Evidence for 2-Hydroxy-4(Methylthio) Butanoic Acid and dl-Methionine Having Different Dose Responses in Growing Broilers

Abstract

The objective of this study was to compare the gain-response curve to dietary levels of 2-hydroxy-4(methylthio) butanoic acid (HMTBA) and DL-Met (DLM) across 4 floor pen trials in which different diets were used. Six replicates of 38 or 41 birds per pen (trials 1 to 2 and 3 to 4, respectively) were used in a 2 x 3 factorial arrangement. A control with 12 replicates was also included. The 2 Met sources were fed at 3 equimolar levels equally spaced, with the highest level added at requirements from 1 to 48, 49, 43, or 49 d for trials 1, 2, 3, and 4, respectively. Commercial-type TSAA-deficient control diets contained sorghum, wheat, corn, or corn plus meat and bone meal for trials 1, 2, 3, and 4, respectively. Performance improved at all times for most parameters after supplementing with HMTBA or DLM (P < 0.05). No differences were found in the birds fed HMTBA or DLM at any age and trial (P > 0.05), except for trial 1, in which 17-d-old birds performed better when fed HMTBA than DLM (P < 0.05). In each trial, linear, quadratic, and exponential regressions were conducted upon the gain response of birds fed HMTBA and DLM separately. Equations with better goodness of fit were used to compare the estimated gain responses to feeding HMTBA vs. DLM. In 3 trials, the shape of the gain-response curve differed when feeding HMTBA vs. DLM. In trials 3 and 4, feeding HMTBA at commercial levels resulted in greater gain responses than DLM (P < 0.05), whereas, in trials 2 and 4, at very deficient levels, DLM-fed birds outperformed those fed HMTBA (P < 0.05). When the 4 trials were combined, the dose-response curve with the best goodness of fit was linear for HMTBA and quadratic for DLM. It can be concluded that the 2 Met sources have a different dose-response form, HMTBA could outperform DLM at commercial levels, and DLM could outperform HMTBA at deficient levels.

Effects of different methionine sources on production and reproduction performance, egg quality and serum biochemical indices of broiler breeders

“…The explanation could be that Met supplementation enhances protein deposition, thus promote the egg production. Furthermore, Met supplementation may improve production performance through polyamine metabolism pathways [1]. …”

“…Methionine (Met) plays critical roles in methylation reaction, protein accretion [1], growth performance promotion [2,3] and immune responses enhancement [4]. It is generally considered to be the first limiting amino acid in poultry diets.…”

Broiler responses to digestible total sulphur amino acids at different ages: a neural network approach

“…It has been well documented that broiler diets based upon soybean meal as the primary protein source are deficient in the total sulphur-containing amino acids (TSAA) methionine and cysteine (Almquist et al 1942). Methionine is an essential amino acid (AA) in poultry nutrition that plays important roles including protein synthesis, methyl donor for methylation reaction, a precursor of important intermediates in metabolic pathways and synthesis of polyamines (Vazquez-Anon et al 2006). There are many studies conducted to determine the TSAA requirement of broilers.…”

ALIMET® (análogo líquido de metionina hidroxilada) en el sistema inmunitario, población de microflora y rendimiento de broilers

“…Many studies have reported equivalent performance of broilers supplemented with DL-Met and DL-HMB on equimolar basis in the diets (Knight and Dibner, 1984;Garlich, 1985;Romer and Abel, 1999). However, there is conflict results in the last decade concerning the relative bioefficacy between DL-Met and DL-HMB in commercial broilers (Lemme et al, 2002;Daenner and Bessei, 2003;Dibner, 2003;Drew et al, 2003;Meirelles et al, 2003;Dibner et al, 2004;Motl et al, 2005;Liu et al, 2006;Vazquez-Anon et al, 2006a;Liu et al, 2007;Saki et al, 2011). Investigate of relative bioefficacy between synthetic Met sources and their effect on broiler performance is main focus of studies.…”