Evidence‐based source modeling of nociceptive cortical responses: A direct comparison of scalp and intracranial activity in humans

Bradley, Claire; Bastuji, Hélène; Garcia-Larrea, Luis

doi:10.1002/hbm.23812

Cited by 15 publications

(18 citation statements)

References 69 publications

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“…Such significant changes of electrophysiological global network measures have been observed in different neurological and psychiatric disorders such as Alzheimer's disease (Stam, Jones, Nolte, Breakspear, & Scheltens, 2007;Yu et al, 2017), multiple sclerosis, and epilepsy (Stam, 2014). Although such changes have not directly been shown in chronic pain so far, fMRI studies reporting a global reorganization of the brain in chronic pain (Mano et al, 2018;Mansour et al, 2016) [Bradley et al, 2017]). T-maps of the seed-based connectivity contrasts between pain and control conditions are depicted (left and right side).…”

Section: Discussionmentioning

confidence: 98%

Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans

Nickel

Dinh

et al. 2019

Human Brain Mapping

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Pain is a complex phenomenon that is served by neural oscillations and connectivity involving different brain areas and frequencies. Here, we aimed to systematically and comprehensively assess the pattern of neural oscillations and connectivity characterizing the state of tonic experimental pain in humans. To this end, we applied 10‐min heat pain stimuli consecutively to the right and left hand of 39 healthy participants and recorded electroencephalography. We systematically analyzed global and local measures of oscillatory brain activity, connectivity, and graph theory‐based network measures during tonic pain and compared them to a nonpainful control condition. Local measures showed suppressions of oscillatory activity at alpha frequencies together with stronger connectivity at alpha and beta frequencies in sensorimotor areas during tonic pain. Furthermore, sensorimotor areas contralateral to stimulation showed significantly increased connectivity to a common area in the medial prefrontal cortex at alpha frequencies. Together, these observations indicate that the state of tonic experimental pain is associated with a sensorimotor‐prefrontal network connected at alpha frequencies. These findings represent a step further toward understanding the brain mechanisms underlying long‐lasting pain states in health and disease.

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Section: Discussionmentioning

confidence: 98%

Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans

Nickel

Dinh

et al. 2019

Human Brain Mapping

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“…Average delay between S1 and S2 in cats was 13 ms 30 , and mean latencies to activate area 17 from areas 18 and 19 were 6.1 and 10.4 ms respectively 31 . In humans, inter-hemispheric transmission between homologous S2 areas was reported to be of ~15 ms 32 , 33 , and direct electrical stimulation in epileptic patients estimated conduction times between insula and amygdala at 28 ± 3 ms 34 . Despite substantial variation of individual results around these averages 30 , 35 , published latency histograms show that 40–60% of cortico-cortical connections have latencies less than 10 ms 30 , 36 , 37 .…”

Section: Discussionmentioning

confidence: 99%

Convergence of sensory and limbic noxious input into the anterior insula and the emergence of pain from nociception

Bastuji

Frot

Perchet

et al. 2018

Sci Rep

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Two parallel di-synaptic routes convey nociceptive input to the telencephalon: the spino-thalamic system projecting principally to the posterior insula, and the spino-parabrachial pathway reaching the amygdalar nucleus. Interplay between the two systems underlies the sensory and emotional aspects of pain, and was explored here in humans with simultaneous recordings from the amygdala, posterior and anterior insulae. Onsets of thermo-nociceptive responses were virtually identical in the posterior insula and the amygdalar complex, but no significant functional connectivity was detected between them using coherence analysis. Anterior insular sectors responded with ~30 ms delay relative to both the posterior insula and the amygdala. While intra-insular functional correlation was significant during the whole analysis period, coherence between the anterior insula and the amygdala became significant after 700 ms of processing. Phase lags indicated information transfer initially directed from the amygdalar complex to the insula. Parallel but independent activation of sensory and limbic nociceptive networks appear to converge in the anterior insula in less than one second. While the anterior insula is often considered as providing input into the limbic system, our results underscore its reverse role, i.e., receiving and integrating very rapidly limbic with sensory input, to initiate a perceptual decision on the stimulus ‘painfulness’.

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“…Our findings show that the N1 wave is particularly involved in translating noxious stimuli into motor and autonomic responses. The N1 mostly originates from primary sensorimotor cortex 23 with additional contributions from operculo-insular and midcingulate/supplementary motor cortices 24 . It reflects an early processing stage, which occurs regardless of whether a noxious stimulus is consciously perceived 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a role of N2 and P2 waves in translating noxious stimuli into pain perception is in line with recent functional magnetic resonance imaging (fMRI) studies 15 , 17 . These studies have shown that BOLD responses from cingulate and operculo-insular cortices 5 , 24 , which are the main generators of the N2 and P2 waves are involved in translating noxious stimuli into pain perception. Most recent evidence has extended that view by revealing a particularly close link between the N2 and P2 waves, salience, and motor responses 28 , 29 .…”

Section: Discussionmentioning

confidence: 99%

Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli

et al. 2018

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Pain is a complex phenomenon involving perceptual, motor, and autonomic responses, but how the brain translates noxious stimuli into these different dimensions of pain is unclear. Here, we assessed perceptual, motor, and autonomic responses to brief noxious heat stimuli and recorded brain activity using electroencephalography (EEG) in humans. Multilevel mediation analysis reveals that each pain dimension is subserved by a distinct pattern of EEG responses and, conversely, that each EEG response differentially contributes to the different dimensions of pain. In particular, the translation of noxious stimuli into autonomic and motor responses involved the earliest N1 wave, whereas pain perception was mediated by later N2 and P2 waves. Gamma oscillations mediated motor responses rather than pain perception. These findings represent progress towards a mechanistic understanding of the brain processes translating noxious stimuli into pain and suggest that perceptual, motor, and autonomic dimensions of pain are partially independent rather than serial processes.

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Evidence‐based source modeling of nociceptive cortical responses: A direct comparison of scalp and intracranial activity in humans

Cited by 15 publications

References 69 publications

Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans

Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans

Convergence of sensory and limbic noxious input into the anterior insula and the emergence of pain from nociception

Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli

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