Evidence-based physical activity guidelines for cancer survivors: Current guidelines, knowledge gaps and future research directions

Buffart, Laurien M.; Galvão, Daniel A.; Brug, Johannes; Chinapaw, Mai J. M.; Newton, Robert U.

doi:10.1016/j.ctrv.2013.06.007

Cited by 212 publications

(191 citation statements)

References 120 publications

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“…The insulin-like growth factor (IGF) axis is a potentially significant mechanism that explains, at least in part, the inverse relationship between exercise and risk of cancer incidence (7)(8)(9). A full physiologic review of the IGF axis is beyond the scope of this review, those interested are referred to the work of Annunziata and colleagues (10).…”

Section: Physiologic Basis Of the Insulin-like Growth Factor Axis In mentioning

confidence: 99%

The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives

Devin

Bolam

Jenkins

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Exercise and physical activity have been shown to reduce the risk of many common cancers and strongly influence tumor biology. A cause-effect mechanism explaining this relationship is dependent on cellular pathways that can influence tumor growth and are exercise responsive. The insulin-like growth factor (IGF) axis is reported to promote the development and progression of carcinomas through cellular signaling in cancerous tissues. This review summarizes the physiologic basis of the role of the IGF axis in oncology and the influence of exercise on this process. We examined the effects of exercise prescription on the IGF axis in cancer survivors by evaluating the current scope of the literature.The current research demonstrates a remarkable heterogeneity and inconsistency in the responses of the IGF axis to exercise in breast, prostate, and colorectal cancer survivors. Finally, this review presents an in-depth exploration of the physiologic basis and mechanistic underpinnings of the seemingly disparate relationship between exercise and the IGF axis in oncology. Although there is currently insufficient evidence to categorize the effects of exercise prescription on the IGF axis in cancer survivors, the inconsistency of results suggests a multifaceted relationship, the complexities of which are considered in this review. Cancer Epidemiol Biomarkers Prev; 25(2);

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Section: Physiologic Basis Of the Insulin-like Growth Factor Axis In mentioning

confidence: 99%

The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives

Devin

Bolam

Jenkins

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…También se evidenciaron variaciones importantes en los protocolos de ejercicio en los estudios incluidos, lo cual refleja una heterogeneidad metodológi-ca a considerar y limita la recomendación de un programa de entrenamiento específico. Se sugiere adoptar las recomendaciones actuales para la prescripción de ejercicio físico en pacientes con cáncer 50 . No se publicó un protocolo previo de la presente revisión sistemática; dado que los investigadores no realizaron cambios considerables a la metodología propuesta inicialmente, y no se compromete la consistencia metodológica del estudio.…”

Section: Limitacionesunclassified

Efectividad del ejercicio físico en la fatiga de pacientes con cáncer durante el tratamiento activo: revisión sistemática y metaanálisis

et al. 2015

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“…A strong body of evidence supports exercise training as a therapy for cancer patients during and after anticancer treatment (7,8) because exercise training reverses some of the detriments that cancer causes in quality of life, fatigue, depression, muscular strength, and body composition (7)(8)(9)(10), without adverse side effects (11). Several of these signs and symptoms that occur commonly in cancer have been associated statistically and linked aetiologically with proinflammatory cytokines (12,13).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis

Meneses-Echávez

Correa-Bautista

González‐Jiménez

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n ¼ 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) ¼ À0.55 pg/mL; 95% confidence interval (CI), À1.02 to À0.09], TNFa (WMD ¼ À0.64 pg/mL; 95% CI, À1.21 to À0.06), IL8 (MD ¼ À0.49 pg/mL; 95% CI, À0.89 to À0.09), and IL2 (WMD ¼ 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD ¼ À0.15; 95% CI, À0.56 to 0.25) or IL10 (WMD ¼ 0.41; 95% CI, À0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population.

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Evidence-based physical activity guidelines for cancer survivors: Current guidelines, knowledge gaps and future research directions

Cited by 212 publications

References 120 publications

The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives

The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives

Efectividad del ejercicio físico en la fatiga de pacientes con cáncer durante el tratamiento activo: revisión sistemática y metaanálisis

The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis

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