Evidence-Based Review of Antibiofilm Agents for Wound Care

Weigelt, Maximillian A.; McNamara, Stephanie; Sanchez, Daniela P.; Hirt, Penelope A.; Kirsner, Robert S.

doi:10.1089/wound.2020.1193

Cited by 13 publications

(14 citation statements)

References 42 publications

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“…The mode of action and clinical significance of currently available antibiofilm products, including surfactants, dressings and others have been recently reviewed and are summarised below (Weigelt et al, 2021).…”

Section: Topical Therapies To Prevent Biofilm Reformationmentioning

confidence: 99%

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Review of the role of biofilms in equine wounds: Clinical indications and treatment strategies

Marchant,

Hendrickson,

Pezzanite

2023

Equine Veterinary Education

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SummaryRecognition of the role that biofilms play in the persistence of wounds and lack of response to therapy in horses is increasing. Prevention of biofilm development in the early stages of wound care involves three primary strategies: wound debridement and cleansing to reduce bacterial counts in the wound bed, appropriate use of advanced wound dressings and implementation of topical antimicrobial agents. Once formed, eradication of biofilms requires elimination to improve the wound environment for contraction and epithelialisation while not further harming the native cells integral to the healing process, which is achieved predominantly through repeated lavage and debridement combined with topical antimicrobial therapy. Pseudomonas, Enterococcus and Staphylococcus bacterial species have been most commonly identified in equine wounds with delayed healing. This review will establish why and how biofilms form, how to recognise clinical indications that biofilms have formed in equine wounds and review current diagnostic options and biofilm‐based wound care strategies to eradicate biofilms. Clinical scenarios for cases in which biofilms developed and were successfully treated will be presented. This review will advance practitioners' understanding of the presence and role of biofilms in equine wounds and provide an updated summary of recommended treatment strategies.

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Section: Topical Therapies To Prevent Biofilm Reformationmentioning

confidence: 99%

“…practice bound to roll gauze, sponges or other types of dressings (Hendrickson, 2019). Although its antibacterial properties are well-documented, further investigation of its use as an antibiofilm agent in higher powered clinical studies focusing on direct measurement of biofilm burden is warranted (Weigelt et al, 2021).…”

Section: Polyhexamethylene Biguanidementioning

confidence: 99%

Review of the role of biofilms in equine wounds: Clinical indications and treatment strategies

Marchant,

Hendrickson,

Pezzanite

2023

Equine Veterinary Education

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“…Wound management costs include supplies and dressings (15%‐20%), nursing time (30%‐35%), and hospitalisation (more than 50%) 5‐7 . Frequent dressing changes increase the cost of wound care.…”

Section: Introductionmentioning

confidence: 99%

“…Wound management costs include supplies and dressings (15%‐20%), nursing time (30%‐35%), and hospitalisation (more than 50%). 5 , 6 , 7 Frequent dressing changes increase the cost of wound care. Therefore, use of dressings that reduce the need for cleansing and debridement of wounds and are clinically more effective, are of a priority.…”

Section: Introductionmentioning

confidence: 99%

Emerging treatment strategies in wound care

Mirhaj

Labbaf

Tavakoli

et al. 2022

International Wound Journal

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Wound healing is a complex process in tissue regeneration through which the body responds to the dissipated cells as a result of any kind of severe injury. Diabetic and non-healing wounds are considered an unmet clinical need. Currently, different strategic approaches are widely used in the treatment of acute and chronic wounds which include, but are not limited to, tissue transplantation, cell therapy and wound dressings, and the use of an instrument. A large number of literatures have been published on this topic; however, the most effective clinical treatment remains a challenge. The wound dressing involves the use of a scaffold, usually using biomaterials for the delivery of medication, autologous stem cells, or growth factors from the blood. Antibacterial and anti-inflammatory drugs are also used to stop the infection as well as accelerate wound healing. With an increase in the ageing population leading to diabetes and associated cutaneous wounds, there is a great need to improve the current treatment strategies. This research critically reviews the current advancement in the therapeutic and clinical approaches for wound healing and tissue regeneration. The results of recent clinical trials suggest that the use of modern dressings and skin substitutes is the easiest, most accessible, and most cost-effective way to treat chronic wounds with advances in materials science such as graphene as 3D scaffold and biomolecules hold significant promise. The annual market value for successful wound treatment exceeds over $50 billion US dollars, and this will encourage industries as well as academics to investigate the application of emerging smart materials for modern dressings and skin substitutes for wound therapy.cells therapy, platelet therapy, skin tissue engineering, wound dressing, wound healing Key Messages• treatment of wound healing is currently considered an unmet clinical need • currently heavily under research are growth factors and cytokines released from platelets and leukocytes that have a significant effect on the cellular functions such as migration, differentiation, and proliferation, so they can regulate the wound healing process

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“…These disinfection properties have made super-oxidized water widely used in medicine for wound care and scar management [ 18 ]. Successful treatment outcomes, obtained in wound healing [ 20 ], suggest that electrochemically activated water provides biocompatibility and favorable cellular responses, making this solution a particularly attractive option for root canal treatment or the management of endodontic complications, where a high risk of irrigant extrusion into surrounding periodontal tissues exists. However, more evidence-based data on super-oxidized water cytotoxicity are needed to confirm its safe biological responses at the cellular level.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and Efficacy in Debris and Smear Layer Removal of HOCl-Based Irrigating Solution: An In Vitro Study

Bilvinaite

Zongolaviciute

Drukteinis

et al. 2022

JFB

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In the present study we evaluated the cytotoxicity of super-oxidized water on human gingival fibroblasts and its efficacy in debris and smear layer removal from root canal walls. Cultured gingival fibroblasts were exposed to super-oxidized water (Sterilox), which was diluted in Iscove’s modified Dulbecco’s medium (IMDM) at 30%, 40%, 50%, 60% and 70% concentrations. The control group was maintained in IMDM. The cell viability was evaluated by means of an MTT assay after incubation periods of 1 h, 2 h, 24 h and 48 h. Pathological cellular changes were also observed under fluorescence and phase contrast microscopes. The efficacy in debris and smear layer removal was evaluated in comparison to the conventional application of sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA). Forty maxillary premolars were randomly divided into two equal groups (n = 20) and shaped with ProTaper NEXT rotary instruments using Sterilox or NaOCl/EDTA for irrigation. Afterwards, roots were split longitudinally and examined under a scanning electron microscope. The results revealed that super-oxidized water and sterile distilled water have acceptable biological properties for endodontic applications at concentrations up to 50% (p > 0.05). Moreover, super-oxidized water is equally effective in debris and smear layer removal as compared to NaOCl/EDTA (p > 0.05).

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Evidence-Based Review of Antibiofilm Agents for Wound Care

Cited by 13 publications

References 42 publications

Review of the role of biofilms in equine wounds: Clinical indications and treatment strategies

Review of the role of biofilms in equine wounds: Clinical indications and treatment strategies

Emerging treatment strategies in wound care

Cytotoxicity and Efficacy in Debris and Smear Layer Removal of HOCl-Based Irrigating Solution: An In Vitro Study

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