Evoked Potentials

Middle Latency Auditory Evoked Potentials Sleep Apneics During Waking and as a Function of Arterial Oxygen Saturation During Apneas

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