Evidence Based Surgical Approach to Locally Advanced Gastric Cancer

Thakur, Basant Kumar; Devkota, Mukti; Sharma, Amit; Chaudhary, Monica

doi:10.33314/jnhrc.v0i0.2055

Cited by 8 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gastric cancer requires precise and detailed imaging diagnosis to support curative surgery. Both early and advanced stages require a treatment strategy that refers to resection or pre-operative oncologic options [24]. While the original staging of a gastric tumor is best after pathologic analysis, ensuring a precise clinical stage is of major importance to maximize therapeutic management.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Ultrasound vs. Computed Tomography for Gastric Cancer Staging: A Network Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

Gastric cancer preoperative staging is of outmost importance to assure proper management of the disease. Providing a relevant clinical stage relies on different imaging methods such as computed tomography (CT) or endoscopic ultrasound (EUS). We aimed to perform a network meta-analysis for gastric cancer clinical stage diagnostic tests, thus comparing the diagnostic accuracy of EUS vs. multidetector CT (MDCT) and EUS vs. EUS + MDCT. We plotted study estimates of pooled sensitivity and specificity on forest plots and summary receiver operating characteristic space to explore between-study variation in the performance of EUS, MDCT and EUS + MDCT for T1–T4, N0–N3, M0–M1 when data were available. Exploratory analyses were undertaken in RevMan 5. We included twelve studies with 2047 patients. Our results suggest that EUS was superior to MDCT in preoperative T1 and N staging. MDCT is more specific for the M stage but no significant difference in sensitivity was obtained. When comparing EUS vs. EUS + MDCT for T1 both sensitivity and specificity were not relevant. No significant differences were observed in T2–T4 stages. Even though EUS helped differentiate between the presence of invaded nodules, N stages should be carefully assessed by both methods since there is not sufficient data.

show abstract

Section: Discussionmentioning

confidence: 99%

Endoscopic Ultrasound vs. Computed Tomography for Gastric Cancer Staging: A Network Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…За статистичними даними, щорічно у світі реєструється понад 800 тис. випадків раку шлунка [4,9,11]. За даними Національного канцер-реєстру України, у структурі захворюваності та смертності серед злоякісних новоутворень рак шлунка стабільно посідає одне з чотирьох рангових місць із частотою виявлення близько 21 на 100 тис.…”

Section: клінічний випадокunclassified

Nakayama esophagoduodenostomy as a reconstructive stage after gastrectomy for gastric cancer complicated by acute bleeding and Krukenberg metastases. Clinical case

Ivanchov,

Hychka,

Prudnikova

et al. 2023

View full text Add to dashboard Cite

Purpose - on a clinical case to justify the technical aspects of applying the Nakayama esophago-duodenostomy as a reconstructive stage after gastrectomy for gastric cancer complicated by acute bleeding and Krukenberg metastases. Clinical case. Patient O., born in 1975, was being treated for stomach cancer complicated by moderate acute bleeding and Krukenberg metastases in the surgery department No. 3 of the Kyiv City Emergency Clinical Hospital. The patient general clinical, special laboratory and instrumental research methods were carried out (electrocardiography, esophagogastroduodenoscopy, ultrasound examination of the organs of the abdominal cavity and small pelvis, computer tomography of the organs of the abdominal cavity and small pelvis with intravenous contrast). The patient had cancer of the cardiac part of the stomach, complicated by moderate gastrointestinal bleeding with the presence of Krukenberg metastases, in connection with which the patient underwent surgery in the early delayed period according to a unique method - gastrectomy with lymphodissection in the volume of D2+ and overlapping esophageal-duodenal anastomosis according to the Nakayama type in the modification of the clinic. The patient was discharged in a satisfactory condition on the 10th day after surgery under the supervision of an oncologist and a surgeon at her place of residence. During the dynamic observation for 12 months, she felt satisfactory. Conclusions. Using the example of a clinical case, the technical aspects of applying the Nakayama esophagoduodenostomy as a reconstructive stage after gastrectomy for gastric cancer complicated by acute bleeding and Krukenberg metastases are substantiated. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

show abstract

“…Contemporary literature defines locally advanced gastric cancer (LAGC) as any entity larger than early gastric cancer or T2-T4 lesions. Others define LAGC as T3-T4 gastric malignancies requiring neoadjuvant treatment [6,7]. These patients usually have a poor prognosis compared to patients with early-stage GC [8].…”

Section: Introductionmentioning

confidence: 99%

Multivisceral Resection for Locally Advanced Gastric Cancer: A Systematic Review and Evidence Quality Assessment

Schizas,

Giannakodimos,

Mylonas

et al. 2023

JCM

View full text Add to dashboard Cite

Patients with locally advanced gastric cancer (LAGC) often require multivisceral resection (MVR) of the involved organs to achieve R0 resection and local disease control. The aim of the present study was to systematically review all available literature on the postoperative and long-term outcomes of MVR for gastric cancer. The PubMed database was systematically searched by two independent investigators for studies concerning MVR for LAGC. In total, 30 original studies with 3362 patients met our inclusion criteria. R0 resection was achieved in 67.77% (95% CI, 65.75–69.73%) of patients. The spleen, colon and pancreas comprised the most frequently resected organs in the context of MVR. Pancreatic fistulae (10.08%, 95% CI, 7.99–12.63%), intraabdominal abscesses (9.92%, 95% CI, 7.85–12.46%) and anastomotic leaks (8.09%, 95% CI, 6.23–10.45%) constituted the most common postoperative complications. Using the available data, we estimated the mean 1-year survival at 62.2%, 3-year survival at 33.05%, and 5-year survival at 30.21% for the entire cohort. The survival rates were mainly correlated with lymphatic invasion, tumor size and patient age. Therefore, gastrectomy, together with MVR, is feasible and may offer a survival advantage compared to gastrectomy alone or no other surgical treatment in a selected group of patients. Consequently, both patient and tumor characteristics should be carefully assessed to optimize candidate selection.

show abstract

Evidence Based Surgical Approach to Locally Advanced Gastric Cancer

Cited by 8 publications

References 0 publications

Endoscopic Ultrasound vs. Computed Tomography for Gastric Cancer Staging: A Network Meta-Analysis

Endoscopic Ultrasound vs. Computed Tomography for Gastric Cancer Staging: A Network Meta-Analysis

Nakayama esophagoduodenostomy as a reconstructive stage after gastrectomy for gastric cancer complicated by acute bleeding and Krukenberg metastases. Clinical case

Multivisceral Resection for Locally Advanced Gastric Cancer: A Systematic Review and Evidence Quality Assessment

Contact Info

Product

Resources

About