Evidence for a Link of SDPR and Cytoskeleton

Bao-xia, Zhang; Zhu, Jun; Ma, Liqiao; Li, Yuyin; Diao, Aipo; Li, Yinchuan

doi:10.1007/978-3-662-45657-6_17

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…The caveolar neck proteins are also linked to the actin filaments, as EHD2 that associates with F-actin [ 54 , 55 ] and Pacsin2 that binds directly to F-actin through its F-BAR domain [ 155 ] and through its SH3 domain to dynamin-2, N-WASP, and the small GTPase Rac1, which regulate actin cytoskeleton [ 52 , 156 , 157 ]. Cavin-2 colocalizes with cortactin, which recruits actin polymerization proteins, such as Arp2/3 [ 158 ]. Additionally, Cavin3 and ROR1 can also bind to the motor protein Myosin-1c, involved in cellular transport and endocytosis regulation, controlling caveolae presence at the PM [ 60 , 159 , 160 ].…”

Section: Interaction Between Caveolae and Cytoskeletonmentioning

confidence: 99%

Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Sotodosos-Alonso

Pulgarín-Alfaro

Pozo

2023

Cells

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The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction process. They respond to PM tension changes by flattening, contributing to the buffering of high-range increases in mechanical tension, while novel structures termed dolines, sharing Caveolin1 as the main component, gradually respond to low and medium forces. Caveolae are associated with different types of cytoskeletal filaments, which regulate membrane tension and also initiate multiple mechanotransduction pathways. Caveolar components sense the mechanical properties of the substrate and orchestrate responses that modify the extracellular matrix (ECM) according to these stimuli. They perform this function through both physical remodeling of ECM, where the actin cytoskeleton is a central player, and via the chemical alteration of the ECM composition by exosome deposition. Here, we review mechanotransduction regulation mediated by caveolae and caveolar components, focusing on how mechanical cues are transmitted through the cellular cytoskeleton and how caveolae respond and remodel the ECM.

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