Evidence-based management of cutaneous scarring in dermatology part 2: atrophic acne scarring

Needle-Free Jet Injection of Poly-(Lactic Acid) for Atrophic Acne Scars: Literature Review and Report of Clinical Cases

“…Numerous approaches have been explored for managing atrophic acne scarring. Laser treatments (both fractional and non-fractional, encompassing ablative and non-ablative techniques), chemical peels (comprising glycolic acid, trichloroacetic acid, and Jessner's solution), microneedling, platelet-rich plasma as an adjunctive therapy, and dermal filler injections have been extensively investigated, backed by strong evidence-based support [4]. Among them, filler injections have gained widespread clinical acceptance and demonstrated promising outcomes for atrophic scar treatment [5].…”

“…Among them, filler injections have gained widespread clinical acceptance and demonstrated promising outcomes for atrophic scar treatment [5]. Various filler options, including collagen-based products, fat transfer, and silicon, are available, with hyaluronic acid (HA) being the most frequently used material for localized injections [4]. Fillers prove most effective for soft, rolling acne scars and can be directly injected beneath individual scars or applied broadly to regions with skin laxity or deep tissue atrophy [6].…”

“…Fillers prove most effective for soft, rolling acne scars and can be directly injected beneath individual scars or applied broadly to regions with skin laxity or deep tissue atrophy [6]. Combining fillers with other treatments can augment outcomes [4]. For instance, in a randomized control trial encompassing three groups of 20 patients each, the cohort receiving an HA filler with subcision displayed substantial improvements according to qualitative scar scale scores compared to subcision alone, exhibiting results akin to those achieved using a fractional laser plus subcision [7].…”

“…When injected into the subcutaneous layer, PLA generates gradual volume and promotes facial rejuvenation over an extended period [11]. PLA also corrects the contours of depressed scars by stimulating neocollagenesis [6], while the primary function of most dermal fillers in addressing atrophic scars is to enhance volume [4].…”

Poly‐d,l‐lactic acid‐enhanced atrophic scar treatment via transdermal microjet drug delivery in Asians

“… 1 Atrophic scars, the most prevalent type, present a significant therapeutic challenge due to their high prevalence and impact on patients' quality of life. 2 , 3 They develop due to irregular collagen production and degradation during the healing process, leading to an enzymatic breakdown of collagen fibres in the dermis. 4 Atrophic scars are commonly classified as ice pick, rolling, or boxcar scars.…”