2013
DOI: 10.1038/cdd.2013.49
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Evidence for a common progenitor of epithelial and mesenchymal components of the liver

Abstract: Tissues of the adult organism maintain the homeostasis and respond to injury by means of progenitor/stem cell compartments capable to give rise to appropriate progeny. In organs composed by histotypes of different embryological origins (e.g. the liver), the tissue turnover may in theory involve different stem/precursor cells able to respond coordinately to physiological or pathological stimuli. In the liver, a progenitor cell compartment, giving rise to hepatocytes and cholangiocytes, can be activated by chron… Show more

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Cited by 24 publications
(23 citation statements)
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“…From these transitional cells, a population of genetically marked hepatocytes, able to repopulate large areas of the hepatic parenchyma, emerged. Consistent with these results is the recent evidence, collected by Conigliaro et al (54), that metastable hepatic stem/progenitor cells, isolated from embryonic livers and established in clonally derived cell lines, give rise to both hepatocytes and HSCs when injected into normal growing liver.…”
Section: Liver Cells Undergo Cellular Transitionssupporting
confidence: 85%
See 1 more Smart Citation
“…From these transitional cells, a population of genetically marked hepatocytes, able to repopulate large areas of the hepatic parenchyma, emerged. Consistent with these results is the recent evidence, collected by Conigliaro et al (54), that metastable hepatic stem/progenitor cells, isolated from embryonic livers and established in clonally derived cell lines, give rise to both hepatocytes and HSCs when injected into normal growing liver.…”
Section: Liver Cells Undergo Cellular Transitionssupporting
confidence: 85%
“…Consistent with these results is the recent evidence, collected by Conigliaro et al . , that metastable hepatic stem/progenitor cells, isolated from embryonic livers and established in clonally derived cell lines, give rise to both hepatocytes and HSCs when injected into normal growing liver.…”
Section: Liver Cells Undergo Cellular Transitionsmentioning
confidence: 99%
“…Activation of EMT in cancer cells also leads to an increase in their tumor-initiating capabilities or transform them to being like CSCs-the therapy-resistant cancer cells that act as a reservoir for new, more differentiated tumor cells, as well as maintain the ability to self-renew for many generations, thereby initiating a tumor [82,83]. Recent studies show that cells undergoing partial EMT can gain 'stemness' that can be compromised significantly if cells undergo complete EMT and become mesenchymal-like [47,[84][85][86][87]; thereby highlighting another advantage of collectively migrating CTCs during metastatic progression. All these functional advantages of collective cell migration or hybrid E/M phenotype-resistance to cell death during circulation, higher plasticity to both colonize and reinitiate metastasis, and enhanced tumor-initiating abilities-might be attained only in the presence of the cell-cell communication based stabilizing interactions provided by NDJ signaling ( figure 9(B)).…”
Section: Discussionmentioning
confidence: 99%
“…Adult HSC coexpress mesodermal markers (eg, Lhx, Wilms tumour-1), ectodermal markers (eg, Nestin, GFAP)37–40 and endoderm-enriched genes (eg, FoxA2, HNF4α, albumin),5 41 plus transcription factors associated with stem/progenitor cells (eg, Nanog, Oct4) 37 42–45. Depending on culture conditions, HSC from adult livers can generate bone-like, fat-like, neural-like, cholangiocyte-like or hepatocyte-like cells,40 43 46 demonstrating inherent plasticity. Pancreatic stellate cells (which closely resemble HSC) repopulated the hepatocyte compartment when transplanted after PH,47 suggesting that some HSC can be reprogrammed in vivo.…”
Section: Discussionmentioning
confidence: 99%