Evidence for a heritable predisposition to Chronic Fatigue Syndrome

Albright, Frederick S.; Light, Kathleen C.; Light, Alan R.; Bateman, Lucinda; Cannon-Albright, Lisa

doi:10.1186/1471-2377-11-62

Cited by 70 publications

(61 citation statements)

References 36 publications

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“…Significant excess relatedness was observed for both close (p <0.001) and distant relationships (p = 0.010). Significant excess relative risk for CFS/ME was found between first (2.70, 95% CI: 1.56–4.66), second (2.34, 95% CI: 1.31–4.19), and third degree relatives (1.93, 95% CI: 1.21–3.07) (Albright, et al, 2011). …”

Section: Biomarkers Of Chronic Fatigue Syndrome/myalgic Encephalomyelmentioning

confidence: 99%

Biomarkers for chronic fatigue

Klimas

Broderick

Fletcher

2012

Brain, Behavior, and Immunity

133

127

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Fatigue that persists for 6 months or more is termed chronic fatigue. Chronic fatigue (CF) in combination with a minimum of 4 of 8 symptoms and the absence of diseases that could explain these symptoms, constitute the case definition for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Inflammation, immune system activation, autonomic dysfunction, impaired functioning in the hypothalamic-pituitary-adrenal axis, and neuroendocrine dysregulation have all been suggested as root causes of fatigue. The identification of objective markers consistently associated with CFS/ME is an important goal in relation to diagnosis and treatment, as the current case definitions are based entirely on physical signs and symptoms. This review is focused on the recent literature related to biomarkers for fatigue associated with CFS/ME and, for comparison, those associated with other diseases. These markers are distributed across several of the body’s core regulatory systems. A complex construct of symptoms emerges from alterations and/or dysfunctions in the nervous, endocrine and immune systems. We propose that new insight will depend on our ability to develop and deploy an integrative profiling of CFS/ME pathogenesis at the molecular level. Until such a molecular signature is obtained efforts to develop effective treatments will continue to be severely limited.

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Section: Biomarkers Of Chronic Fatigue Syndrome/myalgic Encephalomyelmentioning

confidence: 99%

Biomarkers for chronic fatigue

Klimas

Broderick

Fletcher

2012

Brain, Behavior, and Immunity

133

127

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“…Noen studier om CFS/ME rapporterer om stressende livshendelser i månedene forut for debut av sykdommen (12,13) . Foreløpig vet man lite om hvilke gener som predisponerer for CFS/ME, men dette er gjenstand for kartlegging (14,15) .…”

Section: Disponerende Faktorerunclassified

Hva er egentlig myalgisk encefalopati?

Egeland¹,

Angelsen²,

Haug³

et al. 2015

Tidsskriftet

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Forfattere:Avdeling rehabilitering og sjeldne tilstander Trykk og layout: Andvord Grafisk as forord Helsedirektoratet har «følge med ansvar» for å vurdere utvikling av tjenestetilbud og om dette står i forhold til pasientgruppenes behov.På bakgrunn av erfaringer fra kontakter med pasienter, pårørende og fagpersoner er direktoratet gjort kjent med at barn, unge og voksne med CFS/ME og deres pårørende møter store utfordringer som i for liten grad ivaretas av tjenesteapparatet.Helsedirektoratets mål med denne veilederen er å bidra til faglig forsvarlighet, god kvalitet på tjenestene og tilnaermet likhet i tilbudet uansett hvor man bor som pasient med CFS/ME.Å gi helsetjenester til brukere som ikke har en klar og entydig anerkjent årsak til sin sykdom, stiller store krav til faglig kvalitet, profesjonalitet og utøvelse av tjenestetilbudet. Tidlig og riktig diagnose er viktig i et pasientforløp.Mange pasienter oppgir at de får et bedre liv når de har fått korrekt diagnose, aksepterer sykdommen og laerer seg gode mestringsstrategier for de utfordringer CFS/ME kan gi.Veilederen er utarbeidet slik at den favner et bredt felt av temaer.Veilederen bygger på dagens kunnskap og erfaring, de ordninger som er etablert i dag og gjeldende rettsregler. Det er lagt vekt på at dette først og fremst skal vaere en faglig veileder for helsepersonell.Veilederen vil bli revidert i takt med ny kunnskap.

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“…Although pathologic mechanisms [12] such as dysfunctions in the immune system [17, 18] and neuroendocrine system [19], chronic inflammation [20], an increase in gene expression following exercise [21] and brain inflammation [22] are found, the aetiology remains unclear. A heritable predisposition is suggested [23]. No cure is currently available; therefore, treatment aims at alleviating symptoms and fostering the mastery of challenges in daily life to improve functioning [24–26].…”

Section: Introductionmentioning

confidence: 99%

From good health to illness with post-infectious fatigue syndrome: a qualitative study of adults’ experiences of the illness trajectory

2017

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BackgroundMunicipal drinking water contaminated with the parasite Giardia lamblia in Bergen, Norway, in 2004 caused an outbreak of gastrointestinal infection in 2500 people, according to the Norwegian Prescription Database. In the aftermath a minor group subsequently developed post-infectious fatigue syndrome (PIFS). Persons in this minor group had laboratory-confirmed parasites in their stool samples, and their enteritis had been cured by one or more courses of antibiotic treatment. The study’s purpose was to explore how the affected persons experienced the illness trajectory and various PIFS disabilities.MethodsA qualitative design with in-depth interviews was used to obtain first-hand experiences of PIFS. To get an overall understanding of their perceived illness trajectory, the participants were asked to retrospectively rate their functional level at different points in time. A maximum variation sample of adults diagnosed with PIFS according to the international 1994 criteria was recruited from a cohort of persons diagnosed with PIFS at a tertiary Neurology Outpatient Clinic in Western Norway. The sample comprised 19 women and seven men (mean age 41 years, range 26–59). The interviews were fully transcribed and subjected to a qualitative content analysis.ResultsAll participants had been living healthy lives pre-illness. The time to develop PIFS varied. Multiple disabilities in the physical, cognitive, emotional, neurological, sleep and intolerance domains were described. Everyone more or less dropped out from studies or work, and few needed to be taken care of during the worst period. The severity of these disabilities varied among the participants and during the illness phases. Despite individual variations, an overall pattern of illness trajectory emerged. Five phases were identified: prodromal, downward, turning, upward and chronic phase. All reached a nadir followed by varying degrees of improvement in their functional ability. None regained pre-illness health or personal and professional abilities.ConclusionsThe needs of persons with this condition are not met. Early diagnosis and interdisciplinary rehabilitation could be beneficial in altering the downward trajectory at an earlier stage, avoiding the most severe disability and optimising improvement. Enhanced knowledge among health professionals, tailored treatment, rest as needed, financial support and practical help would likely improve prognosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12875-017-0614-4) contains supplementary material, which is available to authorized users.

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Evidence for a heritable predisposition to Chronic Fatigue Syndrome

Cited by 70 publications

References 36 publications

Biomarkers for chronic fatigue

Biomarkers for chronic fatigue

Hva er egentlig myalgisk encefalopati?

From good health to illness with post-infectious fatigue syndrome: a qualitative study of adults’ experiences of the illness trajectory

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