Evidence for a post-Columbian introduction of human T-cell lymphotropic virus [type I] [corrected] in Latin America.

Dooren, Sonia Van; Gotuzzo, Eduardo; Salemi, Marco; Watts, Douglas M.; Audenaert, Elke; Duwe, Susanne; Ellerbrok, Heinz; Grassmann, Ralph; Hagelberg, Erika; Desmyter, Jan; Vandamme, Anne‐Mieke

doi:10.1099/0022-1317-79-11-2695

Cited by 77 publications

(95 citation statements)

References 74 publications

(47 reference statements)

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“…Third, if the virus had been introduced a long time ago, it would have been more prevalent. Therefore, the African origin of the Amerindian strains is very likely and is supported by recent results providing evidence for post-Colombian introduction of HTLV-I into Latin America (Van Dooren et al, 1998).…”

Section: The Origin Of Htlv-i Infection In French Guianasupporting

confidence: 55%

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Kazanji

Gessain

2003

Cad. Saúde Pública

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We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984. French Guiana is an overseas French administrative district located between Key words Retroviridae; HTLV-I; HTLV-II; Genetic Variability; T-cell Leukemia Resumo Os autores apresentam uma revisão dos estudos epidemiológicos realizados pelo seu grupo de pesquisa sobre a infecção pelos vírus T-linfotrópicos humanos tipo I (HTLV-I) e tipo II (HTLV-II) e doenças associadas na Guiana Francesa, desde 1984. A Guiana Francesa é um

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Section: The Origin Of Htlv-i Infection In French Guianasupporting

confidence: 55%

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Kazanji

Gessain

2003

Cad. Saúde Pública

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“…No sera were HIV/HTLV co-infected. Although Peru harbors four different ethnic groups: the Quechuas of Inca origin, Nikkei of Japanese descent, Mestizo of mixed white-Indian, and blacks or mulattos of African origin, HTLV-1 has been detected in all groups, and a molecular clock study confirmed a post-Columbian introduction of virus in the country 27 .…”

Section: Resultsmentioning

confidence: 92%

Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru

Quispe

Feria²,

Santos-Fortuna

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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SuMMarYEpidemiological studies conducted in Peru disclosed HTLV-1 to be prevalent in different ethnic groups, and found HTLV-2 in some Amazonian Indians and in men who have sex with men. No data concerning HTLV-1/2 infection in blood donors from Arequipa, a highlands region in southern Peru, is available. We searched for the presence of HTLV-1 and HTLV-2 antibodies in 2,732 serum samples obtained from blood donors from this geographic area. HTLV-1/2-specific antibodies were detected using an enzyme-linked immunosorbent assay (ELISA) and were confirmed by Western blot (WB). Reactive sera had their blood bags discarded from donation, and the demographic characteristics of the donors were analyzed. Thirty-five sera (1.2%) were HTLV seroreactive by ELISA, and 25 were confirmed HTLV-1-positive by WB. One serum disclosed HTLV-positivity, and the remaining nine serum samples showed indeterminate results by WB; three of which had an HTLV-1 indeterminate Gag profile. The median age of HTLV-positive individuals was 34.6 years; 27 were male and eight were female. All individuals were from southern Peru: 27 from Arequipa, five from Puno, and three from Cuzco. HTLV co-positivity with hepatitis B (five sera) and syphilis (one serum) were detected. Previous transfusion and tattooing were observed in two and one individuals, respectively. No serum was positive for HTLV/HIV co-infection. This study confirmed, for the first time, HTLV-1 infection and the absence of HTLV-2 infection in blood donors from Arequipa, Peru and suggests vertical transmission as the major route of HTLV-1 transmission and acquisition in this geographic region.

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“…The geographical origins of the strains other than those from Guyana, Suriname, and French Guiana reported in the cosmopolitan HTLV-1 subtype A are as follows, from top to bottom: PT12, PT3, and PT5, Brazil; PT1 and PT18, Caribbean; Abel2, Reunion Island; PH121, Senegal; CH, Caribbean; ARGMF, Argentina; TSP1, MEL, ATK, H5, OUL, AKR, AKE, MAP, BAT, and MT2, Japanese group; HS35, Caribbean; SIE and SIK, Ivory Coast; PH122, Senegal; and PH333, Mauritania. The sequences in the phylogenetic tree are reported elsewhere (12,13,23,24,46,49,50 closely related to the strains from French Guiana derived from Amerindians and Creoles and to some strains from Brazil.…”

Section: Resultsmentioning

confidence: 99%

High Seroprevalence of Human T-Cell Lymphotropic Virus Type 1 in Blood Donors in Guyana and Molecular and Phylogenetic Analysis of New Strains in the Guyana Shelf (Guyana, Suriname, and French Guiana)

Pouliquen

Hardy²,

Lee

et al. 2004

J Clin Microbiol

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The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 in blood donors in Guyana has never been estimated. We evaluated the prevalence of these viruses in blood donors by enzyme-linked immunosorbent assay and Western blotting and showed a prevalence of HTLV-1 of 1.3%; no HTLV-2 was detected. Female donors had a much higher HTLV-1 seroprevalence (3.6%) than male donors (0.7%). HTLV-1-seropositive donors tended to be slightly older than the average age for the total pool of donors. We also investigated the phylogenetic and molecular characteristics of HTLV-1 strains in Guyana and compared them with those identified in Suriname and French Guiana. Analysis of portions of the env and long terminal repeat nucleotide sequences showed that all the strains in Guyana and Suriname, like those in French Guiana, belonged to the transcontinental group of cosmopolitan subtype A. The similarities were greater between strains from Suriname and Guyana than between strains from Suriname and Guyana and those from French Guiana. Nevertheless, our results confirm that the HTLV-1 strains in all three countries have a common African origin.

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Evidence for a post-Columbian introduction of human T-cell lymphotropic virus [type I] [corrected] in Latin America.

Abstract: To investigate the origin and dissemination of human T-cell lymphotropic virus type I in Latin

Cited by 77 publications

References 74 publications

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru

High Seroprevalence of Human T-Cell Lymphotropic Virus Type 1 in Blood Donors in Guyana and Molecular and Phylogenetic Analysis of New Strains in the Guyana Shelf (Guyana, Suriname, and French Guiana)

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