Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations

Sun, Tao; Zhan, Junfei; Li, Fēi; Ji, Chenglong; Wu, Huifeng

doi:10.1016/j.scitotenv.2021.147076

Cited by 37 publications

(5 citation statements)

References 86 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a review of the literature concerning the effect of engineered nanomaterials on algae identified 46 hormetic-like dose responses [34] . Another detailed review of the published literature revealed an array of studies reporting hormetic responses of various terrestrial and aquatic creatures to micro-and nanoplastics [35] , which are also supported by the findings of recent meta-analyses of the effects of microplastics on aquatic organisms, with significant hormetic responses to environmentally realistic concentrations, not only for genotoxicity but also for reproduction endpoints [36,37] .…”

mentioning

confidence: 68%

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

Agathokleous¹,

Barceló²,

Fatta‐Kassinos³

et al. 2021

WECN

View full text Add to dashboard Cite

Contaminants of emerging concern are widespread in the world’s waters, raising concerns regarding their effects on living organisms. To evaluate the effects of and predict risks associated with such chemicals, dose-response studies are needed, while the nature of the dose-response relationship is critical for the outcomes of such evaluations. Here, we summarize the literature reporting hormetic responses of aquatic organisms to contaminants of emerging concern. Hormesis is a biphasic dose response encompassing stimulatory responses to low doses and inhibitory responses to high doses. We demonstrate that it occurs widely in numerous aquatic organisms exposed to a wide array of contaminants, including nano/microplastics, suggesting potential effects at doses/concentrations that are considerably lower than the traditional toxicological threshold, which cannot be identified or predicted unless hormesis is considered in the study design. To tackle the effects and associated risks of nano/microplastics and other contaminants on aquatic organisms, hormesis should therefore be taken into account early in the design of studies as well as in relevant risk assessments.

show abstract

mentioning

confidence: 68%

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

Agathokleous¹,

Barceló²,

Fatta‐Kassinos³

et al. 2021

WECN

View full text Add to dashboard Cite

show abstract

“…The exposure concentrations were 100 μg/L (L-MPs) and 1000 μg/L (H-MPs) for NIR-AIE-MPs, and 100 μg/L (L-NPs) and 1000 μg/L (H-NPs) for NIR-AIE-NPs, respectively. The exposure concentrations were chosen to correspond to low ambient concentrations and high ambient concentrations of microplastics in freshwater environment. , Each treatment contained 4 biological replicates. To minimize the drop in the nominal concentration of MNPs, the exposure solution was renewed every day, and the MNPs concentrations in the solution were monitored every day.…”

Section: Methodsmentioning

confidence: 99%

Near-Infrared-II In Vivo Visualization and Quantitative Tracking of Micro/Nanoplastics in Fish

Yang,

Tang,

Wang

2023

ACS Nano

View full text Add to dashboard Cite

As emerging contaminants, micro/nanoplastics (MNPs) are widely present in aquatic environments and are often ingested by aquatic organisms. However, the in vivo trafficking and fate of MNPs remain largely unknown. Here, we developed near-infrared (NIR) aggregated-induced emission (AIE) fluorophore-labeled microplastics (2 μm) and nanoplastics (100 nm) as models of MNPs. This model was based on the NIR-AIE technique with strong emission at the second near-infrared (NIR-IIII) window, which overcomes the interference of autofluorescence and observation artifacts in the detection of commercial fluorescent-labeled particles. Due to its deep tissue penetration and noninvasiveness, the dynamic process of accumulation and transport of MNPs in individuals can be tracked with NIR imaging. We then directly visualized and quantified the uptake and depuration processes of MPs and NPs in zebrafish. The results showed that the MPs and NPs were mainly accumulated in the fish gut, and the distribution was heterogeneous. MPs tended to accumulate more in the fore and mid areas of the gut compared with NPs. Besides, both MPs and NPs could accumulate in large quantities locally in the gut and might cause intestinal obstruction. MNPs accumulated slowly during the initial exposure followed by rapid and sustained accumulation in gut. Based on these kinetic accumulation and depuration, we developed a refined toxicokinetic (TK) model to describe the dynamic changes in the uptake and depuration of MNPs. Overall, this study proposed a MNP model based on the NIR-AIE technique, which provided a reliable tracer technology for the visualization, tracking and quantification of MNPs in vivo.

show abstract

“…Plastic particles can undermine the antioxidant defense mechanisms by increasing the production of ROS. Reactive oxygen species in turn cause DNA damage, which disrupts the genetic control of the proper DNA repair pathway [58,59]. Both the mitochondria and the nucleus can suffer DNA damage as a result of MP exposure [60].…”

Section: Causes Of the Negative Impact Of Mps On Organismsmentioning

confidence: 99%

Microplastics and Oxidative Stress—Current Problems and Prospects

Kadac-Czapska,

Ośko,

Knez

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community and the general public, as they threaten the environment. Microplastics contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, and apoptosis. They affect cells, tissues, organs, and overall health, potentially contributing to conditions like cancer and cardiovascular disease. They pose a significant danger due to their widespread occurrence in food. In recent years, information has emerged indicating that MPs can cause oxidative stress (OS), a known factor in accelerating the aging of organisms. This comprehensive evaluation exposed notable variability in the reported connection between MPs and OS. This work aims to provide a critical review of whether the harmfulness of plastic particles that constitute environmental contaminants may result from OS through a comprehensive analysis of recent research and existing scientific literature, as well as an assessment of the characteristics of MPs causing OS. Additionally, the article covers the analytical methodology used in this field. The conclusions of this review point to the necessity for further research into the effects of MPs on OS.

show abstract

Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations

Cited by 37 publications

References 86 publications

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

Near-Infrared-II In Vivo Visualization and Quantitative Tracking of Micro/Nanoplastics in Fish

Microplastics and Oxidative Stress—Current Problems and Prospects

Contact Info

Product

Resources

About