Evidence‐based routine use vs selective use of neoadjuvant therapy in practice: toward personalized management of advanced rectal cancer

Effectiveness of neoadjuvant concurrent chemoradiotherapy versus up-front proctectomy in clinical stage II-III rectal cancer: A population-based study

“…[4][5][6][7] However, whether this evidence-based recommendation should be followed routinely in clinical practice is still debated in the literature. 8 In addition, patient populations in the "real world" might be different when compared with those in clinical trials 9 ; to the best of our knowledge, reports in the literature on the population-based effectiveness of NCCRT are rare. 10,11 Therefore, the objective of our study is to investigate the nationwide population-based effectiveness of neoadjuvant concurrent chemoradiotherapy as compared with up-front proctectomy by analyzing the cancer registry and death registry of an Asian country (Taiwan).…”