Evidence for a genetic etiology to ejaculatory dysfunction

Jern, Patrick; Santtila, Pekka; Johansson, Ada; Varjonen, Markus; Witting, Katarina; Pahlen, Bettina von der; Sandnabba, N. Kenneth

doi:10.1038/ijir.2008.61

Cited by 71 publications

(65 citation statements)

References 24 publications

(32 reference statements)

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“…A genetic etiology of PE in humans was previously suggested in 1940 [13] when Schapiro noted that PE seems to be familial. This conclusion has been supported in more recent publications by Jern et al [7] and Waldinger et al [14] . With selective 5-HT reuptake inhibitors successfully used in the treatment of PE, many scientists have focused their interest on 5-HT metabolization and its receptors.…”

Section: Discussionsupporting

confidence: 76%

“…Waldinger and colleagues [4][5][6] postulated LPE as a neurobiological dysfunction with a genetic vulnerability for short IELT related to decreased central 5-HT neurotransmission and/or 5-HT receptor dysfunction (i.e., hypofunction of the 5-HT 2C and/or 5-HT 1B receptors or hyperfunction of the 5-HT 1A receptor). Jern et al [7] conducted an investigation of 3,946 twins and their siblings that indicated a significant moderate genetic effect for PE.…”

Section: Introductionmentioning

confidence: 99%

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Association between Polymorphisms in the Serotonin 2C Receptor Gene and Premature Ejaculation in Han Chinese Subjects

Luo

Lu²,

Wang³

et al. 2010

Urol Int

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Introduction: Lifelong premature ejaculation (LPE) is characterized by persistently shorter intravaginal ejaculation latency time (IELT) than found acceptable by the patient or his partner. It has been postulated to be a neurobiological dysfunction with genetic vulnerability and is related to disturbances of central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and 5-HT receptor function. Aim: To investigate the relationship between the C–759T and G–697C polymorphisms of the 5-HT_2C receptor and LPE. Methods: A prospective study was conducted in 106 Han Chinese men with LPE, characterized by IELT of less than 1 min, and 84 healthy controls with IELT of more than 3 min. All subjects were genotyped for the C–759T and G–697C polymorphisms located in the promoter region of the 5-HT_2C receptor. The frequencies of genotypes and single nucleotide mutations were compared between the two groups. Results: Three genotypes were detected both in the men with LPE and in the control group: –759C/–697G, –759T/–697C, and –759C/ –697C. Genotype –759T/–697G was not detected. The frequency of genotype –759T/–697C was higher in patients with LPE than in the control group (30.2 vs. 11.9%, p < 0.05), whereas the frequency of genotype –759C/–697G was lower in patients with LPE than in the control group (66.0 vs. 83.3%, p < 0.05). No difference was found for genotype –759C/ –697C between the two groups. Mutations at –759T and –697C were more frequent in patients than in the control group (–759T: 30.2 vs. 13.3%, p < 0.05; –697C: 30.4 vs. 16.7%, p < 0.05, respectively). Conclusions: Our findings indicated that polymorphisms in the 5-HT_2C receptor gene are associated with LPE, and men who carry the –759T or –697C genotype have increased odds of premature ejaculation. Further investigation in this field is necessary.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Association between Polymorphisms in the Serotonin 2C Receptor Gene and Premature Ejaculation in Han Chinese Subjects

Luo

Lu²,

Wang³

et al. 2010

Urol Int

View full text Add to dashboard Cite

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“…The results of 21 responders were compared against 63 age matched controls from a population based sample of male twins and their brothers. 9 In the IIEF questionnaire scores over 25 indicate normal erectile function and scores 22-25 indicate mild dysfunction. 10 In this study erectile function was considered satisfactory if IIEF score was 22 or more.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Sexual Function in Patients Operated on for Bladder Exstrophy and Epispadias

2015

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“…Participants who had not engaged in partnered sexual activity during this time were excluded from further statistical analyses. The indicator variables were subjected to factor analyses to determine their reliability (see [ 5,11 ] for a more detailed description of this procedure). Factor analyses conducted on these indicator variables [ 11 ] have shown good factorability (Kaiser -Meyer -Olkin measure of sampling adequacy 0.62, Bartlett ' s test of sphericity chi-squared (6) 413.07, P < 0.001), with all items loading clearly on one factor containing 42.76% of the variance.…”

Section: Methodsmentioning

confidence: 99%

Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?

et al. 2012

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E 11 7 3What ' s known on the subject? and What does the study add? There is also evidence that the etiology of premature ejaculation is partially genetic. So far, all molecular genetic studies of premature ejaculation have focused on serotonergic and dopaminergic genes. Serotonergic and dopaminergic neurotransmission aside, studies on both animals and humans have shown that both oxytocin and vasopressin are also involved in ejaculatory function.The present study is, to our knowledge, the fi rst to investigate effects of polymorphisms in oxytocin and vasopressin receptor genes on ejaculatory function. Although a large sample (1517 men) was available for the present study, we could not detect any clear-cut effects of any gene varant on ejaculatory function. We detected a heterozygote effect of one polymorphism (rs75775) in the oxytocin receptor gene. Rare variants of the vasopressin receptor 1A gene may theoretically have a stronger impact on ejaculatory function, but would need a very large sample in order to be established. Based on our results, we conclude that the oxytocin and vasopressin receptor genes are unlikely targets for successful pharmacogenetic interventions. OBJECTIVES• To investigate associations between single nucleotide polymorphisms (SNPs) linked to the oxytocin, and arginine vasopressin 1A and 1B receptor genes and ejaculatory function.• To investigate these associations in a large, population-based sample. PATIENTS AND METHODS• In all, 1517 male twins and non-twin brothers of twins aged 18 -45 years (mean = 26.43; SD = 4.87) provided questionnaire data regarding ejaculatory function and relevant covariates and saliva samples for genotyping.• A Bayesian linear mixed-effects model, which appropriately controls for betweensubjects dependence, was used to estimate genotype associations.• We corrected for multiple testing using a linkage disequilibrium correlation measure. RESULTS• We found a heterozygote effect on one SNP in the oxytocin receptor gene (rs75775), so that individuals heterozygous for this SNP had signifi cantly elevated risk for premature ejaculation symptoms compared with carriers of either homozygote.• Several SNPs in the arginine vasopressin receptor genes had rare or very rare genotypes. This study may be underpowered to detect potential effects of rare genotypic variants in arginine vasopressin receptor genes. CONCLUSIONS• Our results regarding the oxytocin receptor polymorphisms support previous studies that indicate a complex relationship between oxytocin and ejaculatory function.• Oxytocin receptor genes are, for example, unlikely suitable targets for pharmacogenetic intervention studies.• Rare variants in arginine vasopressin receptor genes may have signifi cant effects on premature ejaculation, but would need larger sample sizes or case -control designs to be detected.

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Evidence for a genetic etiology to ejaculatory dysfunction

Cited by 71 publications

References 24 publications

Association between Polymorphisms in the Serotonin 2C Receptor Gene and Premature Ejaculation in Han Chinese Subjects

Association between Polymorphisms in the Serotonin 2C Receptor Gene and Premature Ejaculation in Han Chinese Subjects

Sexual Function in Patients Operated on for Bladder Exstrophy and Epispadias

Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?

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