Evidence for a new class of mutagens in diesel particulate extracts

Ball, James C.; Young, Willie C.

doi:10.1021/es00035a016

Cited by 14 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic exposure to relatively low levels of diesel exhaust may be a risk factor to human cancer (NIOSH, 1988;IARC, 1989). Many epidemiological studies conducted on workers, occupationally exposed to diesel exhaust, indicate an increased relative risk of developing lung cancer (Ball and Young, 1992;Masson et al, 1992;Westerholm et al, 1991). The diesel emissions are of high concern because of its air toxics content which includes aromatic compounds (such as benzene, toluene, 1-3 butadiene, PAH), various aldehydes, alkanes, alkenes, and ketones.…”

Section: Introductionmentioning

confidence: 99%

Profile of PAHs in the Diesel Vehicle Exhaust in Delhi

Khillare

Balachandran

Hoque

2005

Environ Monit Assess

View full text Add to dashboard Cite

A preliminary study to determine the profile of PAHs in the exhaust of diesel vehicles plying on Delhi roads was conducted. Two different types of diesel vehicles (buses and trucks) with different age groups were selected for sampling purpose. The concentration of Total PAHs (sigma12 PAHs) was found to be 50.76 +/- 6.62 and 57.72 +/- 4.15 mg/g in the exhaust of buses and trucks, respectively. The levels of PAHs were found to be high in trucks as compared to that of buses. The total PAHs concentration in the present study was found to be higher as compared to other studies. Such a high concentration could be attributed to different parameters like the age of the vehicles, driving conditions, the fuel quality and the emission standards.

show abstract

Section: Introductionmentioning

confidence: 99%

Profile of PAHs in the Diesel Vehicle Exhaust in Delhi

Khillare

Balachandran

Hoque

2005

Environ Monit Assess

View full text Add to dashboard Cite

show abstract

“…Most epidemiology studies from many countries indicate a smoking-adjusted risk of lung cancer in urban over countryside areas that is higher by a factor of up to 1.5 (7). Thus, there is considerable interest in the identification of polar, environmental mutagens (6,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Some polar PAC, like nitropyrenes, are relatively easy to measure (by gas chromatography-mass spectrometry; GC-MS), so their environmental occurrence has been studied widely (19).…”

mentioning

confidence: 99%

Polar Forms of Benzo[a]pyrene May Be Ubiquitous in the Environment

Ismail¹,

Lafleur²,

Giese³

1998

Environ. Sci. Technol.

View full text Add to dashboard Cite

“…Regulated air pollutants include carbon monoxide (CO), nitrogen oxides (NO x ), hydrocarbons (HC), and particulates (2). A group of compounds present in diesel and gasoline engine exhausts which are known for its carcinogenic and/or mutagenic potential but unregulated by law are the polycyclic aromatic compounds (PAHs) (3,4). Diesel exhaust was classified as probable carcinogen (group 2 A) to humans by the International Agency for Research on Cancer (IARC) in 1989 (5).…”

mentioning

confidence: 99%

Development of an Enzyme-Linked Immunosorbent Assay for 1-Nitropyrene

Knopp

Väänänen

Zühlke

1997

ACS Symposium Series

View full text Add to dashboard Cite

An enzyme-linked immunosorbent assay (ELISA) was developed for 1-nitropyrene. For hapten syntheses pyrenebutyric acid was nitrated yielding a mixture of 4-(6-nitropyrene-1-y1)-and 4-(8-nitropyrene-1 -y1)-butyric acid isomers that could not be separated. High titered antisera were obtained in rabbits after immunization with a KLH immunogen prepared with the mixture of isomers. As coating antigen a corresponding BSA conjugate was used. The calibration curve was linear in the 0.1 to 10 ppb range with a center point at 1.5 ppb and an LOD of 0.02 ppb in 10:90 acetonitrile/water (v/v). The average coefficients of variation were 4.9 and 7.8% over the range of the standard curve for intra-and interassay precision. Interference caused by 1,6-and 1,8-dinitropyrenes was observed. The effect of different concentrations of solvents on the antibody-analyte interaction was studied.

show abstract

Evidence for a new class of mutagens in diesel particulate extracts

Cited by 14 publications

References 13 publications

Profile of PAHs in the Diesel Vehicle Exhaust in Delhi

Profile of PAHs in the Diesel Vehicle Exhaust in Delhi

Polar Forms of Benzo[a]pyrene May Be Ubiquitous in the Environment

Development of an Enzyme-Linked Immunosorbent Assay for 1-Nitropyrene

Contact Info

Product

Resources

About