Evidence-based precision nutrition improves clinical outcomes by analyzing human and microbial molecular data with artificial intelligence

Abstract

Background Current dietary recommendations are often generalized, conflicting, and highly subjective, depending on the source biases. This results in confusion, skepticism, and frustration in the general population. Methods We have developed an objective, integrated, automated, algorithmic approach to diet and supplement recommendations that is powered by artificial intelligence that analyzes individualized molecular data from the gut microbiome, the human host, and their interactions. This platform enables precise, personalized, and data-driven nutritional recommendations that consist of foods and supplements, based on the individual molecular data, to establish and maintain healthy homeostasis. Results We describe the application of our precision nutrition technology platform to populations with depression, anxiety, irritable bowel syndrome (IBS), and type 2 diabetes (T2D). In a blinded interventional study, we provided the study participants with precision nutritional recommendations and observed improvements in clinical outcomes by 36% in severe cases of depression, 40% in severe cases of anxiety, 38% in severe cases of IBS, and more than 30% in the T2D risk score that was validated against clinical measurements of HbA1c. Conclusion Our AI-driven precision nutrition program achieved statistically significant improvements in clinical outcomes of depression, anxiety, IBS, and type 2 diabetes. These data support the integration of precision food and supplements into the standard of care for these chronic conditions.

Altered gut microbial functional pathways in people with Irritable Bowel Syndrome enable precision health insights

“…Given these findings, we have employed the gut functional pathway scores as health insights within a large-scale health application. These pathway scores are used for nutritional recommendations described elsewhere [118]. Clinically, the microbiome is established as critically important for overall health and understanding the microbiome through evaluation of microbial functions (i.e., gene expression) could add substantial value to current diagnostic and treatment approaches.…”

Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

“…Within this product, these scores also facilitate a personal timeline of health insights across multiple time points, for individuals who re-test their oral health. Furthermore, the health insights delivered by these oral pathway scores can drive hygiene, dietary, lifestyle, and pharmaceutical recommendations [121] .…”

Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

“…The product also shows the longitudinal changes to the scores at multiple time points, for individuals who re-test their oral health. Furthermore, the health insights delivered by these oral pathway scores can drive hygiene, dietary, lifestyle, and pharmaceutical recommendations [98].…”