Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica

Roberts, John A.; Widjayanti, S.; Estuningsih, E.; Hetzel, D. J. S.

doi:10.1016/s0304-4017(96)01068-0

Cited by 16 publications

(3 citation statements)

References 7 publications

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“…Such evidence demonstrating a consistent variability in parasite burdens may suggest a genetic advance underpinning a natural resistance to infection. The fact that breed is an important factor in resistance to Fasciola gigantica infection, for example Indonesian Thin Tail is a well-known breed that demonstrates a high level of resistance to infection indicates that genotype may also play an important role in resistance against F. hepatica in sheep (28)(29)(30). However, there is no report of breed-specific resistance in sheep infection against this parasite (16).…”

Section: Discussionmentioning

confidence: 99%

IL‐10 and TGF‐β1 are associated with variations in fluke burdens following experimental fasciolosis in sheep

Haçarız

Sayers

Flynn

et al. 2009

Parasite Immunology

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Infection with Fasciola hepatica causes an economically important disease in ruminants. Variability in parasite load may indicate innate differences in the host immune system. This study aimed to investigate the immunological mechanisms that are associated with variability in parasite burden following experimental F. hepatica infection in cross-bred sheep. Of a total of 16 animals, four were randomly chosen as uninfected controls, and the remainder infected with 100 viable metacercariae. Uninfected animals were used as the control group for evaluation of cytokine gene expression levels. For comparative analysis, specific animals were selected on the basis of extremes of fluke burdens, and were categorised into light (n = 4) and heavy burdened (n = 3) cohorts. Serum antibody levels, haematological parameters, and expression of IL-4 and IFN-gamma genes in hepatic lymph nodes were equivalent in both groups. However, significant differences in mitogen-specific lymphocyte proliferation in vitro and in expression of TGF-beta1 and IL-10 genes in hepatic lymph nodes were observed at acute and chronic phases of infection, respectively. These results provide useful information in developing further understanding of natural resistance to fasciolosis in sheep.

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Section: Discussionmentioning

confidence: 99%

IL‐10 and TGF‐β1 are associated with variations in fluke burdens following experimental fasciolosis in sheep

Haçarız

Sayers

Flynn

et al. 2009

Parasite Immunology

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show abstract

“…At post‐mortem, the major bile ducts of each animal were examined for Fasciola liver flukes. Liver flukes in the liver were less obvious and involved dissection of the liver tissue as previously described (18). Liver fluke numbers were estimated from a sum of intact liver flukes plus the higher number of heads or tails from the fragmented liver flukes.…”

Section: Methodsmentioning

confidence: 99%

Resistance to liver fluke infection in the natural sheep host is correlated with a type‐1 cytokine response

Pleasance

Wiedosari

Raadsma

et al. 2011

Parasite Immunology

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Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that different anatomical tissues display distinct cytokine profiles consistent with liver fluke migration. The study also reveals a significant difference in the cytokine and antibody profiles of ITT sheep infected with F. gigantica compared with F. hepatica, with a higher ratio of IL-4/IFN-γ mRNA expression and specific IgG1/IgG2 antibodies strongly correlating with pathology. Interestingly, the significant type-1 cytokine profile occurred in the lymph node closest to the site of infection at a time when the effective immune response against F. gigantica liver flukes is thought to occur. When the same F. gigantica infection in the resistant ITT sheep was compared with the susceptible Merino breed, the resistant type-1 phenotype against liver fluke infection was only observed in the ITT sheep. These studies provide the first evidence to suggest that the induction of an early type-1 immune response in this natural sheep host may be responsible for the ability to resist liver fluke infection.

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“…There have been some reports in sheep of breeds resistant to Fasciola hepatica (Boyce et al, 1987) and Fasciola gigantica (Wiedosari and Copeman, 1990;Roberts et al, 1997a). While this review will concentrate on resistance to GI nematodes there is scope for further research on host genetic resistance to Trematodes (flukes), especially given the recent report of a major gene controlling resistance to Fasciola gigantica in Indonesian Thin Tail sheep (Roberts et al, 1997b).…”

Section: Parasites Species and Mode Of Infectionmentioning

confidence: 99%

Genetic resistance to endoparasites in sheep and goats. A review of genetic resistance to gastrointestinal nematode parasites in sheep and goats in the tropics and evidence for resistance in some sheep and goat breeds in sub-humid coastal Kenya

Baker

1998

Anim. Genet. Resour. Inf.

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SummaryThe evidence for both between- and within- breed genetic variation for resistance to gastrointestinal (GI) nematode parasites is reviewed. It is concluded that much of the published research on breed characterisation for resistance suffers from poor experimental design. Prior to the initiation of a 6-year study that has just been completed in coastal Kenya there were no estimates of within-breed genetic variation (i.e. heritabilities) of resistance in sheep or goats in the tropics. This study has confirmed that Red Maasai sheep and Small East African (SEA) goats are more resistant to GI parasites (predominantly Haemonchus contortus) than Dorper sheep and Galla goats. Heritability estimates for logarithm transformed faecal egg counts (an indicator of resistance) in 8-month-old lambs was 0.18±0.08 for all lambs, but higher in the susceptible Dorper-sired lambs (0.35±0.16) than in the resistant Red Maasai-sired lambs (0.06±0.07). This difference in heritability suggests that many centuries of natural selection have fixed most of the genes for resistance in the Red Maasai sheep. The resistant Red Maasai sheep and SEA goats were two to three times more productive than the susceptible Dorper sheep and Galla goats in the sub-humid coastal Kenya environment.

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Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica

Cited by 16 publications

References 7 publications

IL‐10 and TGF‐β1 are associated with variations in fluke burdens following experimental fasciolosis in sheep

IL‐10 and TGF‐β1 are associated with variations in fluke burdens following experimental fasciolosis in sheep

Resistance to liver fluke infection in the natural sheep host is correlated with a type‐1 cytokine response

Genetic resistance to endoparasites in sheep and goats. A review of genetic resistance to gastrointestinal nematode parasites in sheep and goats in the tropics and evidence for resistance in some sheep and goat breeds in sub-humid coastal Kenya

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