Evidence-Based Use of Pulsed Electromagnetic Field Therapy in Clinical Plastic Surgery

Strauch, Berish; Herman, Charles K.; Dabb, Richard W.; Ignarro, Louis J.; Pilla, Arthur A.

doi:10.1016/j.asj.2009.02.001

Cited by 107 publications

(84 citation statements)

References 49 publications

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“…Our numerical model demonstrates that by non-contact application of an EF, we can induce a sufficient EF in the cell membrane and cytoplasm to manipulate protein expression and activate intracellular pathways as supported by our experimental results [3]. Such numerical modelling of EF -cell interactions is an essential and necessary part of the clinical translation process; it helps to establish therapeutic concepts and to advance approaches toward the development of non-pharmacological EF therapies [106][107][108], which can be applied locally and without direct contact with tissue [101,105,[109][110][111][112]. Importantly, our theoretical approach can be generalized to investigate the interaction of EF with cells of an arbitrary shape.…”

Section: Resultsmentioning

confidence: 81%

Modulation of cell function by electric field: a high-resolution analysis

Taghian

Narmoneva

Kogan

2015

J. R. Soc. Interface.

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Regulation of cell function by a non-thermal, physiological-level electromagnetic field has potential for vascular tissue healing therapies and advancing hybrid bioelectronic technology. We have recently demonstrated that a physiological electric field (EF) applied wirelessly can regulate intracellular signalling and cell function in a frequency-dependent manner. However, the mechanism for such regulation is not well understood. Here, we present a systematic numerical study of a cell-field interaction following cell exposure to the external EF. We use a realistic experimental environment that also recapitulates the absence of a direct electric contact between the field-sourcing electrodes and the cells or the culture medium. We identify characteristic regimes and present their classification with respect to frequency, location, and the electrical properties of the model components. The results show a striking difference in the frequency dependence of EF penetration and cell response between cells suspended in an electrolyte and cells attached to a substrate. The EF structure in the cell is strongly inhomogeneous and is sensitive to the physical properties of the cell and its environment. These findings provide insight into the mechanisms for frequency-dependent cell responses to EF that regulate cell function, which may have important implications for EF-based therapies and biotechnology development.

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Section: Resultsmentioning

confidence: 81%

Modulation of cell function by electric field: a high-resolution analysis

Taghian

Narmoneva

Kogan

2015

J. R. Soc. Interface.

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“…Small differences in these field magnitudes can cause changes in the configuration of certain proteins, and produce effects at the cell and organism level [McCaig et al, 2005;Céspedes and Ueno, 2009]. These effects are reproducible and are currently being evaluated for therapeutic applications [Pilla, 2002[Pilla, , 2006Nuccitelli, 2003;Volpe, 2003;Balakatounis and Angoules, 2008;Colbert et al, 2009;Strauch et al, 2009]. However, the mechanism or mechanisms of action remain an open question [Eremenko et al, 1997;Harland et al, 1999;Cook et al, 2002;Barnes, 2006].…”

Section: Introductionmentioning

confidence: 97%

Reduction of the earth's magnetic field inhibits growth rates of model cancer cell lines

Martino

Portelli

McCabe

et al. 2010

Bioelectromagnetics

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Small alterations in static magnetic fields have been shown to affect certain chemical reaction rates ex vivo. In this manuscript, we present data demonstrating that similar small changes in static magnetic fields between individual cell culture incubators results in significantly altered cell cycle rates for multiple cancer-derived cell lines. This change as assessed by cell number is not a result of apoptosis, necrosis, or cell cycle alterations. While the underlying mechanism is unclear, the implications for all cell culture experiments are clear; static magnetic field conditions within incubators must be considered and/or controlled just as one does for temperature, humidity, and carbon dioxide concentration.

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“…A potential mechanism of action for PRFE therapy has been put forward and is reviewed by Strauch et al [28]. Moreover, recent reports have further contributed to understanding concerning the mechanisms of PRFE therapy for wound healing [29,30].…”

mentioning

confidence: 99%